Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb 3556S from Cell Signaling Technology

Product Specs
ItemPhospho-RSK2 (Ser227) (D53A11) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number3556S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Mk
ModificationsRSK2 (Ser227) phosphate
HostRabbit
ClonalityMonoclonal
TargetRSK2 (Ser227) phosphate;RSK1 (Ser221) phosphate
NCBI Full Gene Nameribosomal protein S6 kinase A3, ribosomal protein S6 kinase A1
NCBI Gene AliasesISPK-1, RSK, HU-3, MAPKAPK1A, HU-1, XLID19, MRX19, p90-RSK2, p90Rsk, pp90RSK2, MAPKAPK1B, RSK1, RSK2, S6K-alpha3, MAPKAPK1, CLS
Research AreaMAP Kinase Signaling
IsotypeIgG
CloneD53A11
Molecular Weight90

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Propiconazole-Induced Testis Damage and MAPK-Mediated Apoptosis and Autophagy in Germ CellsCellsOctober 17, 2025Won-Young Lee, Ran Lee, Hyeon Woo Sim, Hyun-Jung Park,Cell signaling,#4668,(1:1000) JNK,Cell signaling,#9252,(1:1000) BAX,Cell signaling,#2772,(1:1000) phospho-p53,Cell signaling,#3556,(1:1000) p53,Cell signaling,#2524,(1:1000) List of antibodies used for immunostaining (Western blotting).

(2) Rsk2 inhibition induces an aneuploid post-mitotic arrest of cell cycle progression in osteosarcoma cellsCell Death DiscovJuly 10, 2025Armelle Carreau, Christina Baldauf, Lena Warlich, Magdalena Weingartner, Laura Brylka, Michael Amling, Thorsten Schinke, Julia Lutherantibodies anti-β-actin (#5732 1:1000), Rsk2 (#5528 1:1000) or phosphorylated Rsk2 on serine 227 (#3556 1:1000 in TBS-T 5% BSA), all obtained from Cell Signaling Technology (Massachusetts, USA). HRP-conjugated

(3) Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progressionJCI InsightJuly 8, 2025Yang Liu, Lizhi Pang, Fatima Khan, Junyan Wu, Fei Zhou, Craig Horbinski, Shideng Bao, Jennifer S. Yu, Justin D. Lathia, Peiwen Chen(Proteintech, 66926-1-Ig), CD133 (Biosis, BS-4770R), SOX2 (Abcam, ab97959), P-RSK2 (Cell Signaling Technology, 3556S), RSK2 (Cell Signaling Technology, 9355S), P-PYK2 (Cell Signaling Technology, 3291S), PYK2 (Cell Signaling Technology

(4) AKT-independent signaling in PIK3CA-mutant thyroid cancer mediates resistance to dual SRC and MEK1/2 inhibitionMedical OncologySeptember 15, 2023Madison M. Rose, Kelsey W. Nassar, Vibha Sharma, Rebecca E. SchweppeSubstrate RXXS*/T* (9614), pmTOR S2448 (2971), mTOR (4517), pS6 240/244 (5364), S6 (2317), pRSK2 S227 (3556), pNDRG1 T346 (5482), Vinculin (13901) and from CalbioChem: Alpha Tubulin (CP06). Cell Growth Assays CellTiter-Glo 2.0 Assay

(5) Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinasesLife Science AllianceMay 1, 2023Marlene Uglebjerg Fruergaard, Christine Juul Fælled Nielsen, Cecilia Rosada Kjeldsen, Lars Iversen, Jacob Lauwring Andersen, Poul Nissenmembranes (Bio-Rad) and tested with antibodies: anti-phospho-p90RSK (S380) #9341, anti-phospho-RSK2 (S227) #3556, anti-RSK1/RSK2/RSK3 #9355, anti-β-actin #8457, and HRP anti-rabbit #7074, (all from Cell Signaling).

(6) Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infectionGut microbesJanuary 1, 2023Yuan H, Zhou L, Chen Y, You J, Hu H, Li Y, Huang R, Wu S.Cell Signaling Technology), rabbit anti caspase-8 (AC056; Beyotime), Phospho-RSK2 (Ser227) Rabbit mAb (#3556S; Cell Signaling Technology), PDK1 (D37A7) Rabbit mAb (#5662S; Cell Signaling Technology), Caspase-3 (D3R6Y) Rabbit mAb

(7) CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathwayJournal of experimental & clinical cancer research : CRAugust 13, 2022Zhang X, Guo Y, Xiao T, Li J, Guo A, Lei L, Jin C, Long Q, Su J, Yin M, et al.antibody (1:1000, ab666, Abcam, MA, USA), rabbit monoclonal anti-phospho-RSK2 (Ser227) antibody (1:1000, 3556 s, Cell Signaling Technology, MA, USA), rabbit monoclonal anti-RSK2 antibody (1:1000, 5528 s, Cell Signaling Technology

(8) PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2International journal of molecular sciencesAugust 8, 2022Chen Q, Jin J, Guo W, Tang Z, Luo Y, Ying Y, Lin H, Luo Z.(Thr638/641),9375,"Cell Signaling Tech. (Danvers, MA, USA)" p-S6 (Ser235/236),4858,Cell Signaling Tech. p-RSK2 (Ser227),3556,Cell Signaling Tech. p-Akt (Thr308),13038s,Cell Signaling Tech. p-Akt (Ser473),4060s,Cell Signaling

