Smad2/3 (C-8) Antibody sc-133098 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSmad2/3 (C-8) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-133098
Quantity200 µg/ml
Reactivitymouse, rat, human
Conjugate/TagUnconjugated
FormatPurified
ApplicationsWB, IP, IF, IHC(P), ELISA
Antibody TypePrimary Antibodies
CloneC-8
Hostmouse
TargetSmad3
IsotypeIgG2a
NCBI Gene AliasesJV18, JV18-1, 7120426M23Rik, MADR2, Smad-2, HsT17436, hSMAD3, mad3, mMad2, hSMAD2, Madr2, MADH3, MADH2, hMAD-3, hMAD-2, HSPC193, JV15-2, Madh3, Madh2, LDS6, LDS3, CHTD8, LDS1C
ClonalityMonoclonal
NCBI Full Gene NameSMAD family member 3, SMAD family member 2

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) YAP1 and QSER1 are key modulators of embryonic signaling pathways in the mammalian epiblastEMBO ReportsMarch 26, 2026Elizabeth Abraham, Thomas Roule, Aidan Douglas, Emily Megill, Olivia M Pericak, Jordan E Howe, Carmen Choya-Foces, Joanne F Garbincius, Henry M Cohen, Paula Roig-Flórez, et al.anti-Gapdh,Protein Tech,60004-1 Mouse anti-Histone H3,Abcam,ab1791 Mouse anti-Smad2/3,Santa Cruz,sc-133098 Mouse anti-Kdr/Flk1,R&D Systems,FAB357P Rabbit anti-Laminb1,Abcam,ab16048 Mouse anti-Yap1,Santa Cruz,sc-101199 Mouse

(2) TGF-β1 Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through Smad4-Dependent MechanismCurrent Issues in Molecular BiologyMarch 25, 2026Pan Wu, Yiling Wei, Xiang Chen, Qingmei Mo, Ming Zhuonumber: JM10-59, ET1703-22, 1:500, Hangzhou Huaan Biotechnology Co., Ltd., Hangzhou, China), Smad3 (sc-133098), Smad4 (sc-7966), which were both from Santa Cruz, and, after washing the slides three times with PBS

(3) Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancerSci AdvMarch 20, 2026Marjaana Parikainen, Ujjwal Suwal, Pekka Rappu, Jyrki Heino, Cecilia M. Sahlgren(Cell Signaling Technology, cat. no. 8828, RRID: AB_2631089), 1:1000 Smad2/3 (Santa Cruz Biotechnology, cat. no. sc-133098, RRID: AB_2193048), 1:1000 αSMA (Cell Signaling Technology, cat. no. 19245, RRID: AB_2734735), 1:2500

(4) Basement membrane remodeling with fibroblast activation and cystatin C aggregation in cerebral vessels of hereditary cystatin C amyloid angiopathyActa Neuropathologica CommunicationsJanuary 27, 2026Asbjorg Osk Snorradottir, Hjalti Karl Hafsteinsson, Klara Hansdottir, Saevar Ingthorsson, Sigurdur Runar Gudmundsson, Angelos Skodras, Helgi J. Isaksson, Hakon Hakonarsonmin WNT-1,"Santa Cruz, sc-514531","Mouse, monoclonal",pH 6,1:30,Overnight at 4 °C SMAD2/3,"Santa Cruz, sc-133098","Mouse, monoclonal",pH 6,1:,Overnight at 4 °C pSMAD2/3,"Invitrogen, PA5-110155",Mouse monoclonal,pH

(5) BMP and NODAL paracrine signalling regulate the totipotent-like cell state in embryonic stem cellsFrontiers in Cell and Developmental BiologyJanuary 23, 2026Sanidhya Jagdish, Loick Joumier, Sabin Dhakal, Gilberto Duran-Bishop, Mohammed Usama, Mohan Malleshaiahanti-phospsho-SMAD2 (S465/467)/SMAD3 (S423/425) (Cell Signaling, #8828S; 1:1,000 dilution), anti-SMAD2/3 (Santa Cruz, sc-133098; 1:1,000 dilution), GAPDH (Santa Cruz, sc-32233; 1:5,000 dilution). After washing, membranes were incubated

