Desmin Antibody AF3844 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemDesmin Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF3844
NCBI Gene AliasesLGMD2R, CDCD3, LGMD1E, LGMD1D, CSM1, CSM2
ApplicationsBioassay,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry
Quantity100 ug (also 25 ug)
IsotypeIgG
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityHuman,Mouse,Transgenic Mouse
TargetDesmin
HostGoat
NCBI Full Gene Namedesmin
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant human Desmin, Val261-Leu470, Accession # P17661
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human and mouse Desmin.

Sizes Available: 100 ug (also 25 ug)

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Questions and Answers

Can this antibody be used for immunofluorescence staining in my liver cell experiments?

Yes, the Desmin Antibody has been successfully utilized in immunofluorescence staining, as demonstrated in studies involving liver cells. For instance, in one study, cells were fixed and stained with the Desmin Antibody (AF3844) to analyze cellular structures during liver differentiation processes ().

Is this antibody effective for detecting desmin in cardiac tissue?

The Desmin Antibody has been shown to work effectively in immunohistochemistry for cardiac tissues. In a study investigating a desmin mutation associated with restrictive cardiomyopathy, the antibody was used to label desmin in myocardial tissue sections, confirming its utility in cardiac research ().

What species does this antibody react with, and is it suitable for mouse models?

The Desmin Antibody is reactive with both human and mouse desmin, making it suitable for studies involving mouse models. This reactivity has been confirmed in various applications, including Western blotting and immunohistochemistry (, ).

Are there any specific applications in which this antibody has been cited in the literature?

Yes, the Desmin Antibody has been cited in multiple applications, including Western blotting, immunocytochemistry, and immunohistochemistry. It has been referenced in studies focusing on liver cell differentiation, cardiac myopathy, and pericyte behavior in tumor environments, indicating its versatility in various research contexts (, ).

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Density-Adjusted Analysis of Cell Interactions to Decipher Tissue Landscape ChangesiScienceJune 19, 2026Misha Siddiqui, Azam Hamidinekoo, Jennifer Y. Tan, Renata Leke, Bader Zarrouki, Nick Trahearn, Yeman Brhane Hagos, Chirine Sakr, Andrea Lampis, Christopher Bagnall, et al.Francisco, CA, US",Cat#3151010B; RRID:AB_3677853 Desmin (IMC),"R&D systems, Minneapolis, MN, US",Cat#AF3844; RRID:AB_2092419 CD11c (IMC),"Cell signaling Technology, Danvers, MA, US",Cat#97585; RRID:AB_2800282 CD11b

(2) A mouse-adapted Yezo virus model for antiviral testing in immunocompetent miceNature communicationsMarch 17, 2026Xu W, Wang Y, Pan M, Tan Q, Jin F, Sui L, Zhao Y, Liu N, Liu Q.antibodies used in this study were as follows: anti-albumin (AF3329), anti-CD31 (AF3628), and anti-desmin (AF3844) (R&D Systems, USA); anti-F4/80 (ab320060) (Abcam, USA); anti-NLRP3 (15101S), anti-beta-Actin (4970S),

(3) Temporal proteomic profiling of iPSC-derived human liver organoids reveals optimal maturation for drug metabolism and toxicologyScientific reportsJanuary 14, 2026Yang S, Hao J, Ooka M, Xia M.(Abcam, ab181598, 1:1000), CYP3A4 (Invitrogen Antibodies, MA5-17064, 1:1000), desmin (R&D Systems, AF3844, 1:20), and albumin (Fortis Life Sciences, A80-129 A, 1:1000). The secondary antibodies are highly cross-adsorbed

(4) Microtubule forces drive nuclear damage in LMNA cardiomyopathyNature Cardiovascular ResearchOctober 10, 2025Daria Amiad Pavlov, Julie Heffler, Carmen Suay-Corredera, Mohammad Dehghany, Kaitlyn M. Shen, Noam Zuela-Sopilniak, Rani Randell, Keita Uchida, Rajan Jain, Vivek Shenoy, et al.anti-α-tubulin, Sigma-Aldrich, T5168, clone B-5-1-2, 1:50, and goat polyclonal anti-desmin, R&D Systems, AF3844, 1:250), at room temperature, in a homemade humidified chamber. Sections were rinsed in 1× PBS and washed

(5) Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticityNature communicationsJuly 13, 2024Quach H, Farrell S, Wu MJM, Kanagarajah K, Leung JW, Xu X, Kallurkar P, Turinsky AL, Bear CE, Ratjen F, et al.

(6) Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosisScience advancesJune 28, 2024Khanal S, Liu Y, Bamidele AO, Wixom AQ, Washington AM, Jalan-Sakrikar N, Cooper SA, Vuckovic I, Zhang S, Zhong J, et al.(Santa Cruz Biotechnology, #sc-15363), collagen 1 (Southern Biotech, #1310-01), desmin (R&D Systems, #AF3844), GAPDH (Invitrogen, #AM4300), HSC70 (Santa Cruz Biotechnology, sc7298), HK2 (Cell signaling, #2867),

(7) Molecular Analysis of a Congenital Myasthenic Syndrome Due to a Pathogenic Variant Affecting the C-Terminus of ColQInternational journal of molecular sciencesNovember 11, 2023Barbeau S, Semprez F, Dobbertin A, Merriadec L, Roussange F, Eymard B, Sternberg D, Fournier E, Karasoy H, Martinat C, et al.

(8) HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosisHepatology CommunicationsNovember 6, 2023Yi Huang, Suthat Liangpunsakul, Swetha Rudraiah, Jing Ma, Santosh K. Keshipeddy, Dennis Wright, Antonio Costa, Diane Burgess, Yuxia Zhang, Nazmul Huda, et al.Co-staining of HMGB2 and Desmin or α-SMA used rabbit anti-HMGB2 (ab 67282, Abcam), goat anti-Desmin (AF3844, R&D systems), and mouse anti-α-SMA (ab7817, Abcam). The secondary antibodies of goat anti-rabbit Alexa

(9) HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosisHepatol CommunNovember 6, 2023Yi Huang, Suthat Liangpunsakul, Swetha Rudraiah, Jing Ma, Santosh K. Keshipeddy, Dennis Wright, Antonio Costa, Diane Burgess, Yuxia Zhang, Nazmul Huda, et al.Co-staining of HMGB2 and Desmin or α-SMA used rabbit anti-HMGB2 (ab 67282, Abcam), goat anti-Desmin (AF3844, R&D systems), and mouse anti-α-SMA (ab7817, Abcam). The secondary antibodies of goat anti-rabbit Alexa

(10) Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracingCell stem cellNovember 2, 2023He S, Guo Z, Zhou M, Wang H, Zhang Z, Shi M, Li X, Yang X, He L.

(11) SARS-CoV-2 infection of kidney tissues from severe COVID-19 patientsJournal of medical virologyFebruary 1, 2023Radovic S, Meng W, Chen L, Paniz Mondolfi AE, Bryce C, Grimes Z, Sordillo EM, Cordon-Cardo C, Guo H, Huang Y, et al.(1:500, Proteintech, 66379-1-lg), CD34 (1:500, Invitrogen, MA1-10202), Desmin (1:100, R&D Systems, AF3844), CD68 (1:1,000, Invitrogen, 14-0688-82), CD56 (1:25, R&D Systems, AF2408), CD20 (1:100, eBioscience,

(12) Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathyCell communication and signaling : CCSJuly 28, 2022Li L, Feng Y, Zhang J, Zhang Q, Ren J, Sun C, Li S, Lei X, Luo G, Hu J, et al.(R and D Systems Cat# AF3159, RRID:AB_2155023, Minneapolis, MN, USA), Desmin (R and D Systems Cat# AF3844, RRID:AB_2092419). Apoptosis assay In Situ Cell Death Detection Kit, fluorescein (Cat# 11684795910,

(13) A combined human gastruloid model of cardiogenesis and neurogenesisiScienceJune 17, 2022Olmsted ZT, Paluh JL.anti-Phospho Tau (Ser214),Invitrogen,Cat.No.: 44-742G; RRID: AB_2533740 Goat anti-Desmin,R&D Systems,Cat.No.: AF3844; RRID: AB_2092419 Mouse anti-cardiac Troponin T,R&D Systems,Cat.No.: MAB1874; RRID: AB_2206731 ,, "Chemicals,

(14) Chemerin regulates normal angiogenesis and hypoxia-driven neovascularizationAngiogenesisMay 1, 2022Ben Dhaou C, Mandi K, Frye M, Acheampong A, Radi A, De Becker B, Antoine M, Baeyens N, Wittamer V, Parmentier M.anti-mouse collagen IV (1:400, Bio-Rad, 2150−1470), goat polyclonal anti-desmin (1:100, R&D Systems, AF3844), goat polyclonal anti-mouse PDGFRβ (1:100, R&D Systems, AF1042), mouse monoclonal anti-BrdU (1:100,

(15) Long-term and potent IOP-lowering effect of IκBα-siRNA in a nonhuman primate model of chronic ocular hypertensioniScienceApril 15, 2022Sun D, Zhan Z, Zeng R, Liu X, Wang B, Yang F, Huang S, Li Y, Yang Z, Su Y, et al.actin (α-SMA),Bioss,Cat# bsm-33187M;RRID: AB_2910163 goat polyclonal anti-desmin,R&D Systems,Cat# AF3844; RRID: AB_2092419 rabbit anti-RSPO4,Bioss,Cat# bs-18878R; RRID: AB_2910164 rabbit polyclonal anti-NSE,Bioss,Cat#

(16) Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine ModelCellular and molecular gastroenterology and hepatologyJanuary 1, 2022Ceci L, Chen L, Baiocchi L, Wu N, Kennedy L, Carpino G, Kyritsi K, Zhou T, Owen T, Kundu D, et al.(Danvers, MA)" CRY1,IF,Rabbit polyclonal,PA1-527,"Invitrogen (Waltham, MA)" Desmin,IF,Goat polyclonal,AF3844,"R&D Systems (Minneapolis, MN)" F4/80,IHC,Rabbit monoclonal,70076S,"Cell Signaling (Danvers, MA)" GAPDH-HRP

(17) The Desmin Mutation DES-c.735G>C Causes Severe Restrictive Cardiomyopathy by Inducing In-Frame Skipping of Exon-3BiomedicinesOctober 5, 2021Brodehl A, Hain C, Flottmann F, Ratnavadivel S, Gaertner A, Klauke B, Kalinowski J, Körperich H, Gummert J, Paluszkiewicz L, et al.was used for blocking (30 min, room temperature). Polyclonal goat anti-desmin antibodies (15 µg/mL, #AF3844, R&D Systems, Minneapolis, MN, USA) were used in combination with secondary anti-goat antibodies conjugated

(18) Combined Treatment with Acalabrutinib and Rapamycin Inhibits Glioma Stem Cells and Promotes Vascular Normalization by Downregulating BTK/mTOR/VEGF SignalingPharmaceuticals (Basel, Switzerland)August 29, 2021Su YK, Bamodu OA, Su IC, Pikatan NW, Fong IH, Lee WH, Yeh CT, Chiu HY, Lin CM.included CD31 (endothelial cells; 1:200; MAB1398Z; EMD Millipore), desmin (perivascular cells; 1:500; AF3844; R&D Systems), collagen IV (BM; 1:2000; AB7569; EMD Millipore), and Alexa Fluor 647-conjugated F4/80

(19) Hepatic stellate and endothelial cells maintain hematopoietic stem cells in the developing liverThe Journal of experimental medicineMarch 1, 2021Lee Y, Leslie J, Yang Y, Ding L.(L9393; Sigma-Aldrich), rabbit-anti-Desmin antibody (GTX103557; GeneTex), goat-anti-Desmin antibody (AF3844; R&D Systems) rabbit-anti-HNF4α antibody (ab201460; Abcam), goat-anti-VE-cadherin antibody (BAF1002;

(20) Extreme Diversity of the Human Vascular Mesenchymal Cell LandscapeJournal of the American Heart AssociationDecember 1, 2020Bruijn LE, van den Akker BEWM, van Rhijn CM, Hamming JF, Lindeman JHN.

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Desmin Antibody

Desmin Antibody

Desmin Antibody

Desmin Antibody

Desmin Antibody

Desmin Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

Questions and Answers

R&D Systems, a Bio-Techne Brand

Citations (44)

Reviews

Desmin Antibody from R&D Systems, a Bio-Techne Brand

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