MafA Antibody NBP1-00121 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemMafA Antibody
CompanyNovus Biologicals, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberNBP1-00121
Conjugate/TagUnconjugated
ReactivityHuman,Mouse,Rat
ApplicationsIF/IHC,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence
Quantity0.1 ml
TargetMafA
FormatTBS and 0.1% BSA
HostRabbit
ImmunogenThe immunogen recognized by this antibody maps to a region between residue 300 and the C-terminus (residue 359) of mouse v-maf musculoaponeurotic fibrosarcoma oncogene homolog A using the numbering given in entry NP_919331.1 (GeneID 378435)
NCBI Full Gene NameMAF bZIP transcription factor A
NCBI Gene AliasesINSDM, RIPE3b1, hMafA
Concentration0.05 mg/ml
ClonalityPolyclonal
PurityImmunogen affinity purified
Research AreaDiabetes Research, Lipid and Metabolism, Transcription Factors and Regulators
IsotypeIgG
Antibody TypePrimary Antibodies
StorageStore at 4C. Do not freeze

Specifications/Features

Available conjugates: Unconjugated

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Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) LDB1-mediated transcriptional complexes are sensitive to islet stressIsletsDecember 31, 2022Liu Y, Kepple JD, Shalev A, S Hunter C.followed by incubation with α-LDB1 (sc-11198x, 1:1000; Santa Cruz Biotechnology, Inc), α-MAFA (1:1000, NBP1–00121, Novus), α-ISL1 (1:1000, 39.4D5-c; Developmental Studies Hybridoma Bank), or α-NKX6.1 (1:1000, F55A10-c;

(2) Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity ChangesDiabetesNovember 1, 2021Tong X, Stein R.Santa Cruz, CA), anti-FEV (rabbit, 1:400; Thermo Fisher Scientific), anti-MAFA (rabbit, 1:500, cat. no. NBP1-00121; Novus), and anti-NKX2.2 (anti-goat, 1:400, Santa Cruz Biotechnology). Species-matched antibodies conjugated

(3) Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in malesCell reportsOctober 12, 2021Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, et al.blocked in 2% normal donkey serum/1% BSA in PBS and incubated overnight with Rabbit α-MAFA (1:500, Novus (NBP1-00121) at 4°C. After washing, slides were mounted and imaged on a Zeiss Axio Imager M2 widefield microscope

(4) Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signalingThe Journal of clinical investigationJuly 1, 2020Shrestha N, Liu T, Ji Y, Reinert RB, Torres M, Li X, Zhang M, Tang CA, Hu CA, Liu C, et al.ab30788; 1:200), Aldh1a3 (Novus Biologicals, catalog NBP2-15339; 1:100), MafA (Novus Biologicals, catalog NBP1-00121; 1:100), Ucn3 (provided by Mark Huising (University of California, Davis, Davis, CA, USA); 1:1000), Pdx1

(5) Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca²⁺ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress ResponseDiabetesJune 1, 2020Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, et al.

(6) The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell FunctionDiabetesSeptember 1, 2019Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, et al.

(7) LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell functionThe Journal of biological chemistryAugust 2, 2019Wade AK, Liu Y, Bethea MM, Toren E, Tse HM, Hunter CS.

(8) mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetesThe Journal of clinical investigationJuly 2, 2019Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, et al.anti-insulin (A056401-2, Agilent), anti-Pdx1 (F109-D12, Developmental Studies Hybridoma Bank), and anti-MafA (NBP1-00121, Novus Biologicals). Briefly, pancreatic tissue was flushed with PBS, dissected, fixed in buffered zinc

(9) B lymphocytes protect islet β cells in diabetes prone NOD mice treated with imatinibJCI insightApril 9, 2019Wilson CS, Spaeth JM, Karp J, Stocks BT, Hoopes EM, Stein RW, Moore DJ.(Cell Signaling Technology, 2760; 1:2000); Ki-67 mouse (BD Pharmingen, 550609; 1:1,000); MafA (Novus Biologicals, NBP1-00121; 1:500); Nkx6.1 (Novus Biologicals, NBP1-49672; 1:500); Ucn3 (Phoenix Pharmaceuticals, H-019-29; 1:1000);

(10) Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca²⁺ Sensitivity of Insulin Secretion VesiclesDevelopmental cellMay 7, 2018Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, et al.

(11) Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During WeaningDiabetesNovember 1, 2017Spaeth JM, Gupte M, Perelis M, Yang YP, Cyphert H, Guo S, Liu JH, Guo M, Bass J, Magnuson MA, et al.NB600–266; Novus Biologicals, Littleton, CO); MafA (1:1,000; IHC-00352; Bethyl Laboratories); MafA (1:500; NBP1–00121; Novus Biologicals); Nkx6.1 (1:500; NBP1–49672; Novus Biologicals); Glut2 (1:500; sc-7580; Santa Cruz Biotechnology

(12) The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cellsAmerican journal of physiology. Endocrinology and metabolismJanuary 1, 2016Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, et al.

(13) SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target GenesMolecular endocrinology (Baltimore, Md.)December 1, 2015Galloway JR, Bethea M, Liu Y, Underwood R, Mobley JA, Hunter CS.

(14) MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell FunctionDiabetesNovember 1, 2015Scoville DW, Cyphert HA, Liao L, Xu J, Reynolds A, Guo S, Stein R.

(15) Characterization of age-associated alterations of islet function and structure in diabetic mutant cryptochrome 1 transgenic miceJournal of diabetes investigationSeptember 13, 2013Okano S, Hayasaka K, Igarashi M, Togashi Y, Nakajima O.anti‐glucagon antibody (1:100 Ab‐1; Thermo Fisher Scientific Inc., Waltham, MA, USA), rabbit anti‐MafA (1:100 NBP1‐00121; Novus Biologicals Inc., Littleton, CO, USA) and rabbit anti‐PDX‐1 (1:250 KR059; TransGenic Inc., Kumamoto,

(16) Two distinct origins for Leydig cell progenitors in the fetal testisDevelopmental biologyApril 1, 2011DeFalco T, Takahashi S, Capel B.

(17) Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetesDiabetesOctober 1, 2010Noso S, Kataoka K, Kawabata Y, Babaya N, Hiromine Y, Yamaji K, Fujisawa T, Aramata S, Kudo T, Takahashi S, et al.

(18) Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domainMolecular and cellular biologySeptember 1, 2010Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, et al.

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MafA Antibody

MafA Antibody

MafA Antibody

MafA Antibody from Novus Biologicals, a Bio-Techne Brand

Specifications/Features

Novus Biologicals, a Bio-Techne Brand

Citations (18)

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MafA Antibody from Novus Biologicals, a Bio-Techne Brand

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