Rat Anti-Mouse CD38-PE MBS673348 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD38-PE
CompanyMyBioSource.com
Price $250.00Supplier Page View Company Product Page
Catalog NumberMBS673348
Quantity0.1 mg
ApplicationsFlow Cytometry; Immunohistochemistry (Frozen Sections); Immunoprecipitation
Conjugate/TagR - phycoerythrin (R - PE)
FormatR - phycoerythrin (R - PE) Conjugate
ReactivityMouse
TargetCD38
IsotypeIgG2a kappa
Molecular Weight34,328 Da
Clone90
HostRat
Antibody TypeSecondary
ImmunogenCD38 (Mr 42-kDa), an immunoregulatory ectoenzyme
Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR).^1-3 It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice.^4 It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCR alpha beta ^+, CD4^-, CD8^-.5, 6 Murine CD38 is also expressed by all Mac-1^+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages.^4, 7 Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.^2,5, 8
NCBI Full Gene NameCD38 molecule
NCBI Gene AliasesADPRC 1, T10
ClonalityMonoclonal