Gephyrin Antibody 147 011 from Synaptic Systems GmbH

Product Specs
ItemGephyrin Antibody
CompanySynaptic Systems GmbH
Price $440.00Supplier Page View Company Product Page
Catalog Number147 011
Quantity100 µg
ApplicationsICC, IHC
Hostmouse
Formatlyophilized
IsotypeIgG1
TargetGephyrin
Reactivityhuman, rat, mouse, pig, goldfish, zebrafish, chicken
Clonalitymonoclonal
Cell LinemAb7a
ValidationKO
ClonemAb7a
ImmunogenNative Protein corresponding to AA 1 to 768 from rat Gephyrin
Antibody TypePrimary antibody

Questions and Answers

Can this Gephyrin antibody be used for immunohistochemistry in mouse brain tissue?

Yes, the Gephyrin antibody has been successfully used for immunohistochemistry in mouse brain tissue, as indicated in various studies, including those that utilized it at a dilution of 1:500 for staining purposes.

Is the Gephyrin antibody effective for studying synaptic plasticity in cerebellar Purkinje cells?

The Gephyrin antibody has been shown to be effective in studies investigating synaptic plasticity, particularly in cerebellar Purkinje cells, where it was used to analyze GABAergic synapses and their modulation during inhibitory synaptic plasticity.

What species can this Gephyrin antibody react with in experimental applications?

The Gephyrin antibody is reactive with multiple species, including mouse, rat, human, chicken, zebrafish, and porcine, making it versatile for various experimental models.

Has this antibody been cited in research related to astrocytic control of synapses?

Yes, the Gephyrin antibody has been cited in research exploring the role of astrocytes in synaptic function, particularly in studies that examine how astrocytic proteins interact with gephyrin at inhibitory synapses, influencing synaptic density and function.

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) Bazedoxifene reverses sexually dimorphic autistic-like abnormalities in biallelic MDGA1-mutant miceEMBO Molecular MedicineMarch 20, 2026Seungjoon Kim, Hyeonho Kim, Javier Porta Pelayo, Sara Alvarez, Gyubin Jang, Jinhu Kim, Byeongchan Kim, Victoria M Hoelscher, Beatriz Calleja-Pérez, Hyunsu Jung, et al.(Millipore; Cat# AB5905; RRID: AB_2301751); mouse monoclonal anti-gephyrin (Synaptic Systems; Cat# 147 011; RRID: AB_887719); rabbit polyclonal anti-VGAT (Synaptic Systems; Cat# 131 003; RRID: AB_887869); rabbit

(2) Localization of Puncta Adherentia Junctions at GABAergic Synapses on Parvalbumin‐Positive GABAergic Inhibitory Neurons in the Mouse HippocampusJournal of Comparative NeurologyMarch 19, 2026Kimitaka Katanazaka, Hajime Shiotani, Muneaki Miyata, Takeshi Kameyama, Shin Kedashiro, Ryouhei Komaki, Shota Nishii, Yutaro Kashiwagi, Yuka Sato, Shigeo Okabe, et al.cultured mouse hippocampal neurons (Heldt et al. 2012). Mouse anti‐gephyrin mAb (Synaptic Systems, Cat# 147 011, RRID: AB_887717) was raised against a native protein corresponding to rat gephyrin (amino acids 1–768).

(3) Ischemic stroke triggers brain-wide synaptic remodeling within four hoursPLoS BiolMarch 2, 2026Huanhuan Chen, Ye Wei, Luminiţa Ruje, Fusheng Du, Zhendong Feng, Qi Wan, Mikhail Spivakov, Oleg O. Glebov,Synaptic systems,160002 BSN,Abcam,ab82958 GABRA1,Synaptic systems,224203 GluA2,Sigma-Aldrich,AB1768-I Gephyrin,Synaptic systems,147011 vGlut1,Synaptic systems,135302 Cav2.1,Synaptic systems,152203 Synaptotagmin1,Synaptic systems,105311 GluN1,Alomone,AGC001 GluN2B,ZenBio,310326 Goat

(4) Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapseseLifeFebruary 16, 2026Serena Camuso, Yana Vella, Souad Youjil Youjil Abadi, Clémence Mille, Bert Brône, Christian G Spechtwere labelled with primary antibodies against gephyrin (mAb7a mouse monoclonal, Synaptic Systems, #147011, RRID:AB_2810215, 1:1000 dilution) and mEos protein (AF647-conjugated FluoTag-X2, NanoTag Biotechnologies;

(5) Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like BehaviorsAdvanced ScienceFebruary 4, 2026Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, et al.(ab216463, 1:1,000; Abcam), rabbit anti‐PSD95 (#51‐6900, 1:1000; Invitrogen), mouse anti‐Gephyrin (#147011, 1:1000; Synaptic systems, Göttingen, Germany), VGAT (#131006, 1:1,000; Synaptic systems), mouse anti‐PDGFRa

