Cdk1/Cdk2 (AN21.2) Antibody sc-53219 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemCdk1/Cdk2 (AN21.2) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-53219
Antibody TypePrimary Antibodies
NCBI Gene AliasesCDC28A, A630093N05Rik, p33(CDK2), CDKN2, p34<CDC2>, P34CDC2, CDC2, Cdc2, Cdc2a
Quantity200 µg/ml
CloneAN21.2
Reactivitymouse, rat, human
ApplicationsWB, IP, IF, IHC(P)
FormatPurified
Conjugate/TagUnconjugated
Hostmouse
NCBI Full Gene Namecyclin dependent kinase 1, cyclin dependent kinase 2
IsotypeIgG2a
TargetCdk2
ClonalityMonoclonal

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) A 3D Graphene Oxide Model Reveals Fine Particulate Matter Induced Cell Cycle Dysregulation in Neural Stem CellsToxicsJune 21, 2026Siqi Li, Huiyun Chang, Mengjie Gao, Wenlou Zhang, Furong Deng, Fengge Chen, Xiaoman Zhu, Yu Song, Hong Zhang, Shaojie Liu, et al.Santa Cruz, USA), Cyclin E (sc-377100, Santa Cruz, USA), Cdk2, Cdk4 (sc-23896, Santa Cruz, USA), Cdk1/Cdk2 (sc-53219, Santa Cruz, USA), APC (sc-53166, Santa Cruz, USA), Cdc20 (sc-53398, Santa Cruz, USA) and β-actin (sc-517582,

(2) CASK promotes non-small cell lung cancer growth through coordinated regulation of EGFR expression, trafficking, and p21 expressionJ Biomed SciMay 9, 2026Yun-Han Lai, Duen-Yi Huang, Yen-Yu Chang, Yen-Lin Huang, Wan-Wan Lin(sc-13158), ERK (sc-271269), EGFR (sc-120), p21 (sc-53870), β-actin (sc-47778), cyclin B (sc-166210), CDK1 (sc-53219), cyclin D1 (sc-718), and acetylated α-tubulin (sc-23950) were obtained from Santa Cruz (Santa Cruz,

(3) GSK3i combinatorial treatments affect CDK4/6 and compensatory pathways in 3D preclinical models of pancreatic neuroendocrine tumorsBiology OpenMarch 15, 2026Edlira Luca, Igor Shapiro, Huguette Debaix, Kathrin Zitzmann, Katharina Wang, Christoph J. Auernhammer, Felix Beuschlein, Svenja Nölting, Constanze HantelCell Signaling Technology (Danvers, MA, USA)",1:500 CDK6,"sc-7961, Santa Cruz Biotechnology (USA)",1:100 CDK 1/2,"sc-53219, Santa Cruz Biotechnology (USA)",1:100 phospho-Chk2,"2197, Cell Signaling Technology (Danvers, MA,

(4) USP1 driven mitotic dysregulation and PLK1 stabilization confer Lenvatinib resistance in hepatocellular carcinomaJournal of Experimental & Clinical Cancer ResearchMarch 13, 2026Yuwei Qiang, Saiyan Bian, Yun Tong, Weiting Chen, Zhangzhi Tang, Chengchen Dai, Mingyu Liu, Banglong Xu, Lihan Jiang, Kexin Ma, et al.Cat#AE005, 1:500 v/v), anti-Cyclin B1 (Santa Cruz, Cat#sc245, 1:500 v/v), anti-CDK1 (Santa Cruz, Cat#sc53219, 1:500 v/v), anti-STUB1 (Santa Cruz, Cat#sc133066, 1:500 v/v), anti-c-Myc (Abclonal, Cat#A1309, 1:1000

(5) Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastomaiScienceFebruary 20, 2026Anna S. Kolodziejczak, Florian Selt, Heike Peterziel, Nora Jamaladdin, Norman Mack, Kendra Maaß, Chris Meulenbroeks, Romain Sigaud, Christel Herold-Mende, Ahmed El Damaty, et al.were used: α-CDK1 (phospho Y15) [BLR101H] (cat.no. ab275958, Abcam), α-Cdk1/Cdk2 (AN21.2) (cat.no. sc-53219, Santa Cruz Biotechnology, Inc.), α-HSP90 (cat.no. 4877, Cell Signaling Technology). Western blot bands

