PRRX1 Antibody NBP1-06067 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemPRRX1 Antibody
CompanyNovus Biologicals, a Bio-Techne Brand
Price $419.00Supplier Page View Company Product Page
Catalog NumberNBP1-06067
ImmunogenPeptide with sequence C-GSDTPQQDNDQ corresponding to internal region according to NP_008833.1, NP_073207.1
NCBI Gene AliasesPMX1, AGOTC, PHOX1, PRX1, PRX-1
Concentration0.5 mg/ml
ReactivityHuman,Mouse
Quantity0.1 mg
FormatTris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
ApplicationsIF/IHC,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Peptide ELISA,Immunocytochemistry/ Immunofluorescence
Conjugate/TagUnconjugated
HostGoat
TargetPRRX1
NCBI Full Gene Namepaired related homeobox 1
ClonalityPolyclonal
PurityImmunogen affinity purified
IsotypeIgG
Antibody TypePrimary Antibodies
Research AreaGrowth and Development, Neuronal Cell Markers
StorageStore at -20C. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: This antibody is expected to recognise both reported isoforms (NP_008833.1; NP_073207.1).

Sizes Available: 0.1 mg

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Questions and Answers

Can this antibody be used for studying PRRX1 in cancer research?

Yes, the PRRX1 antibody has been utilized in cancer research, particularly in studies related to hepatocellular carcinoma. For instance, it has been shown that PRRX1 expression levels correlate with the p53 signaling pathway, influencing cell migration and apoptosis in cancer cells, which may have implications for understanding tumor progression and patient prognosis ().

Is this antibody effective for immunohistochemistry applications?

The PRRX1 antibody has been successfully used in immunohistochemistry, as demonstrated in studies where it was applied to tissue sections to analyze PRRX1 expression in various contexts, including pancreatic regeneration and glioma-initiating cells (, ).

What role does PRRX1 play in developmental biology, particularly in tooth development?

PRRX1 has been implicated in the regulation of epithelial-mesenchymal interactions during tooth development. It enhances the expression of microRNA-875, which is crucial for mesenchymal condensation and cell migration in dental mesenchyme, indicating its significant role in organ development ().

Are there specific isoforms of PRRX1 that this antibody recognizes?

Yes, the PRRX1 antibody is expected to recognize both reported isoforms of PRRX1, which are involved in various biological processes, including migration and invasion in pancreatic cancer cells ().

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Nociceptive sensory neuron-derived NGF orchestrates a fibrotic mesenchymal stromal cell neurogenic niche to drive tendon pathological fibrosisNature communicationsDecember 10, 2025Li Y, Pang S, Zhang X, Lu M, Zhao J, Wu R, Hu J, Jiang J, Chen H, Ling Z, et al.(Aves Labs, NES, 1:200); TrkA (BIOSS, bs-0193R, 1:200); and Hif1α (NOVUS, H1alpha67, 1:300); Prrx1(NOVUS, NBP1-06067, 1:200); Collagen 1(Abcam, 138492, 1:200 for IF, 1:500 for WB); Collagen 3(Abcam, 184993, 1:200 for

(2) Identification of human cranio-maxillofacial skeletal stem cells for mandibular developmentSci AdvJanuary 3, 2025Zhuo Wang, Kun Wang, Yejia Yu, Jing Fu, Siyuan Zhang, Maojiao Li, Jian Yang, Xuanhao Zhang, Xiaodong Liu, Fengqiong Lv, et al.(Santa Cruz Biotechnology, sc-515877; 1:100), Dlx5 (Santa Cruz Biotechnology, sc-398150; 1:100), Prrx1 (Novus, NBP1-06067; 1:100), RUNX2 (Abcam, ab76956; 1:200), IFITM5 (Adcepta, AP11058c; 1:200), COL1A2 (Zen, 380760; 1:200),

(3) Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell PlasticityMolecular neurobiologyMarch 1, 2024Jung M, Jung JS, Pfeifer J, Hartmann C, Ehrhardt T, Abid CL, Kintzel J, Puls A, Navarrete Santos A, Hollemann T, et al.,Santa Cruz,Sc-5279 Mouse IgG anti-humanPAX6,IF: 1:100,Santa Cruz,Sc-53108 Goat IgG anti-humanPRRX1,IF: 1:100,Bio-Techne,NBP1-06067 Rabbit IgG anti-humanp21m (CDKN1A),WB: 1:1000; IF: 1:800,Cell Signaling Technology,2947 Mouse IgG

