Fig 1: Validation of Phip as a tumor suppressor.(a) Schematic diagram of the Phip gene indicating the sgRNA and shRNA targeted sites. The light blue shading represents untranslated regions whereas dark blue denotes coding exons. (b) Kaplan-Meier plot of tumor onset rates in mice receiving HSPCs infected with retroviruses expressing the indicated sgRNAs. Data from all cohorts receiving sgRosa26 are combined and used as reference in this plot. (c) Immunoblots comparing PHIP levels in sgPhip and sgRosa26 derived tumors. (d) Kaplan-Meier plot of tumor onset rates in mice receiving HSPCs transduced with retroviruses expressing shRNAs targeting Phip. Data from all cohorts receiving shRLuc.713 were pooled and used as reference. (e) Immunoblots comparing PHIP levels in sgRosa26- or shPhip.3809-derived tumors.