The DMD Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DMD, and Dystrophin. This antibody recognizes Human, Mouse, and Rat antigen. The DMD Polyclonal Antibody has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
The dystrophin gene is the largest gene found in nature, measuring 2. 4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3, 500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level