(6) SERPINB5-TGF-β signalling modulates desmoplakin membrane localization and ameliorates pemphigus vulgaris skin blisteringJCI InsightNovember 24, 2025Maitreyi Rathod, Mariam Petrosyan, Aude Zimmermann, Maike Märker, Tobias Gosau, Henriette Franz, Tomás Cunha, Dario Didona, Michael Hertl, Enno Schmidt, et al.Santa Cruz Biotechnology), rabbit pSMAD2/3 (AP0548 Lubioscience), rabbit pSMAD1/3/5 (ab95455 Abcam), mouse SMAD2/3 (sc-133098 Santa Cruz Biotechnology), and pPG S665 (from Jens Waschke, Ludwig-Maximilians-University [LMU], Munich,

(7) Ligand-specific regulation of a binary enhancer code dictating cellular senescenceProceedings of the National Academy of Sciences of the United States of AmericaJune 17, 2025Suter T, Friedman MJ, Tazearslan C, Merkurjev D, Ohgi K, Meluzzi D, Rosenfeld MG, Suh Y.applications. Antibodies. The following antibodies were used in this publication: SMAD2/3, Santa Cruz sc-6032 (N19) and sc-133098 (C-8) in an equimolar cocktail; NFI, Santa Cruz sc-5567 (H-300); p65, Santa Cruz sc-372 (C-20); H3K4me2,

(8) N-acetylcysteine and raloxifene boost photodynamic therapy against cutaneous squamous cell carcinoma by decreasing TGFβ1 secreted by cancer-associated fibroblastsInt J Biol SciApril 28, 2025María Gallego-Rentero, Luisa María Botella, Marta Mascaraque, Jimena Nicolás-Morala, Virginia Albiñana, Edgar Abarca-Lachen, Yolanda Gilaberte, Salvador González, Ángeles Juarranz, Elisa Carrascoat room temperature. Coverslips were subsequently incubated with primary antibodies against SMAD2/3 (sc-133098, Lot. L0820, Santa Cruz Biotechnologies, DA, USA) or endoglin (kindly provided by Dr. Botella and obtained

(9) Uniform and controllable surface nano-structure on polyetheretherketone implants can regulate mechanical property to enhance soft tissue integration through Piezo1/TGF-β1 signaling axisMater Today BioMarch 8, 2025Sida Liu, Yixuan Chen, Gandong Zhou, Changning Sun, Minghai Ma, Rou Huang, Xing Li, Xiao Liang, Changquan Shi, Weiwei Wu, et al.(21898-1-AP), α-SMA (14395-1-AP), and YAP1 (13584-1-AP) were acquired from Proteintech Group, Inc. Smad2/3 (sc-133098) was acquired from Santa Cruz Biotechnology, Inc. IL-6 (GB11117) and TNF-α (GB115702) was acquired from

(10) Overlapping and Distinct Physical and Biological Phenotypes in Pure Frailty and Obese FrailtyBioscience ReportsNovember 27, 2024Fujue Ji, Ji Hyun Park, Hyeonseung Rheem, Jong-Hee Kim,Cell signaling,#9272,1:500 p-Smad2Ser465/467/3Ser423/425,Rabbit lgG,Cell signaling,#8828,1:1000 Smad2/3,Mouse lgG,Santa Cruz,sc-133098,1:1000 p-FoxO3aSer253,Rabbit lgG,Cell signaling,#13129,1:500 FoxO3a,Rabbit lgG,Cell signaling,#12829,1:500 Beclin-1,Rabbit

(11) IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathwaysCell Communication and SignalingNovember 12, 2024Yesuf Siraj, Domenico Aprile, Nicola Alessio, Gianfranco Peluso, Giovanni Di Bernardo, Umberto GalderisiIGF1R (sc271606), IGF2R (sc-245462), Insulin (sc-8033), INSR (sc-57344), P21CIP1 (sc-6246), SMAD2/3 (sc-133098) were obtained from from Santa Cruz Biotechnology (Dallas, TX, USA); ACVR1 (EAB-14737), ACVR1B (EAB-60969),

(12) Overlapping and Distinct Physical and Biological Phenotypes in Pure Frailty and Obese FrailtyBiosci RepNovember 6, 2024Fujue Ji, Ji Hyun Park, Hyeonseung Rheem, Jong-Hee Kim,Cell signaling,#9272,1:500 p-Smad2Ser465/467/3Ser423/425,Rabbit lgG,Cell signaling,#8828,1:1000 Smad2/3,Mouse lgG,Santa Cruz,sc-133098,1:1000 p-FoxO3aSer253,Rabbit lgG,Cell signaling,#13129,1:500 FoxO3a,Rabbit lgG,Cell signaling,#12829,1:500 Beclin-1,Rabbit

