Synapsin1/2 antibody 106 004 from Synaptic Systems GmbH

Product Specs
ItemSynapsin1/2 antibody
CompanySynaptic Systems GmbH
Price $400.00Supplier Page View Company Product Page
Catalog Number106 004
Quantity100 µl
ApplicationsWB, ICC, IHC, IHC-P
Formatantiserum
Reactivityhuman, rat, mouse, hamster, cow, zebrafish
TargetSynapsin1/2
HostGuinea pig
Clonalitypolyclonal
ValidationKO
ImmunogenSynthetic peptide corresponding to AA 2 to 28 from rat Synapsin1

Questions and Answers

Can this antibody be used for immunohistochemistry in mouse brain tissue?

Yes, the Synapsin1/2 antibody has been shown to work effectively in immunohistochemistry applications for mouse brain tissue, as evidenced by its use in various studies, including those that investigate synaptic structures and functions.

What species can this antibody react with in experiments?

The Synapsin1/2 antibody is reactive with several species, including mouse, rat, human, bovine, hamster, and zebrafish, making it versatile for studies involving different model organisms.

Has this antibody been utilized in any specific research contexts?

Yes, the Synapsin1/2 antibody has been cited in numerous scientific articles, including studies focused on synaptic plasticity and neuronal development, such as the investigation of synaptic connectivity and the role of synapsin in neurotransmitter release.

What is the recommended dilution for using this antibody in immunocytochemistry?

The recommended dilution for the Synapsin1/2 antibody in immunocytochemistry is typically around 1:500, as indicated in various protocols and studies that have successfully employed this antibody for visualizing synaptic markers.

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) Synaptophysin autoantibodies mediate synaptic dysfunction in cerebellar ataxiaCell Reports MedicineJune 16, 2026Samantha Ho, Hoi Kiu Wong, Dorina Shqau, Stephan Winklmeier, Marcus Grobe-Einsler, Kevin Rostasy, Tania Kümpfel, Franziska S. Thaler, Lior Brimberg, Marc A. Schneider, et al.ATPase,Invitrogen,CAT#: MA5-32184; RRID: AB_2809472 Guinea pig anti-Synapsin 1,Synaptic Systems,CAT#: 106 004; RRID: AB_1106784 Mouse anti-SYP,BioTechne,CAT#: MAB5555; RRID: AB_3658464 Mouse anti-SYP antibody,Dako,CAT#:

(2) 1 Hz Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Epilepsy by Suppressing Interferon-γ Signaling-Dependent Microglial Synaptic Phagocytosis in MiceCNS Neurosci TherJune 13, 2026Donghui Lin, Duan Wang, Nong XiaoCHN), anti‐GFAP (AB5541, 1:1000, Millipore, USA), anti‐CD68 (ab955, 1:200, Abcam, UK), antisynapsin1/2 (106004, 1:1000, Synaptic systems, GER), anti‐APOE (sc‐390925, 1:400, Santa Cruz Biotechnology, USA), anti‐IFIT3

(3) Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastasesNature CommunicationsMay 28, 2026Morgan S. Fox, Jenny A. Jaramillo-Gómez, R. Alejandro Marquez-Ortiz, Karen L. F. Alvarez-Eraso, Maria J. Contreras-Zárate, Trinh C. Pham, Elaina N. Barela, Stella N. Koliavas, Peter Kabos, Natalie J. Serkova, et al.ab59194, 1:400), NCAM1 (R&D AF2408, 1:200), PanCK (DAKO M0821, 1:100), Synapsin1/2 (Synaptic Systems 106004, 1:1000), PSD95 (Invitrogen MA1-045, 1:500), and pERK (Cell Signaling 9101S, 1:200) were incubated for

(4) Disruption of the LRRK2 substrate RAB12 facilitates neurotransmission and causes hyperactivity in micenpj Parkinson's DiseaseApril 24, 2026Xingjian Li, Yuanxin Chen, Huaixing Wang, Xue Zhang, Noah Guy Lewis Guiberson, Xianting Li, Jacqueline Burré, Junmin Peng, Hui Zhang, Zhenyu Yueincubated overnight at 4 °C with primary antibodies: guinea pig anti-synapsin1/2 (Synaptic Systems, #106004, 1:1000), and goat anti-mCherry (SICGEN, #AB0040-200, 1:1000). Cells were washed three times with PBST

(5) Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na+ channel dynamics in human neuronsMolecular PsychiatryApril 15, 2026Lei Cui, Erkin Kurganov, Derek Hawes, Philipp Hornauer, Raozhou Lin, Yining Wang, Andreas Hierlemann, Morgan Sheng, Ralda Nehme, Jen Q. Pan(1:2000, Abcam, ab5392), PSD-95 (1:100, BioLegend, 810401), Synapsin I/II (1:1000, Synaptic Systems, 106004), Anti-Sodium Channel (Pan-Nav, 1:1000, Sigma-Aldrich, S8809), Nav1.2 (1:200, Alomone Labs, ASC-002).

(6) Bindarit attenuates brain injury and neuroinflammation in status epilepticus by disrupting C3/C3aR signaling and modulating microglia-astrocyte interactionsCell Communication and SignalingApril 13, 2026Jiancong Chen, Yanhong Hu, Jiaxin Xie, Haiping Zhou, Tingting Yang, Mingjia Yu, Jingwen Wu, Suyue Pan, Kaibin Huang(sc271430, Santa Cruz, CA, USA), anti-CD68 (MCA1957T, Bio-Rad, California, USA), anti-Synapsin1/2 (SYP; 106004, Synaptic Systems, Goettingen, Germany), anti-C3 (sc28294, Santa Cruz), anti-C3aR (HM1123, Hycult, Wayne,

(7) Multi-omic analysis of guided and unguided forebrain organoids reveals differences in cellular composition and metabolic profilesCell Reports MethodsFebruary 23, 2026Marie Sejberg Øhlenschlæger, Pia Jensen, Jesper Foged Havelund, Sissel Ida Schmidt, Fadumo Abdullahi Mohamed, Magdalena Sutcliffe, Sofie Blomberg Elmkvist, Lucrezia Criscuolo, Steven W. Wingett, Ilaria Chiaradia, et al.anti-SATB2,Abcam,"Cat# ab34735, RRID: AB_2301417" Guinea pig polyclonal anti-SYN1/2,Synaptic Systems,"Cat# 106 004, RRID: AB_1106784" Rabbit recombinant monoclonal anti-TBR1,Abcam,"Cat# ab183032, RRID: AB_2936859" Rabbit

(8) Nervous System-on-Chip: Innovative Microfluidic Platform to Compartmentalize hiPSC-Derived Neural NetworksMicromachines (Basel)February 1, 2026Rahman Sabahi-Kaviani, Antigoni Gogolou, Celine Souilhol, Mark van der Kroeg, Steven A. Kushner, Femke M. S. de Vrij, Anestis Tsakiridis, Regina Luttge(Zeiss, Oberkochen, Germany). The following primary antibodies were used: Synapsin 1/2 (Synaptic Systems 106004, Göttingen, Germany, 1:200); NF200 (Sigma-Aldrich 083M4833 1:200); MAP2 (Synaptic Systems 188004, 1:200);

(9) Early synaptic pathology is associated with small tau aggregates in Alzheimer’s diseaseActa NeuropathologicaJanuary 23, 2026Emre Fertan, Shekhar Kedia, George Nolan, Georg Meisl, Matthew W. Cotton, Karin H. Müller, Ziwei Zhang, Leila Muresan, Annelies Quaegebeur, Maria Grazia Spillantini, et al.immunofluorescence assay was performed to visualise AT8 + tau and synapsin (Synaptic Systems, Cat. 106–004) as the pre-synaptic marker. Slide-mounted tissue sections were post-fixed with 4% formaldehyde and

(10) Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic developmentbioRxivJanuary 17, 2026Jayne Aiken, Carris Borland, Nicolas Marotta, Benjamin L. Prosser, Erika L. F. Holzbauranti-NF-H; BioLegend, 801601; 1:1000), Synapsin I/II (guinea pig anti-Synapsin I/II; Synaptic Systems, 106–004; 1:1000), PSD-95 (rabbit anti-PSD-95; Synaptic Systems, 124–008; 1:500), MAP2 (mouse anti-MAP2; EMD Millipore

(11) Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivityeLifeOctober 20, 2025Karagulyan N, Überegger M, Qi Y, Babai N, Hofer F, Johnson Chacko L, Wang F, Luque M, Glueckert R, Schrott-Fischer A, et al.BioSciences), guinea pig anti-RibeyeA (1:500, 192104, Synaptic Systems), guinea pig anti-Synapsin1/2 (1:500, 106004, Synaptic Systems), guinea pig anti-Vglut3 (1:500, 135204, Synaptic Systems), chicken anti-parvalbumin

(12) Synaptojanin-1 supports VPS35-dependent trafficking of dopamine D2 autoreceptors at presynaptic terminalsResearch SquareOctober 16, 2025Pingyue Kumar, Nirmal Khezerlou, Justin Khezerlou, Justin Caiola, Hanna Caiola, Ulrik Gether, Ping-Yue Zhangantibodies were used in this study: polyclonal anti-guinea pig synapsin I/II (Synaptic System, Cat. #106004, 1:500), polyclonal anti-goat VPS35 (Novus Biologicals, Cat. #NB100–1397; 1:500), rabbit anti-TH (Novus Biologicals

