CHIP (C3B6) Rabbit mAb from Cell Signaling Technology

The CHIP (C3B6) Rabbit mAb detects endogenous levels of total CHIP protein and is reactive with mouse, non-human primate, human, and rat. It has been cited in 57 scientific articles, indicating its utility in various research contexts.

Yes, the CHIP antibody has been shown to work in immunoprecipitation experiments. For instance, in the study by Albert et al. (2020), the antibody was utilized to investigate the role of CHIP in the ubiquitylation and degradation of the protein NOXA in response to DNA damage, highlighting its functional application in protein interaction studies.

The CHIP antibody has been used to explore the regulation of protein stability, such as in the study by Seo et al. (2021), where it was shown that CHIP interacts with the INO80 complex to stabilize it, thereby influencing DNA replication processes. This underscores the antibody's role in elucidating mechanisms of protein quality control.

The CHIP antibody has been effectively used in Western blotting and immunoprecipitation applications, as demonstrated in multiple studies, including those investigating the degradation pathways of proteins like NOXA and the stabilization of oncogenic proteins in cancer research. These applications highlight its versatility in studying ubiquitin-proteasome pathways and protein interactions.