Fig 1: Pathologic findings of DLBCL with expression of five candidate genes. (A) BLS-type DLBCL shows patchy or interstitial infiltration by tumor cells in the bone marrow without sinusoidal involvement (HE stain, 100X). The centroblast-like tumor cells show large, vesicular nuclei with one to several prominent nucleoli (inset, 400X). (B) Immunohistochemical analysis showed that the lymphoma cells involving bone marrow express NANOG in the cytoplasm in contrast to the negative hematopoietic elements (100X; inset, 400X). (C) Lymphoma cells in this nodal case are positive for HOXA9 in nuclei (100X; inset, 400X). (D) S100A8 (MRP8) is positive in the cytoplasm of tumor cells of a nodal case (400X). (E) This case of BLS-type DLBCL involving bone marrow expresses cytoplasmic BMP8B (400X). (F) This nodal case expresses CCR6 in cytoplasm (400X).