MyBioSource.com's Rat Anti-Macrophage Colony Stimulating Factor Receptor Antibody is a Rat monoclonal antibody. The Rat Anti-Macrophage Colony Stimulating Factor Receptor Antibody was generated using CSF1R as the antigen. It reacts with Mouse. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
M-CSF R (macrophage colony stimulating factor receptor, c-fms) is a 165kD, 977aa type I membrane glycoprotein. It is a member of the type III subfamily of receptor tyrosine kinases that contain five extracellular immunoglobulin-like domains and a cytosolic split kinase domain. M-CSF receptor is expressed primarily on monocytes, macrophages, dendritic cells, and stem cells, and regulates lineage decisions and maturation of these cells. The mouse M-CSF R extracellular domain shares >99% aa identity with rat and 60-63% aa identity with human, dog, cat and cow M-CSF R. It can be released by TACE/ADAM17 cleavage