The SOST Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to sclerostin, and SOST. This antibody recognizes Human, Mouse, and Rat antigen. The SOST Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease