MyBioSource.com's Rhodopsin (B630), Monoclonal Antibody, Mouse is a Mouse monoclonal antibody. It reacts with Human, Mouse, Rat, Bovine, and Porcine. This antibody has been shown to work in applications such as: Immunofluorescence, and Western Blot.
Description
Description: Rhodopsin is the protein in the mammalian retina responsible for the light sensitivity of rod cells, which are responsible for vision in low light levels. The rhodopsin protein is a member of the G protein-coupled receptor (GPCR) rhodopsin-like family. It exists with a the ligand bound subsatnce named retinal. Retinal can exist in two isomeric forms, 11-cis and 11-trans retinal. In the dark rhodopsin is associated with 11-cis retinal, but light causea the 11-cis form to flip to the 11-trans form, and this causes an alteration in the structure of the rhodopsin making it catalytically active resulting in a reduced rate of photoreceptor synaptic release. Activity is shut off by phosphorylation under the influence of rhodopsin kinase, the activity of which results in binding of visual arrestin (a.k.a. arrestin-1 and S-antigen), which prevents rhodopsin from interacting with and activating more transducin molecules