Rat Anti-Mouse CD71-FITC Antibody MBS673435 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD71-FITC Antibody
CompanyMyBioSource.com
Price $380.00Supplier Page View Company Product Page
Catalog NumberMBS673435
Quantity0.5 mg
ApplicationsFlow Cytometry, Immunoprecipitation
Conjugate/TagFITC
FormatFluorescein (FITC) Conjugate
ReactivityMouse
TargetCD71
IsotypeIgG2a kappa
CloneRI7217
HostRat
ImmunogenCD71/transferrin receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions)
CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells.^1, 4 It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation.^4 Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.^2
ClonalityMonoclonal