MyBioSource.com's Mouse anti Integrin beta 4 (CD104) is a Mouse monoclonal antibody. The Mouse anti Integrin beta 4 (CD104) Antibody was generated using CD104, Integrin beta 4, and ITGB4 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - frozen, Immunoprecipitation, and Western Blot.
Description
CD104 (Cluster of Differentiation 104) is also known as Integrin, beta 4 (ITGB4). CD104 is a 205 kD type I transmembrane glycoprotein. Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. Integrin b4 (CD104) associates with integrin alpha6 (CD49f) forming the alpha6/beta4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the prolifeRative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells. CD49f/CD104 is an adhesion receptor for laminins (especially laminin 5) and keRatin filaments and is involved in the regulation of hemidesmosome formation and of cell prolifeRation and activation. CD104 is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene