Gephyrin Antibody 147 111 from Synaptic Systems GmbH

Product Specs
ItemGephyrin Antibody
CompanySynaptic Systems GmbH
Price $435.00Supplier Page View Company Product Page
Catalog Number147 111
Quantity100 µg
ApplicationsWB, IP, ICC, IHC-Fr
Formatlyophilized
TargetGephyrin
Reactivityhuman, rat, mouse, zebrafish
IsotypeIgG1
Hostmouse
Clone3B11
ImmunogenRecombinant protein corresponding to AA 307 to 735 from rat Gephyrin
Antibody TypePrimary antibody
Clonalitymonoclonal
Cell Line3B11
ValidationKO

Questions and Answers

What applications has the Gephyrin antibody been used for in scientific research?

The Gephyrin antibody has been shown to work in various applications including Western Blotting, Immunocytochemistry, Immunohistochemistry, and Immunoprecipitation, as evidenced by its use in multiple studies to analyze gephyrin's role in synaptic function and plasticity.

Can this antibody be used to study gephyrin interactions in GABAergic synapses?

Yes, the Gephyrin antibody has been utilized to investigate interactions at GABAergic synapses, particularly in studies examining the role of gephyrin in the organization of GABA receptors and its modulation by other proteins, such as Neuroligin-2.

Is the Gephyrin antibody effective in knockout models?

The Gephyrin antibody has been validated for use in knockout models, as indicated by its application in studies involving genetically engineered mice, which helps elucidate the functional consequences of gephyrin loss in synaptic transmission.

What species can this antibody react with, and how does that impact its utility in research?

The Gephyrin antibody is reactive with multiple species, including mouse, rat, human, and zebrafish. This broad reactivity allows researchers to use it in comparative studies across different model organisms, enhancing its utility in understanding gephyrin's role in various biological contexts.

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) Neuroligin-2-dependent adhesion defines a molecular checkpoint for inhibitory synaptic plasticityJ NeurosciApril 22, 2026Anna Lech, Grzegorz Wiera, Jerzy W. Mozrzymasshaker. The following primary antibodies were used: mouse anti-gephyrin (Synaptic Systems, catalog #147 111; 1:800), rabbit anti-vesicular GABA transporter (vGAT; Synaptic Systems, catalog #131 002; 1:500), mouse

(2) The atypical adhesion GPCR ADGRA1 controls hippocampal inhibitory circuit functionCell ReportsApril 9, 2026Baris Tosun, Kelly Honkanen, Elizabeth Orput, Swarada Kulkarni, Duy Lan Huong Huong Bui, Richard C. Sando(Synaptic Systems, Cat#102002, 1:500 IHC), anti-Gephyrin mouse (1:2,000 ICC, Synaptic Systems, Cat#147111) anti-Parvalbumin rabbit (SWANT, Cat#PV27a, 1:2,000 IHC), anti-Synaptotagmin-2 (Synaptic Systems, Cat#105225,1:500

(3) Infant gut microbiomes contribute to metabolic states that impact brain functionbioRxivMarch 13, 2026Firas S. Midani, Do-Hun Lee, Younghye Moon, Maggie Seale, Thomas D. Horvath, A. Kyle Ardis, José Cantú, Emavieve Coles, Jason D. Pizzini, Duolong Zhu, et al.for 1 h at RT in the dark. The following antibodies were used: mouse anti-Gephyrin (Synaptic Systems, 147111; 1:500), mouse anti-PSD-95 (Antibodies Inc., 75–028; 1:500), rabbit anti-5-HT (ImmunoStar, 20080; 1:5000),

(4) Neuroligin-2-Dependent Adhesion Defines a Molecular Checkpoint for Inhibitory Synaptic PlasticityJ NeurosciMarch 9, 2026Anna Lech, Grzegorz Wiera, Jerzy W. Mozrzymasshaker. The following primary antibodies were used: mouse anti-gephyrin (Synaptic Systems, catalog #147 111; 1:800), rabbit anti-vesicular GABA transporter (vGAT; Synaptic Systems, catalog #131 002; 1:500), mouse

(5) Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutationScience AdvancesFebruary 20, 2026Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A. Deming, Yue Shu, et al.(Thermo Fisher Scientific, MA5-15854), anti-VGAT (Synaptic System, 131002), and anti-Gephyrin (Synaptic System, 147111). Confocal images were acquired using a Z-stack laser scanning confocal fluorescence microscope (LSM900;