(13) Distinct Filament Conformation for Receptor-Bound Amyloid-ß from Alzheimer’s Disease BrainbioRxivOctober 16, 2025Mikhail A. Kostylev, Carmen Butan, Graham P. Roseman, Yangyi Liu, Pallavi Gopal, Stephen M. Strittmattersolution (1% horse serum in PBST) containing 1:500 guinea pig anti-Synapsin 1/2 (Synaptic Systems # 106004), 1:500 rabbit anti-Homer1b/c (Synaptic Systems #160022), and 1:3000 chicken anti-MAP2 (Novus Biologics

(14) Mechanodynamic brain on chip for studying human stem cell derived neuronal networksSci RepAugust 13, 2025Gulden Akcay, Regina Luttgepolyclonal, Synaptic systems, 160 006, 1:500; Synapsin 1/2, Guinea pig polyclonal, Synaptic systems, 106 004, 1:1000) were diluted in 1% blocking buffer were applied to the cells and incubated overnight at 4\documentclass[12pt]{minimal}

(15) The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal functionbioRxiv : the preprint server for biologyJuly 29, 2025Williams CA, Rose SE, Stamenkovic V, Smith SEP, Young JE.at 4°C overnight. HOMER1 (Synaptic Systems cat. #160003 1:250), SYNAPSIN1/2 (Synaptic Systems cat. #106004 1:500), GLUR1 (Millipore cat. # MAB2263 1:500), GLUR2 (ProteinTech cat. #11994–1-AP 1:500), MAP2 (Abcam

(16) Triglycerides are an important fuel reserve for synapse function in the brainNat MetabJuly 1, 2025Mukesh Kumar, Yumei Wu, Justin Knapp, Catherine L. Pontius, Daehun Park, Rose E. Witte, Rachel McAllister, Kallol Gupta, Kartik N. Rajagopalan, Pietro De Camilli, et al.for immunolabelling: DDHD2 (Proteintech, 25203-1-AP, RRID:AB_2879957), synapsin (Synaptic Systems, 106004, RRID:AB_1106784), TOMM20 (Sigma-Aldrich, WH0009804M1, RRID:AB_1843992), β-III tubulin (R&D Systems,

(17) Inflammasome signaling in astrocytes modulates hippocampal plasticityImmunityJune 10, 2025Kristine E. Zengeler, Ava Hollis, Tyler C.J. Deutsch, Joshua D. Samuels, Hannah Ennerfelt, Katelyn A. Moore, Eric J. Steacy, Vikram Sabapathy, Rahul Sharma, Manoj K. Patel, et al.AnaSpec, 1:300), S100β (15146–1-AP, Proteintech, 1:500), SOX9 (EPR14335–78, Abcam, 1:500), Synapsin1/2 (106 004, Synaptic Systems, 1:1000), Synaptophysin (ab32594, Abcam, 1:1000), Synaptophysin (ab16659, Abcam, 1:300),

(18) α-Synuclein interacts directly with AP2 and regulates its binding to synaptic membranesJournal of Biological ChemistryApril 9, 2025Karina J. Vargas, Jaqulin N. Wallace, Ian Mooney, David J. Owen, Jennifer R. Morganα-synuclein (clone D37A6, rabbit polyclonal, Cell Signaling; 1:500) and synapsin1/2 (Synaptic systems, SySy 106 004; 1:1000). We used Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 for the

(19) Optimization of Transcription Factor-Driven Neuronal Differentiation from Human Induced Pluripotent Stem Cells for Disease Modelling and Drug ScreeningStem cell reviews and reportsApril 1, 2025Servetti M, Caramia M, Parodi G, Loiacono F, Nano E, Biddau G, Ferrando L, Morinelli L, Valente P, Martinoia S, et al.Synaptic Systems; 188003; 1:200), SMI312 (Biolegend; 837904; 1:200), Synapsin 1/2 (Synaptic Systems; 106004; 1:100), Synaptophysin (Millipore; MAB5258; 1:100), Tubulin beta III (Millipore; MAB1637; 1:200), NeuN

(20) The Shab family potassium channels are highly enriched at the presynaptic terminals of human neuronsThe Journal of biological chemistryMarch 1, 2025Benner O, Karr CH, Quintero-Gonzalez A, Tamkun MM, Chanda S.catalog no.: 106002), guinea pig anti-Synapsin1/2 (1:1000 dilution; Synaptic Systems, catalog no.: 106004), mouse anti-Tuj1 or β-tubulin III (1:500 dilution; BioLegend, catalog no.: 801202), mouse anti-Oct3/4

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8/8/2016This Anti Synapsin 1/2 Is Good Antibody Timur MavlyutovAim of this research was to detect intensity of synapsin 1/2 protein in active zones of substance P positive neurons. This anti-synapsin antibody was selected because company promised their high ... Read Review

Synapsin1/2 antibody

Synapsin1/2 antibody

Synapsin1/2 antibody

Synapsin1/2 antibody

Synapsin1/2 antibody

Synapsin1/2 antibody from Synaptic Systems GmbH

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Synaptic Systems GmbH

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Synapsin1/2 antibody from Synaptic Systems GmbH

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