Fig 1: Chronic moderate drinking differentially alters NMDA and GABAA receptors in the cortex and hippocampus of APP/PS1 mice. a) Ethanol treatment did not alter cortical Grin2a expression in wildtype or APP/PS1 mice. b) Ethanol-treated APP/PS1 mice had higher cortical Grin2b expression compared to EtOH-treated wildtype mice. 2-way ANOVA revealed a significant treatment × genotype interaction (p = 0.0319). c) H2O-treated APP/PS1 mice showed increased cortical Gabra5 expression compared to H2O-exposed wildtype mice (p < 0.05). This effect was lost in EtOH-exposed APP/PS1 Gabra5 mRNA levels. 2-way ANOVA revealed a significant treatment × genotype interaction (p = 0.0249) and a trend in genotype effects (p = 0.0723). d) Synaptic GluN2A levels was unaltered in the hippocampus of H2O- or EtOH-treated wildtype or APP/PS1 mice. e) Synaptic GluN2B levels was unaltered in the hippocampus of H2O- or EtOH-treated wildtype or APP/PS1 mice. f) Ethanol-treated wildtype mice showed increased synaptic GABAAR a5 subunit levels compared to H2O-treated wildtype mice. Ethanol treatment had no effect on GABAAR a5 subunit levels in APP/PS1 mice. 2-way ANOVA revealed a significant treatment × genotype effect (p = 0.0347) and a trend in treatment effects (p = 0.0644). Wildtype + H2O, n = 10; APP/PS1 + H2O, n = 9; Wildtype + EtOH, n = 7; APP/PS1 + EtOH, n = 8. *p < 0.05.