(6) Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordinationExperimental & Molecular MedicineFebruary 18, 2026Jea Kwon, Sunpil Kim, Junsung Woo, Keiko Tanaka-Yamamoto, Oliver James, Erik De Schutter, Sungho Hong, C. Justin Leeanti-GABRα1 (06-868, Sigma), rabbit anti-VGAT (131 003, Synaptic Systems) and mouse anti-gephyrin (147 111, Synaptic Systems). Secondary antibodies were Alexa Fluor 488-conjugated anti-rabbit and Alexa Fluor

(7) Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic ProteinsAdvanced ScienceDecember 16, 2025Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiaoanti‐GAPDH (1:5000, Cell Signaling Technology, 5174), mouse anti‐gephyrin (1:4000, Synaptic Systems, 147 111), rabbit anti‐GFP (1:1000; Invitrogen A‐11122), rabbit anti‐mGluR1 (1:500, Cell Signaling Technology,

(8) Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technologyCommunications BiologyNovember 17, 2025Lilach Elbaum-Mendelson, Weixiang Yuan, Johannes P.-H. Seiler, Nadia Blom, Ya-Chien Chan, Ali Hyder Baig, Nils Brose, Simon Rumpel, Noam E. ZivN3702-AF647-L; 1:200), or exposed to a mouse anti gephyrin primary antibody (Synaptic Systems anti gephyrin #147 111 or #147 011; 1:500 and 1:1000, respectively) overnight at 4 °C, followed by washing with PBS and labeling

(9) Neuroanatomical characterization of the cell adhesion molecule IgSF9b reveals localization to inhibitory and excitatory synapses in the mouse limbic systemJournal of molecular medicine (Berlin, Germany)November 1, 2025Rotondo F, Ali H, Maichle M, Schmeisser MJ, Brose N, Krueger-Burg D.(RRID:AB_2619815, Synaptic Systems 129205, 1:500), mouse anti-Gephyrin (RRID:AB_2619837, Synaptic Systems 147111, 1:500), rabbit anti-IgSF9b (Atlas Antibodies Cat# HPA010802, RRID:AB_1079194, 1:200; 0.12 µg/µl, only

(10) Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylationMolecular psychiatryOctober 31, 2025Jung H, Kim B, Jang G, Lee H, Kim Y, Kim H, Lee HJ, Kim D, Yang Y, Jeong WC, et al.(Synaptic Systems; Cat# 261 003; RRID: AB_26199777), mouse monoclonal anti-gephyrin (Synaptic Systems; Cat# 147 111; RRID: AB_887719), rabbit polyclonal anti-GABAA receptor γ2 (Synaptic Systems; Cat# 224 003; RRID: AB_2263066),

(11) Slit2/Robo1 signaling constrains image stabilization responses to preserve ethologically favorable directional asymmetryCurrent BiologyOctober 6, 2025James K. Kiraly, Annika Balraj, Paige Leary, Zihao You, Scott C. Harris, Jeanette D. Hyer, Felice A. Dunn, Alex L. Kolodkinprotein,Neuromab,Cat # 75-028; RRID: AB_2292909 Mouse monoclonal anti-Gephyrin,Synaptic Systems,Cat # 147111; RRID: AB_887719 Rabbit monoclonal anti-cFos,Cell Signaling Technology,Cat # 2250; RRID: AB_2247211 ,, Bacterial

(12) Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balanceeLifeOctober 2, 2025Xue Chen, Deng Pan, Jia-Jia Liu, Yanrui Yangsources: rabbit anti-endophilin A1 (159 002, Synaptic Systems GmbH, Germany), mouse anti-Gephyrin (147 111, Synaptic Systems), guinea pig anti-gephyrin (147 318, Synaptic Systems), mouse anti-neuroligin 2 (129 511

(13) Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balanceElifeOctober 2, 2025Xue Chen, Deng Pan, Jia-Jia Liu, Yanrui Yangsources: rabbit anti-endophilin A1 (159 002, Synaptic Systems GmbH, Germany), mouse anti-Gephyrin (147 111, Synaptic Systems), guinea pig anti-gephyrin (147 318, Synaptic Systems), mouse anti-neuroligin 2 (129 511

