The Rabbit anti-human Metalloreductase STEAP1 polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to STEAP1. This antibody recognizes Human antigen. The Rabbit anti-human Metalloreductase STEAP1 polyclonal Antibody has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis By similarity. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions