The PSEN1 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PRE1, Presenilin 1, PSEN1, X-PS-alpha, and X-PS-beta. This antibody recognizes Human, Mouse, and Rat antigen. The PSEN1 Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated gamma-secretase activity for amyloid-beta protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3)