(6) Discovery of dCDK9-202 as a Highly Potent and Selective PROTAC CDK9 Degrader with Strong In Vivo Antitumor ActivityJ Med ChemOctober 23, 2025Lin Ma, Long Xie, Yue Wang, Xian Guan, Ying Zhang, Hanjun Guo, Jiawei Zhou, Jiyang Liu, Xingze Huang, Chunyu He, et al.sc-13130), ACTIN (Proteintech, 66009-1-Ig), GAPDH (Cell Signaling Technology, 2118), CDK1/2 (Santa Cruz, sc-53219), CDK4 (Cell Signaling Technology, 12790), CDK5 (Santa Cruz, sc-173), CDK6 (Cell Signaling Technology,

(7) Repurposing HIV-Protease Inhibitor Precursors as Anticancer Agents: The Synthetic Molecule RDD-142 Delays Cell Cycle Progression and Induces Autophagy in HepG2 Cells with Enhanced Efficacy via Liposomal FormulationInternational Journal of Molecular SciencesOctober 23, 2025Fabiana Crispo, Antonio Vassallo, Immacolata Faraone, Alessandro Santarsiere, Lucia Chiummiento, Mara Martinelli, Nicoletta Cascelli, Xavier Fernàndez-Busquets, Rocchina Miglionico, Ilaria Nigro, et al.conveniently diluted in Tween-Phosphate-Buffered Saline (T-PBS) as reported in the datasheet: CDK1/2 (sc-53219, Santa Cruz Biotechnology, Dallas, TX, USA), Cyclin B1 (sc-166757, Santa Cruz Biotechnology), LC3B (#2775S,

(8) Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathwayPeerJMarch 31, 2025Jia Song, Jinyu Qiao, Mingxue Chen, Jiahui Li, Jixia Wang, Dayong Yu, Huachuan Zheng, Liying Shiantibodies: anti-Bcl-2 (Cat# sc-73822), anti-Bax (Cat# sc-20067), anti-Bid (Cat# sc-56025), anti-CDK1 (Cat# sc-53219), anti-CCNB1 (Cat# sc-53238), anti-ERK (Cat# sc-81459), anti-JNK (Cat# sc-7345) and anti-GAPDH (Cat#

(9) STEAP4 with copper reductase activity suppresses tumorigenesis by regulating the cell cycle in hepatocellular carcinoma cellsCell DivisionDecember 24, 2024Ting Yang, Minhong Zou, Yujie Xie, Yong Zhang, Kun Wang, Shihai Jiang, Qiong ZouGermany), anti-CDC25C antibody (16485-1-AP, 1:2000, proteintech, Germany) and anti-CDK1/CDK2 antibody (sc-53219, 1:2000, Santa Cruz, Germany). Samples were then washed five times with TBST and incubated with appropriate

(10) Transcriptome Analysis of Platelet‐Rich Plasma–Treated Osteoarthritic ChondrocyteBioMed Research InternationalNovember 21, 2024Dae Keun Suh, Woo Jin Yeo, Kuhoang Cheong, Jae-Won Heo, Dong Hyeon Kim, Soo Mi Lee, Yong-Soo Lee, Dong Won Suhanti-11β-HSD1 (AF3397, R&D system, Minneapolis, MN, USA), anti-Ki-67 (MA5-14520, Invitrogen), anti-CDK1/CDK2 (sc53219, Santa Cruz), and anti-GAPDH (sc32233, Santa Cruz) antibodies. Immunoreactive proteins were assessed

(11) Non-canonical deubiquitination of OTUB1 induces IFNγ-mediated cell cycle arrest via regulation of p27 stabilityOncogeneJune 10, 2024Seul Gi Lee, Seon Min Woo, Seung Un Seo, Hyun Shik Lee, Sang Hyun Kim, Young-Chae Chang, Hyo Je Cho, Simmyung Yook, Ju-Ock Nam, Taeg Kyu Kwonfollowing antibodies were used: p27 (sc-1641), p21 (sc-6246), Ub (sc-8017), OTUB1 (sc-130458), CDK1 (sc-53219), CDK2 (sc-163), CDK4 (sc-260), CDK6 (sc-117), Cyclin A (sc-751), Cyclin D (sc-450), Cyclin E (sc-247),

(12) Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myelomaNat CommunMarch 21, 2024Daniel A. Ang, Jean-Michel Carter, Kamalakshi Deka, Joel H. L. Tan, Jianbiao Zhou, Qingfeng Chen, Wee Joo Chng, Nathan Harmston, Yinghui Li(2524S; CST, 1:1000), p-p53 (sc-377567; Santa Cruz, 1:500), GRAP2 (sc-73652; Santa Cruz, 1:500), cdc2 (sc-53219; Santa Cruz, 1:500) and Bax (sc-7480; Santa Cruz, 1:500) mouse monoclonal antibody. Binding was detected