(9) Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not AktLife Science AllianceJune 1, 2022Brittany L Dunkerly-Eyring, Shi Pan, Miguel Pinilla-Vera, Desirae McKoy, Sumita Mishra, Maria I Grajeda Martinez, Christian U Oeing, Mark J Ranek, David A Kass#9101 and total p44/42 MAPK (ERK1/2) #9102, pRSK (T359/S363) #9344 and total RSK #9355, pRSK2 S227 #3556S and total RSK2 (#5528S) (all from Cell Signaling Technology, and used a 1:1,000 dilution), and p-TSC2

(10) Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptakeCell reportsMarch 15, 2022Hu SH, He XD, Nie J, Hou JL, Wu J, Liu XY, Wei Y, Tang HR, Sun WX, Zhou SX, et al.,Cell Signaling Technology,Cat# 3063; RRID: AB_2225186 phospho-RSK2(S227),Cell Signaling Technology,Cat# 3556; RRID: AB_2181465 RSK2,Cell Signaling Technology,Cat# 5528; RRID: AB_10860075 phospho-AS160(T642),Cell Signaling Technology

(11) Akt regulates RSK2 to alter phosphorylation level of H2A.X in breast cancerOncology LettersJanuary 6, 2021Zhi-Feng Guo, Fan-Long Kong(t-GSK3β, cat. no. 9331, dilution 1:1,000), Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb (p-RSK2, cat. no. 3556; dilution 1:1,000), RSK2 (D21B2) XP® Rabbit mAb (cat. no. 5528; dilution 1:1,000) were purchased from

(12) Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathwayScience signalingMay 5, 2020Duron DI, Lei W, Barker NK, Stine C, Mishra S, Blagg BSJ, Langlais PR, Streicher JM.(1:1000; Cell Signaling Technology, 8408S, lot 5, rabbit), pRSK2 (1:1000; Cell Signaling Technology, 3556S, lot 4, rabbit), tRSK2 (1:1000; Cell Signaling Technology, 5528S, lot 1, rabbit), MAP2 (1:500; Invitrogen,

(13) Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 PathwayCellsMay 29, 2019Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten EM.anti-FGFR4 (#8562), rabbit anti-phospho-PLCγ (Tyr783) (#14008), and rabbit anti-phospho-RSK2 (Ser 227) (#3556) from Cell Signaling Technology (Leiden, The Netherlands) and mouse anti-γ-tubulin (T6557) from Sigma-Aldrich

(14) Aminoglycosides rapidly inhibit NAD(P)H metabolism increasing reactive oxygen species and cochlear cell demiseJournal of Biomedical OpticsNovember 8, 2018Danielle E. Desa, Michael G. Nichols, Heather Jensen Smithuptake underlies ROS generation during aminoglycoside-induced hair cell death,” J. Clin. Invest. 126(9), 3556–3566 (2016). 15. P. D. Ray, B.-W. Huang, and Y. Tsuji, “Reactive oxygen species (ROS) homeostasis and

(15) Aflatoxin B1 Promotes Influenza Replication and Increases Virus Related Lung Damage via Activation of TLR4 SignalingFrontiers in ImmunologyOctober 4, 2018Yuhang Sun, Jiarui Su, Zixuan Liu, Dandan Liu, Fang Gan, Xingxiang Chen, Kehe Huang

(16) Astragaloside IV ameliorates early diabetic nephropathy by inhibition of MEK1/2-ERK1/2-RSK2 signaling in streptozotocin-induced diabetic miceThe Journal of International Medical ResearchJune 13, 2018Gaofeng Song, Pengxun Han, Huili Sun, Mumin Shao, Xuewen Yu, Wenjing Wang, Dongtao Wang, Wuyong Yi, Na Ge, Shunmin Li, Tiegang Yi(#4370, Cell Signaling Technology® (CST), Danvers, MA, USA), ERK1/2 (#4695, CST), p-RSK2 (Ser227) (#3556, CST), RSK2 (#5528, CST), p-MEK1/2 (ser217/221) (#9154, CST), MEK1/2(47E6) (#9126, CST). β-actin (Sigma-Aldrich)

(17) Anti-Inflammatory Effect of a Polyphenol-Enriched Fraction from Acalypha wilkesiana on Lipopolysaccharide-Stimulated RAW 264.7 Macrophages and Acetaminophen-Induced Liver Injury in MiceOxidative medicine and cellular longevityJanuary 1, 2018Wu H, Pang H, Chen Y, Huang L, Liu H, Zheng Y, Sun C, Zhang G, Wang G.

(18) Toll-Like Receptor-4/p38 MAPK Signaling in the Dorsal Horn Contributes to P2X4 Receptor Activation and BDNF Over-secretion In Cancer Induced Bone PainNeuroscience ResearchJune 22, 2017Xiao-wen Meng, Jian-ling Gao, Jian-Ling Zuo, Li-Na Wang, Si-lan Liu, Xiao-Hong Jin, Ming Yao, Michael Namaka

(19) Toll-Like Receptor 4 in Paraventricular Nucleus Mediates Visceral Hypersensitivity Induced by Maternal SeparationFrontiers in PharmacologyMay 29, 2017Hui-Li Tang, Gongliang Zhang, Ning-Ning Ji, Lei Du, Bin-Bin Chen, Rong Hua, Yong-Mei Zhang

(20) IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain InjuryFrontiers in neurologyJanuary 1, 2017Gao W, Li F, Zhou Z, Xu X, Wu Y, Zhou S, Yin D, Sun D, Xiong J, Jiang R, et al.

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Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb

Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb from Cell Signaling Technology

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