MyBioSource.com's MOUSE ANTI SOS1 Antibody is a Mouse monoclonal antibody. The MOUSE ANTI SOS1 Antibody was generated using GGF1, and SOS1 as the antigen. It reacts with Mouse. This antibody has been shown to work in applications such as: ELISA, Immunofluorescence, and Western Blot.
Description
Mouse anti Human SOS1 antibody, clone SOS-1 recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (Hart et al. 2002), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features (Hanna et al. 2009)