(14) Regulation of hippocampal excitatory synapse development by the adhesion G-protein coupled receptor brain-specific angiogenesis inhibitor 2 (BAI2/ADGRB2)Molecular and Cellular NeuroscienceSeptember 1, 2025Christina M. Meyer, Olga Vafaeva, Henry Low, David J. Speca, Elva Díazμg/mL,N/A PSD95,NeuroMab,K28/43,AB_2292909,1 μg/mL,4 μg/mL vGLUT1,Millipore,AB5905,AB_2301751,1 μg/mL,4 μg/mL Gephyrin,Synaptic Systems,147 111,AB_887719,1 μg/mL,4 μg/mL vGAT,NeuroMab,L118/80,AB_2629422,0.55 μg/mL,N/A BAI2/AD GRB2,R&D Systems,MAB9338,,5

(15) Altered GABAergic Homeostasis in the Striatum of Dopamine Transporter Knockout RatsCurrent NeuropharmacologyAugust 1, 2025Giorgia Targa, Beatrice Rizzi, Francesca Mottarlini, Raul R. Gainetdinov, Damiana Leo, Fabio Fumagalli, Lucia Caffino(1:1000, Synaptic System, cod. 129511, RRID: AB_2619813), anti Gephyrin (1:1000, Synaptic System, cod. 147111, RRID: AB_2619837), anti Reelin (1:1000, Abcam, cod. ab78540, RRID: AB_1603148), anti Calbindin (1:1000,

(16) Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAAR subsynaptic reorganizationFront Cell NeurosciJuly 4, 2025Caitlyn A. Chapman, Nadya Povysheva, Tyler B. Tarr, Jessica L. Nuwer, Stephen D. Meriney, Jon W. Johnson, Tija C. Jacobγ2,Rabbit,Synaptic Systems,Cat# 224 003 RRID:AB_2263066,"1/2,000",PLA,6 Gephyrin 3B11,Mouse,Synaptic Systems,Cat# 147 111 RRID:AB_887719,1/500,DNA-PAINT,2 Gephyrin 3B11,Mouse,Synaptic Systems,Cat# 147 111 RRID:AB_887719,"1/1,000",Western blot

(17) Coordinated dynamics of excitatory and inhibitory synapse assemblybioRxivJune 3, 2025Krassimira Garbett, James Allen, Richard C. Sandoanti-GABARα1 rabbit (Synaptic Systems, cat# 224203, 1:1,000), anti-Gephyrin mouse (Synaptic Systems cat# 147111, 1:2,000), anti-vGLUT1 (Millipore cat# AB5905, 1:1,000), corresponding fluorescently-conjugated goat

(18) Altered GABAergic Homeostasis in the Striatum of Dopamine Transporter Knockout RatsCurr NeuropharmacolApril 18, 2025Giorgia Targa, Beatrice Rizzi, Francesca Mottarlini, Raul R. Gainetdinov, Damiana Leo, Fabio Fumagalli, Lucia Caffino(1:1000, Synaptic System, cod. 129511, RRID: AB_2619813), anti Gephyrin (1:1000, Synaptic System, cod. 147111, RRID: AB_2619837), anti Reelin (1:1000, Abcam, cod. ab78540, RRID: AB_1603148), anti Calbindin (1:1000,

(19) Regulation of hippocampal excitatory synapse development by the adhesion G-protein coupled receptor Brain-specific angiogenesis inhibitor 2 (BAI2/ADGRB2)bioRxiv : the preprint server for biologyFebruary 3, 2025Meyer CM, Vafaeva O, Low H, Speca DJ, Díaz E.μg/mL,N/A PSD95,NeuroMab,K28/43,AB_2292909,1 μg/mL,4 μg/mL vGLUTl,Millipore,AB5905,AB_2301751,1 μg/mL,4 μg/mL Gephyrin,Synaptic Systems,147 111,AB_887719,1 μg/mL,4 μg/mL vGAT,NeuroMab,L118/80,AB_2629422,0.55 μg/mL,N/A BAI2,R&D Systems,MAB9338,,5

(20) Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampusImmunityJanuary 14, 2025Matera A, Compagnion AC, Pedicone C, Kotah JM, Ivanov A, Monsorno K, Labouèbe G, Leggio L, Pereira-Iglesias M, Beule D, et al.

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Gephyrin Antibody

Gephyrin Antibody

Gephyrin Antibody from Synaptic Systems GmbH

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Questions and Answers

Synaptic Systems GmbH

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Gephyrin Antibody from Synaptic Systems GmbH

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