(13) Protective effect of Huashi Baidu formula against AKI and active ingredients that target SphK1 and PAI-1Chinese MedicineNovember 1, 2024Yute Zhong, Xia Du, Ping Wang, Weijie Li, Cong Xia, Dan Wu, Hong Jiang, Haiyu Xu, Luqi Huang(bs-0982R, Bioss, China), IκB-α (10268–1-AP, Proteintech, China), p-IκB-α (2859, CST, USA), SMAD2/3 (sc-133098, Santa Cruz, USA), p-SMAD2 (18338, Santa Cruz, USA), PAI-1 (66261–1-Ig, Proteintech, China), and transforming

(14) Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinomaJournal of Biological ChemistryApril 1, 2024Cheng Zhang, Wenjing Wei, Shuo Tu, Bo Liang, Chun Li, Yining Li, Weicheng Luo, Yiqing Wu, Xiaohui Dai, Yi Wang, et al.Cell Signaling Technology. Antibodies recognizing GAPDH (sc-47724), β-actin (sc-8432), and Smad2/3 (sc-133098) were purchased from Santa Cruz Biotechnology. Chromatin immunoprecipitation Cancer cells were firstly

(15) Radiation-induced effects on TGF-β and PDGF receptor signaling in cancer-associated fibroblastsCancer Rep (Hoboken)March 15, 2024Nannan Yang, Turid Hellevik, Rodrigo Berzaghi, Inigo Martinez-Zubiaurre,Novus Biologicals,NB100‐56656,1:1000 Human pSMAD1/5/9,Cell Signaling Technology,13820,1:1000 Human SMAD2/3 (C‐8),Santa Cruz,sc‐133098,1:200 Human pSMAD2/3,Cell Signaling Technology,8828s,1:1000 Human pPDGFR‐β,Cell Signaling Technology,3161,1:500 Human

(16) Cholesterol modulates type I/II TGF-β receptor complexes and alters the balance between Smad and Akt signaling in hepatocytesCommunications BiologyJanuary 2, 2024Roohi Chaudhary, Laureen S. Goodman, Sai Wang, Anastasia Asimakopoulos, Ralf Weiskirchen, Steven Dooley, Marcelo Ehrlich, Yoav I. Henis(diphosphorylated Erk1/2) antibody (cat. #M8159) was from Sigma-Aldrich. Murine IgG to tSmad2/3 (cat. #sc-133098) was from Santa Cruz Biotechnology (Santa Cruz, CA), and mouse anti-β-actin (cat. #08691001) from MP

(17) Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysmInternational journal of biological sciencesJanuary 1, 2024Hong YK, Cheng TL, Hsu CK, Lee FT, Chang BI, Wang KC, Chang LY, Wu HL, Lai CH.with primary antibodies against TEM1 (18160-1-AP; Proteintech), SM22α (GTX113561; GeneTex), SMAD2 (sc-133098; Santa Cruz Biotechnology) and p-SMAD2 (8828S; Cell Signaling, Danvers, MA) overnight at 4°C and washed

(18) Deep learning untangles the resistance mechanism of p53 reactivator in lung cancer cellsiScienceDecember 15, 2023Soo Min Lee, Younghyun Han, Kwang-Hyun Chosamples on ice. For immunoblotting, anti-THBS1 (sc-59887), anti-TGFβ1 (sc-130348), and anti-SMAD2/3 (sc-133098) were obtained from Santa Cruz Biotechnology Inc., and anti-phospho-SMAD2/3 (#8828) was purchased from

(19) Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbersCommunications biologyOctober 18, 2023Neely AE, Zhang Y, Blumensaadt LA, Mao H, Brenner B, Sun C, Zhang HF, Bao X.IKKα (B-8) (Santa Cruz, sc-7606, 1:50), PDI (Cell Signaling, #3501, 1:100), and SMAD2/3 (Santa Cruz, sc-133098, 1:50). Secondary antibodies (Life Technologies, A11304 and A11005) were diluted at 1:400 for incubation

(20) Pattern detection in the TGFβ cascade controls the induction of long-term synaptic plasticityProceedings of the National Academy of SciencesOctober 3, 2023Paige Miranda, Anastasios A. Mirisis, Nikolay V. Kukushkin, Thomas J. Carewwith primary antibodies and secondary antibodies: anti-Smad2/3 (1:1,000; Santa Cruz Biotechnology, sc-133098) and anti-mouse IgG IRDye 680L (1:10,000; LICOR Biosciences, #926-68 020). Protein levels and band weights

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Smad2/3 (C-8) Antibody

Smad2/3 (C-8) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Smad2/3 (C-8) Antibody from Santa Cruz Biotechnology, Inc.

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