The BD Horizon™ BV786 Mouse Anti-Human CD152 BNI3 50 Tests RUO Antibody from BD Biosciences is a Mouse Monoclonal antibody. This antibody recognizes Mouse antigen. The BD Horizon™ BV786 Mouse Anti-Human CD152 BNI3 50 Tests RUO Antibody has been shown to work in the following applications: Staining, and Flow Cytometry.
Description
The BNI3 monoclonal antibody specifically binds to the human cytolytic T lymphocyte-associated antigen (CTLA-4), also known as CD152. CTLA-4 is transiently expressed on activated CD28+ T cells and binds to CD80 and CD86 present on antigen presenting cells (APC) with high avidity. This interaction appears to deliver a negative regulatory signal to the T cell. Recent reports indicate that CTLA-4 is also expressed on B cells when cultured with activated T cells, suggesting a role for CTLA-4 in the regulation of B-cell response. Immobilized BNI3 antibody enhances T-cell proliferation induced by antibody-mediated crosslinking of CD3 and CD28. Recent studies have shown that CD152 can be expressed by regulatory T (Treg) cells. After cellular fixation and permeabilization, the BNI3 antibody can stain intracellular CD152 expressed in T cells including Treg cells. Clone BNI3 was studied in the VI Leukocyte Typing Workshop