The NFKBID Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NFKB inhibitor delta, and NFKBID. This antibody recognizes Human, Mouse, and Rat antigen. The NFKBID Polyclonal Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes. IkappaBNS, the nuclear IkappaB-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens. IkappaBNS has been identified as a member of the IkappaB family of NF-kappaB inhibitors, which undergoes induction upon TCR signaling. IkappaBNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine