Rheb Antibody (2C11)

Product Specs
ItemRheb Antibody (2C11) - Azide and BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $539.00Supplier Page View Company Product Page
Catalog NumberH00006009-M01
ImmunogenRHEB (AAH16155, 1 a.a. ~ 184 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MPQSKSRKIA ILGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKLITVN GQEYHLQLVD TAGQDEYSIF PQTYSIDING YILVYSVTSI KSFEVIKVIH GKLLDMVGKV QIPIMLVGNK KDLHMERVIS YEEGKALAES WNAAFLESSA KENQTAVDVF RRIILEAEKM DGAASQGKSS CSVM
TargetRheb
FormatIn 1x PBS, pH 7.4
ReactivityHuman,Mouse,Rat
ClonalityMonoclonal
Conjugate/TagUnconjugated
ApplicationsELISA,Western Blot,Immunocytochemistry/ Immunofluorescence
IsotypeIgG1 Kappa
Quantity0.1 mg
Clone2C11
HostMouse
NCBI Full Gene NameRas homolog, mTORC1 binding
PurityIgG purified
Research AreaCancer, mTOR Pathway, Signal Transduction
Antibody TypePrimary Antibodies
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles
NCBI Gene AliasesRHEB2

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: RHEB - Ras homolog enriched in brain (2C11)

Sizes Available: 0.1 mg

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Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesisCell reportsOctober 28, 2025Ikeda T, Hong S, Yoshida S, Srivastava SP, Kunamneni A, Yao Y, Khuperkar O, Basrur V, Kuang H, Kachman M, et al.

(2) The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activationCell reportsJanuary 28, 2025Yao Y, Hong S, Yoshida S, Swaroop V, Curtin B, Inoki K.11905-1-AP; RRID:AB_10697836 Mouse monoclonal anti-Rheb (clone 2C11) (for WB),Novus Biologicals,Cat#H00006009-M01; RRID:AB_1112097 Rabbit polyclonal anti-GST,Novus Biologicals,Cat#NB600-326; RRID:AB_10001229 Rabbit

(3) Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibitionNature cell biologySeptember 1, 2022Figlia G, Müller S, Hagenston AM, Kleber S, Roiuk M, Quast JP, Ten Bosch N, Carvajal Ibañez D, Mauceri D, Martin-Villalba A, et al.

(4) Rheb regulates nuclear mTORC1 activity independent of farnesylationCell chemical biologyJune 16, 2022Zhong Y, Zhou X, Guan KL, Zhang J.

(5) Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase ActivityMolecular cellNovember 5, 2020Yao Y, Hong S, Ikeda T, Mori H, MacDougald OA, Nada S, Okada M, Inoki K.Odyssey blocking buffer and 0.2 % Triton X-100-containing PBS with the following dilution: Rheb (Cat. NO. H00006009-M01, 1:200, Novus Biologicals); p-S6 S235/6 (#4857, 1:500, Cell Signaling). Cells were incubated with the

(6) GPCR signaling inhibits mTORC1 via PKA phosphorylation of RaptoreLifeMay 21, 2019Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, et al.

(7) Ubiquitination of Rheb governs growth factor-induced mTORC1 activationCell researchFebruary 1, 2019Deng L, Chen L, Zhao L, Xu Y, Peng X, Wang X, Ding L, Jin J, Teng H, Wang Y, et al.

(8) RHEB1 insufficiency in aged male mice is associated with stress-induced seizuresGeroScienceDecember 1, 2017Tian Q, Gromov P, Clement JH, Wang Y, Riemann M, Weih F, Sun XX, Dai MS, Fedorov LM.

(9) The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide LevelsCell reportsOctober 31, 2017Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD.

(10) Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signalingThe Journal of biological chemistryApril 28, 2017Jacobs BL, McNally RM, Kim KJ, Blanco R, Privett RE, You JS, Hornberger TA.

(11) p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and RhebMolecular cancer research : MCRJanuary 1, 2016Agarwal S, Bell CM, Taylor SM, Moran RG.

(12) Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosomeCellFebruary 13, 2014Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD.

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Rheb Antibody (2C11) - Azide and BSA Free from Novus Biologicals, a Bio-Techne Brand

Specifications/Features

Novus Biologicals, a Bio-Techne Brand

Citations (12)

Reviews

Rheb Antibody (2C11) - Azide and BSA Free from Novus Biologicals, a Bio-Techne Brand

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