MyBioSource.com's Epithelial Sodium Channel, alpha (ENAC Alpha) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot. The Epithelial Sodium Channel, alpha (ENAC Alpha) Antibody was generated using SCNN1A, and sodium channel epithelial 1 subunit alpha as the antigen and it reacts with Rat.
Description
Tissue acidosis (decrease in pH below the physiological level) that occurs in ischemia, tissue damage or inflammation is accompanied by pain. At the molecular level, H+-gated cation channels are activated by low pH in nociceptive neurons. H+-gated cation channels, members of the NaC/DEG superfamily of Na channels that include amiloride-sensitive epithelial Na+ channel proteins (alpha, beta, gamma and delta-ENaC subunits), are expressed in epithelia of the vertebrate kidney, colon, lung, tongue and brain. The ENaC subunits may form heterotrimeric active sodium channel. ENaCs are involved in sodium and water readsorption, and salty taste transduction. The superfamily of DEG/NaC proteins are characterized by intracellular N and C-termini, two TM domains, and a large extracellular loop.
ENaC alpha subunits have been cloned from various tissues and from several species (human 669aa, rat 698aa, mouse 699aa; ~80% inter-species homology). It controls the reabsorption of sodium in the kidney, colon, lung and sweat glands. ENaC alpha has also been implicated in taste perception. Defects in ENaC alpha are one of the cause of pseudohypoaldosteronism type I, a rare salt wasting disease characterized by dehydration, hyponatacemia, hyperkalemia and acidosis. Inactivation of ENaC alpha in transgenic mice causes an early death due to defective lung liquid clearance