(4) 821 The Prrx1 Homeodomain Transcription Factor Plays a Central Role in Pancreatic Regeneration and CarcinogenesisGastroenterologyMay 1, 2013Maximilian Reichert et al.of Iowa), anti-PDX1 (dilution 1:1000; A-17, Santa Cruz Biotechnology), anti-PRRX1 (dilution 1:250; NBP1-06067, Novus Biologicals), anti-PRRX1 (dilution 1:20; HPA051084, Sigma), anti-GFP (dilution 1:250; ab13970,

(5) Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biologyCancer researchJanuary 15, 2007Yun-Jeong Kim, Ji-Yeon Ahn, Ping Liang, Clement Ip, Yuesheng Zhang, Young-Mee Park

(6) Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinomaOncology reportsJanuary 1, 0001"Fan M, Shen J, Liu H, Wen Z, Yang J, Yang P, Liu K, Chang Y, Duan J, Lu K."antigen retrievals. Slides were incubated in monoclonal antibodies against goat polyclonal anti-PRRX1 (NBP1-06067, 1:50 dilutions; Novus Biologicals LLC, Littleton, CO, USA), rabbit monoclonal anti-p53 (ab179477, 1:100

(7) microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth developmentScientific reportsJanuary 1, 0001"Funada K, Yoshizaki K, MIyazaki K, Han X, Yuta T, Tian T, Mizuta K, Fu Y, Iwamoto T, Yamada A, et al."visualized by DAPI. Immunostaining of molars was performed using the primary antibody against PRRX1 (NBP1-06067, 1:500, Novus Biologicals). Images were captured using a C2 confocal microscope (Nikon) and analyzed

(8) PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3AMolecular oncologyJanuary 1, 0001"Tanabe R, Miyazono K, Todo T, Saito N, Iwata C, Komuro A, Sakai S, Raja E, Koinuma D, Morikawa M, et al."ng·mL−1. The antibodies used were as follows: anti‐PRRX1 (ab67631, Abcam, Cambridge, UK), anti‐PRRX1 (NBP1‐06067, Novus Biological, Centennial, CO, USA), anti‐PRRX1 C‐terminal (ab174201, Abcam), anti‐α‐tubulin (T6199,

(9) The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesisGenes & developmentJanuary 1, 0001"Reichert M, Takano S, von Burstin J, Kim SB, Lee JS, Ihida-Stansbury K, Hahn C, Heeg S, Schneider G, Rhim AD, et al."of Iowa), anti-PDX1 (dilution 1:1000; A-17, Santa Cruz Biotechnology), anti-PRRX1 (dilution 1:250; NBP1-06067, Novus Biologicals), anti-PRRX1 (dilution 1:20; HPA051084, Sigma), anti-GFP (dilution 1:250; ab13970,

(10) A Na⁺/K⁺ ATPase Pump Regulates Chondrocyte Differentiation and Bone Length Variation in MiceFrontiers in cell and developmental biologyJanuary 1, 0001"Marchini M, Ashkin MR, Bellini M, Sun MM, Workentine ML, Okuyan HM, Krawetz R, Beier F, Rolian C."1:20, 11198-1-AP, ProteinTech; KI67 1:100, ab15580, AbCam; NPR3 1:100, ab37617, AbCam; PRRX1 1:100, NBP1-06067, Novus Biologicals, RUNX2 1:400, ab192256, AbCam; SFRP1; 1:100, ab4193, AbCam; SOX9 1:300, AF3075, Bio-Techne).

(11) SETD2 loss in renal epithelial cells drives epithelial-to-mesenchymal transition in a TGF-β-independent mannerMolecular oncologyJanuary 1, 0001"Wang T, Wagner RT, Hlady RA, Pan X, Zhao X, Kim S, Wang L, Lee JH, Luo H, Castle EP, et al."(R&D Systems; #AF2018‐SP), OCT2 (Thermo Fisher; #39‐5400), PRRX1 (Novus Biologicals, St. Charles, MO, USA; #NBP1‐06067), anti‐FLAG (Sigma‐Aldrich; #F1804), GAPDH (Cell Signaling Technology; #2118S), and lamin B1 (Proteintech;

(12) Development of monoclonal antibodies to target the large surface protein of hepatitis B virus and their use in therapeutic and diagnostic applicationsJournal of viral hepatitisJanuary 1, 0001"Paul SS, Patwa SM, Tan YJ."

(13) Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biologyCancer researchJanuary 1, 0001"Kim YJ, Ahn JY, Liang P, Ip C, Zhang Y, Park YM."

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PRRX1 Antibody

PRRX1 Antibody

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PRRX1 Antibody

PRRX1 Antibody

PRRX1 Antibody from Novus Biologicals, a Bio-Techne Brand

Specifications/Features

Questions and Answers

Novus Biologicals, a Bio-Techne Brand

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PRRX1 Antibody from Novus Biologicals, a Bio-Techne Brand

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