Purified Anti-TYRP1 (MEL-5) 917801 from BioLegend

Product Specs
ItemPurified Anti-TYRP1 (MEL-5)
CompanyBioLegend
Price $392.00Supplier Page View Company Product Page
Catalog Number917801
Quantity1 mL
ApplicationsIHC-F - Quality tested
Conjugate/TagUnconjugated
FormatPhosphate-buffered solution with BSA + 0.09% NaN₃.

Previous lots of this product may have been formulated with 0.1% or 0.05% NaN₃ instead of 0.09% NaN₃
ReactivityHuman
IsotypeMouse IgG2a, kappa
CloneTa99
HostMouse
ImmunogenTa99 was developed using a SK-MEL-23 Melanoma cell line
NCBI Full Gene Nametyrosinase related protein 1
NCBI Gene AliasesCAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN
ClonalityMonoclonal
TargetTYRP1
Antibody TypePrimary
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Questions and Answers

Can this antibody be used for immunohistochemistry on frozen tissue sections?

Yes, the Purified Anti-TYRP1 (MEL-5) antibody has been shown to work in immunohistochemistry on frozen sections, as evidenced by its application in the study by Hahn et al. (2016), where it was utilized at a dilution of 1:100 for 16 hours at 4 °C.

What specific target does this antibody recognize, and what is its relevance in research?

This antibody targets tyrosinase-related protein 1 (TYRP1), which is significant in the study of melanoma and pigmentation disorders. Its role in the pathology of keloid scars has been highlighted in research, indicating its potential utility in understanding abnormal scarring processes.

Is there any evidence of this antibody being used in studies related to tumor immunology?

Yes, the Purified Anti-TYRP1 (MEL-5) antibody has been referenced in the context of tumor immunology, particularly in the study by Ruhland et al. (2020), where it was used to investigate the transfer of tumor antigens among dendritic cells, highlighting its relevance in cancer research.

What species does this antibody react with, and is it suitable for human studies?

The Purified Anti-TYRP1 (MEL-5) antibody is reactive with Homo sapiens (human), making it suitable for studies involving human tissues and cells, particularly in the context of melanoma research.

BioLegend

8999 BioLegend Way

San Diego, California 92121

United States

Phone: 1-877-246-5343 Toll-Free, USA & Canada
1-858-768-5800 International
Fax: 1-877-455-9587

Company Profile

Website: biolegend.com

(1) Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disordersJCI InsightAugust 24, 2026Monika B. Dolinska, Yuhong A. Wang, Nathan P. Coussens, Vijay K. Kalaskar, Zuhal Eraslan, Samuel J. Grondin, Joseph Bonica, Sarah Toay, Matthew D. Hall, Min Shen, et al.performed with the following antibodies and dilutions: anti-TYRP1antibody (BioLegend, San Diego, CA, USA, 917801, 1:200), following incubated with secondary antibody and counterstained with DAPI and then mounted with

(2) Human sensory neurons modulate melanocytes through secretion of RGMBCell reportsSeptember 20, 2022Chow SYA, Nakayama K, Osaki T, Sugiyama M, Yamada M, Takeuchi H, Ikeuchi Y.

(3) Visualizing Synaptic Transfer of Tumor Antigens among Dendritic CellsCancer cellJune 8, 2020Ruhland MK, Roberts EW, Cai E, Mujal AM, Marchuk K, Beppler C, Nam D, Serwas NK, Binnewies M, Krummel MF.RM4–5),eBioscience,47–0042-82 anti-mouse CD44 BV711 (clone IM7),Biolegend,103057 anti-mouse/human tyrosinase (TA99),Biolegend,917801 anti-mouse/human gp100 (clone HMB45),Biolegend,911504 anti-mouse biotin CD2 (clone RM2–5),Biolegend,100104 anti-mouse

(4) Human Melanocyte-Derived Spheroids: A Precise Test System for Drug Screening and a Multicellular Unit for Tissue EngineeringFrontiers in bioengineering and biotechnologyJanuary 1, 2020Zurina IM, Gorkun AA, Dzhussoeva EV, Kolokoltsova TD, Markov DD, Kosheleva NV, Morozov SG, Saburina IN.equivalent samples. Melanocytes in monolayer culture were incubated with primary antibodies against MEL5 (917801, BioLegend, 1:100). After preliminary preparations, sections and spheroids were incubated with primary

(5) Discovery of a Highly Selective MC1R Agonists Pentapeptide to Be Used as a Skin Pigmentation Enhancer and with Potential Anti-Aging PropertiesInternational journal of molecular sciencesDecember 5, 2019Jackson E, Heidl M, Imfeld D, Meeus L, Schuetz R, Campiche R.

(6) Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1Burns & traumaJanuary 1, 2016Hahn JM, McFarland KL, Combs KA, Supp DM.anti-tyrosinase-related protein 1 (TYRP1) mouse monoclonal antibody, clone Ta99 [42] (BioLegend, San Diego, CA, catalog #917801), used at 1:100 dilution (16 h, 4 °C); anti-laminin 5 mouse monoclonal antibody, clone P3H9-2 [43] (Abcam

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Purified Anti-TYRP1 (MEL-5) from BioLegend

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Purified Anti-TYRP1 (MEL-5) from BioLegend

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