The PSMD4 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PSMD4, pUb-R5, and RPN10. This antibody recognizes Human, Mouse, and Rat antigen. The PSMD4 Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
S5a (PSMD4) is a subunit of the 19S regulatory proteasome complex functioning in ubiquitinated-protein targeting and degradation (1). S5a contains two polyubiquitin binding motifs (UIM) that bind multiubiquitin chains by hydrophobic interaction (2,3). In addition to ubiquitin, the UIM of S5a shows high affinity to a ubiquitin-like domain present in many proteins. S5a binds to these types of proteins directly and mediates their targeting to the proteasome for degradation (4,5)