CD38 Antibody AF4947 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemCD38 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF4947
ApplicationsFlow Cytometry,Immunohistochemistry,Western Blot,Simple Western,CyTOF-ready
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
TargetCD38
IsotypeIgG
Conjugate/TagUnconjugated
Quantity100 ug (also 25 ug)
HostSheep
ReactivityMouse,Transgenic Mouse
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse CD38, Leu45-Thr304, Accession # EDL37596
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene NameCD38 molecule
NCBI Gene AliasesADPRC 1, ADPRC1, cADPR1

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse CD38 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human CD38 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) CD38 Inhibition Ameliorates Age-Related Cognitive Decline via a Choroid Plexus–Cerebrospinal Fluid–Hippocampus AxisResearch SquareJanuary 6, 2026Eric Verdin, Jingqi Fang, Rebeccah Riley, Kevin Schneider, Rosalba Perrone, Prasanna Kumaar, Christina King, Grant Kauwe, Andrea Roberts, Genesis Vega Hormazabal, et al.incubated overnight at 4°C with primary antibodies: CD38 (1:200, Abcam ab216343; 1:500, R&D Systems AF4947), p21 (1:200, Abcam ab188224), HMGB1 (1:200, Cell Signaling 6893), TTR (1:500, Abcam ab215202; 1:200,

(2) CD38 is a key mediator of NAD+ depletion in the brain of ZIKV-infected miceiScienceDecember 19, 2025Georgia N. Saraiva, Bruna G. Sousa, Nicole M.S. Souza, Louise C. Vitorino, Raquel C. da Silva, Thiago S. Bacelar, Matheus O. Atella, Lorena O. Fernandes-Siqueira, Isis Nem de Oliveira Souza, Eduardo Nunes Chini, et al.nitrocellulose membranes (Bio-Rad, California, USA), and probed with primary antibodies against CD38 (AF4947, R&D Systems, Minnesota, USA) or NAMPT (AG-20A-0034-C050, AdipoGen Life Sciences, California, USA),

(3) Hepatocyte mitochondrial NAD+ content is limiting for liver regenerationNature MetabolismNovember 20, 2025Sarmistha Mukherjee, Ricardo A. Velázquez Aponte, Caroline E. Perry, Won Dong Lee, Kevin A. Janssen, Marc Niere, Gabriel K. Adzika, Mu-Jie Lu, Hsin-Ru Chan, Xiangyu Zou, et al.Technology, CS9441), anti-Poly/Mono-ADP Ribose (Cell Signaling Technology, CS89190), anti CD38 (R&D systems, AF4947) and HRP-conjugated β-actin (Abcam, ab49900). Mitochondrial proteins were also probed for anti-acetylated

(4) Role of CD38 in anti-tumor immunity of small cell lung cancerFront ImmunolMarch 12, 2024Hirokazu Taniguchi, Shweta S. Chavan, Andrew Chow, Joseph M. Chan, Hiroshi Mukae, Charles M. Rudin, Triparna Sen(Thermo Fisher) at room temperature for 1 hr and then incubated overnight with primary antibodies (CD38: R and D, AF4947, actin: Cell Singaling, # 4970)(1:1000) at 4°C. Incubation with horseradish peroxidase-linked secondary

(5) Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)iScienceNovember 18, 2022Zeidler JD, Chini CCS, Kanamori KS, Kashyap S, Espindola-Netto JM, Thompson K, Warner G, Cabral FS, Peclat TR, Gomez LS, et al.The following antibodies and their dilutions were used for immunoblotting: mouse CD38 (R&D Systems; AF4947, 1:1,000), CD45 (Abcam; AB40763; 1:1000), Phospholamban (PLN) (Invitrogen; MA3-922; 1:1000), CYP3a4

(6) LRRK2 is required for CD38-mediated NAADP-Ca²⁺ signaling and the downstream activation of TFEB (transcription factor EB) in immune cellsAutophagyJanuary 1, 2022Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH.Santa Cruz Biotechnology,sc-10087; 1:1000), MAP1LC3B (Cell Signaling Technology, 2775; 1:1000), CD38 (R&D Systems, AF4947; 1:2000), mouse-anti-FLAG (M2; Sigma-Aldrich, F1804; 1:1000), rabbit-anti-FLAG (Rockland, 600–401-383;

(7) Senescent cells promote tissue NAD⁺ decline during ageing via the activation of CD38⁺ macrophagesNature metabolismNovember 1, 2020Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, et al.Primary-antibody incubation was at 4 °C overnight. The sheep anti-CD38 polyclonal antibody (R&D Systems, cat. no. AF4947, diluted 1:100) and rabbit anti-F4/80 monoclonal antibody (Cell Signaling, cat. no. 70076, diluted 1:100)

(8) CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD⁺ and NMN levelsNature metabolismNovember 1, 2020Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarragó MG, Puranik AS, et al.antibodies were used for immunoblotting: human CD38 (Abcam – ab108403, 1:1000), mouse CD38 (R&D Systems–AF4947, 1:1000), Slc12a8 (Aviva Systems Biology-ARP44039, 1:1000), Actin (Cell Signaling Technology – 8457,

(9) The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD(+) declineBiochemical and biophysical research communicationsMay 28, 2019Chini C, Hogan KA, Warner GM, Tarragó MG, Peclat TR, Tchkonia T, Kirkland JL, Chini E.as previously described in Tarrago et al [9] using the following antibodies: mouse CD38 (R&D Systems AF4947) and β-Tubulin (Abcam Ab 15568). Enzymatic Activity. Measurement of CD38 hydrolase activity with nicotinamide

(10) Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of DemyelinationFrontiers in cellular neuroscienceJanuary 1, 2019Roboon J, Hattori T, Ishii H, Takarada-Iemata M, Le TM, Shiraishi Y, Ozaki N, Yamamoto Y, Sugawara A, Okamoto H, et al.membranes. The membranes were then blocked in 5% skimmed milk for 30 min, incubated with anti-CD38 (AF4947, R&D systems, MN, United States, 1:500), anti-glial fibrillary acidic protein (GFAP) (G9269, Sigma,

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CD38 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (10)

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CD38 Antibody from R&D Systems, a Bio-Techne Brand

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