IL-34 Antibody MAB5195 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-34 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $599.00Supplier Page View Company Product Page
Catalog NumberMAB5195
Quantity500 ug (also 25 ug)
ApplicationsNeutralization
Conjugate/TagUnconjugated
ReactivityMouse
TargetIL-34
IsotypeIgG2a
Clone780310
HostRat
NCBI Full Gene Nameinterleukin 34
NCBI Gene AliasesIL-34, 2010004A03Rik, C16orf77
ClonalityMonoclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse IL-34, Asn21-Pro235, Accession # Q8R1R4
PurityProtein A or G purified from hybridoma culture supernatant
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse IL-34 in ELISAs. In direct ELISAs, no cross-reactivity with recombinant human IL-34 is observed.

Sizes Available: 500 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) IL-34-mediated fibroblast-like synoviocyte-macrophage crosstalk drives bone erosion in rheumatoid arthritis through RANKL-dependent osteoclastogenesisFrontiers in ImmunologyJune 17, 2026Xin Li, Yurou Yang, Shuao Zhang, Yujing Cai, Aiqi Wang, Na Xuanimals were administrated with equivalent sterilized saline. IL-34 neutralizing antibody (catalog # MAB5195; R&D Systems, USA) and Isotype IgG were intraperitoneally injected at the dose of 10 mg/kg on day 24,

(2) A CD138+ tumor-associated macrophage/Siglec-F+ neutrophil feed-forward loop promotes immune evasion in pancreatic cancerJournal of Clinical InvestigationMay 1, 2026Chao Wang, Qi Zhang, Jinyan Huang, Fangyu Lin, Danyang Zhao, Youling Mu, Junshuo Tong, Jinping Li, Yingjiqiong Liang, Tao Zeng, et al.treatment in vivo. Mice were intraperitoneally injected with 200 μg of anti–IL-34 antibody (catalog MAB5195, R&D Systems) every other day, totaling 6 doses, starting on day 9 after the orthotopic inoculation

(3) A CD138+ tumor-associated macrophage/Siglec-F+ neutrophil feed-forward loop promotes immune evasion in pancreatic cancerJ Clin InvestMarch 12, 2026Chao Wang, Qi Zhang, Jinyan Huang, Fangyu Lin, Danyang Zhao, Youling Mu, Junshuo Tong, Jinping Li, Yingjiqiong Liang, Tao Zeng, et al.treatment in vivo. Mice were intraperitoneally injected with 200 μg of anti–IL-34 antibody (catalog MAB5195, R&D Systems) every other day, totaling 6 doses, starting on day 9 after the orthotopic inoculation

(4) Tumors hijack macrophages for iron supply to promote bone metastasis and anemiaCellOctober 30, 2025Yujiao Han, Hirak Sarkar, Zhan Xu, Sereno Lopez-Darwin, Yong Wei, Xiang Hang, Fengshuo Liu, Kimberley Tran, Wei Wang, Jennifer M. Miller, et al.migration, neutralizing antibodies against CCL5 (R&D Systems, #AF478, 500 ng/ml) and IL34 (R&D Systems, # MAB5195, 500 ng/ml) or small-molecule inhibitors targeting CSF1R (Sotuletinib/BLZ945, MCE, #HY-12768, 67 nM)

(5) Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic NeurodegenerationFrontiers in immunologyJanuary 1, 2020Obst J, Simon E, Martin-Estebane M, Pipi E, Barkwill LM, Gonzalez-Rivera I, Buchanan F, Prescott AR, Faust D, Fox S, et al.IL-34 antibody (mouse monoclonal IgG2A (v1.1 manufactured by Genscript, (24, 25)), rat monoclonal IgG2A (MAB5195, R&D Systems) and sheep polyclonal IgG (AF5195, R&D Systems) and 10 μL IL-34 stimulus (R&D systems,

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IL-34 Antibody

IL-34 Antibody

IL-34 Antibody

IL-34 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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IL-34 Antibody from R&D Systems, a Bio-Techne Brand

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