(13) UBE2C is a diagnosis and therapeutic biomarker involved in immune infiltration of cancers including lung adenocarcinomaJournal of CancerJanuary 27, 2024Daxia Cai, Feng Tian, Minhua Wu, Jianfei Tu, Yonghui Wanganti-p-mTOR (1:1000; CST5536), anti-mTOR (1:1000; CST2972), CDK1/2 (AN21.2, Santa Cruz Biotechnology, sc-53219), PCNA (PC10, Santa Cruz Biotechnology, sc-56), MCM2 (E-8, Santa Cruz Biotechnology, sc-373702), MCM4(G-7,

(14) Curcumol β-cyclodextrin inclusion complex enhances radiosensitivity of esophageal cancer under hypoxic and normoxic conditionJapanese Journal of RadiologyNovember 1, 2023Meng Su, Xiaolin Ren, Dexi Du, Huijuan He, Dahai Zhang, Raoying Xie, Xia Deng, Changlin Zou, Haizhou ZouCell Signaling Technology (Beverly, MA, USA). Antibodies against cyclin B1 (sc‑7393), CDK1 (cyclin-dependent kinase 1, sc‑53219), Ku86 (sc‑5280), Ku70 (sc‑17789), Rad51 (sc‑133089), and Rad54 (sc-374598) were purchased from Santa Cruz Biotechnology

(15) DNA framework-engineered chimeras platform enables selectively targeted protein degradationNature communicationsJuly 27, 2023Zhou L, Yu B, Gao M, Chen R, Li Z, Gu Y, Bian J, Ma Y.IL, USA, 11705-1-AP, 1:1000), mouse CDK1/2 (AN21.2) monoclonal antibody (Santa Cruz Biotechnology, sc-53219, 1:250), mouse CDK6 antibody (Proteintech Group, Rosemont, IL, USA, 66278-1-Ig, 1:1000), rabbit ERG

(16) PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functionsCell death and differentiationApril 1, 2023Chen J, Li M, Liu Y, Guan T, Yang X, Wen Y, Zhu Y, Xiao Z, Shen X, Zhang H, et al.(sc-8017, dilution: 1:500), VHL (sc-135657, dilution: 1:500), CDK7 (sc-7344, dilution: 1:500), CDK2 (sc-53219, dilution: 1:500), WSB1 (sc-393200, dilution: 1:500) and CDK1 (sc-54, dilution: 1:500) were purchased

(17) The brain-penetrant cell-cycle inhibitor p28 sensitizes brain metastases to DNA-damaging agentsNeuro-oncology advancesJanuary 1, 2023Mander S, Gorman GS, Coward LU, Christov K, Green A, Das Gupta TK, Yamada T.#SC-397), Cyclin A (Biosource, #AHF0022), Cyclin E (Biosource, #AHF0312), CDK1 (Santa Cruz Biotechnology, #SC-53219), CDK2 (Santa Cruz Biotechnology, #SC-163), ATP5a (Santa Cruz Biotechnology, #SC-136178) and actin (Santa Cruz Biotechnology

(18) A Mechanism of Isoorientin-Induced Apoptosis and Migration Inhibition in Gastric Cancer AGS CellsPharmaceuticals (Basel, Switzerland)December 12, 2022Zhang T, Xiu YH, Xue H, Li YN, Cao JL, Hou WS, Liu J, Cui YH, Xu T, Wang Y, et al.

(19) Targeting SPHK1/PBX1 Axis Induced Cell Cycle Arrest in Non-Small Cell Lung CancerInternational journal of molecular sciencesOctober 22, 2022Lin Z, Li Y, Han X, Fu Z, Tian Z, Li C.(1:1000, Santa Cruz Biotechnology, sc-6248, Dallas, TX, USA), CDK1/CDK2 (1:1000, Santa Cruz Biotechnology, sc-53219, Dallas, TX, USA), CyclinD1 (1:1000, Santa Cruz Biotechnology, sc-8396, Dallas, TX, USA), β-actin (1:1000,

(20) Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signalingBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieSeptember 1, 2022Chen HL, Lo YH, Lin CL, Lee TH, Leung W, Wang SW, Lin IP, Lin MY, Lee CH.

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Cdk1/Cdk2 (AN21.2) Antibody

Cdk1/Cdk2 (AN21.2) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Cdk1/Cdk2 (AN21.2) Antibody from Santa Cruz Biotechnology, Inc.

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