Rat Anti-Mouse CD22-UNLB MBS673256 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD22-UNLB
CompanyMyBioSource.com
Price $310.00Supplier Page View Company Product Page
Catalog NumberMBS673256
ApplicationsFlow Cytometry (FCM)
ClonalityMonoclonal
ReactivityMouse (Ms)
ImmunogenCD22 (Mr 150 kDa), a B lymphocyte adhesion molecule
CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM^+IgD^+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. ^1, 2 CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. ^2-4 Its intracellular domain is phosphorylated after antigen receptor crosslinking and is involved in negative regulation of B-cell activation. ^6-9
Antibody TypeSecondary
HostRat
Clone2D6 (also known as NIMR-6)
IsotypeIgG1 kappa
TargetCD22 (Lyb-8)
FormatPurified (UNLB) Antibody
Conjugate/TagUnconjugated
Quantity0.5 mg