(6) In utero exposure to anti-Caspr2 antibody disrupts parvalbumin interneuron function in the hippocampusBrain, Behavior, and ImmunityFebruary 1, 2026Ciara Bagnall-Moreau, Joshua J. Strohl, Benjamin Spielman, Christian Cruz, Patricio Huerta, Lior Brimberg(mouse, MAB1572, Millipore), anti-parvalbumin (rabbit, 195–002, Synaptic Systems) anti-gephyrin (mouse, 147011, Synaptic Systems) anti-cleaved caspase 3 (rabbit, 9661S, Cell signaling technologies), anti-vGLUT1

(7) The Neurexin1β Histidine-Rich Domain Is Involved in Excitatory Presynaptic Organization and Short-Term PlasticityeNeuroJanuary 26, 2026Benjamin Feller, Mai Inagaki, Manni Wang, Annika Sivak, Nicolas Chofflet, Hideto TakahashiIgG; catalog #131 003, RRID:AB_887869, Synaptic Systems) and Gephyrin (1:500; mouse IgG1; catalog #147011, RRID: AB_2810215, Synaptic Systems). An antibody against MAP2 was also applied to stain the dendrites.

(8) The Highly Localized Interaction between Neurofascin-186 and Gliomedin Promotes Subcellular Innervation by the Chandelier CellJ NeurosciJanuary 14, 2026Yasufumi Hayano, Yugo Ishino, Manzoor A. Bhat, Elior Peles, Hiroki Taniguchi1:1,000 (Synaptic Systems, catalog #131004), and mouse anti-Gephyrin 1:500 (Synaptic Systems, catalog #147011). After three washing steps each for 30 min in PBS with 0.03% Triton X-100 (PBST), the slices were incubated

(9) Paralogs of Slitrk cell adhesion molecules configure excitatory synapse specificity via distinct cellular mechanismsPLoS BiolDecember 18, 2025Dongwook Kim, Byeongchan Kim, Jinhu Kim, Na-Young Seo, Hyeonho Kim, Kyung Ah Han, Jubeen Yoon, Christian P. Macks, Joris de Wit, Chang Ho Sohn, et al.BioLegend; Cat #MMS-5182; RRID: AB_2564750); mouse polyclonal anti-gephyrin (Synaptic Systems; Cat #147 011; RRID: AB_887717); rabbit monoclonal anti-TrkB (clone 80E3; Cell Signaling; Cat #4603; RRID: AB_2155125);

(10) Microglia drive synaptic and functional connectivity deficits in the Ts65Dn mouse model of Down syndrome by affecting inhibitionActa Neuropathologica CommunicationsDecember 17, 2025Alexia Tiberi, Elena Montagni, Giulia Borgonovo, Eléa Coulomb, Laura Restani, Anna Letizia Allegra Mascaro, Simona Capsoni, Antonino Cattaneorabbit anti-vGlut1 1:1000 (Synaptic System; #135 302), mouse anti-Gephyrin 1:1000 (Synaptic System; #147 011), rabbit anti-vGAT 1:1000 (Synaptic System; #131 002). Images corresponding to neuronal dendrites and

(11) Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesisbioRxivDecember 16, 2025Kristina Sakers, Juan J. Ramirez, Nimrod Elazar, Leykashree Nagendren, Erik Soderblom, Cagla ErogluPSD95 (1:300, rabbit, Invitrogen 51–6900, RRID:AB_2533914), Gephyrin (1:500, mouse, Synaptic Systems 147011, RRID:AB_2810215), RFP (1:1000, chicken, Rockland 600–901-379, RRID:AB_10704808, used for synaptic staining),

(12) Necl-4/CADM4 regulates GABAergic synaptic strength on GABAergic inhibitory neurons via ErbB4 activation and prevents neuronal impairmentsMolecular neurobiologyDecember 1, 2025Komaki R, Shiotani H, Kuriu T, Kameyama T, Miyata M, Kedashiro S, Katanazaka K, Nishii S, Chihara N, Matsumoto R, et al.anti-GAT-3 pAb (FRONTIER INSTITUTE, GAT3(590–627)-Rb-Af440), mouse anti-gephyrin mAb (Synaptic Systems, 147 011), guinea pig anti-gephyrin mAb (Synaptic Systems, 147 318), chicken anti-GFAP pAb (Abcam, ab134436),

(13) Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse ModelAdvanced ScienceNovember 27, 2025Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, et al.PA5‐85759), mouse anti‐PV (1: 1000; Millipore, P3088), mouse anti‐gephyrin (1: 500; Synaptic Systems, 147 011), guinea pig anti‐Bassoon (1: 500; Synaptic Systems, 141 318), rabbit anti‐VGAT (1: 500; Millipore,

(14) Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technologyCommunications BiologyNovember 17, 2025Lilach Elbaum-Mendelson, Weixiang Yuan, Johannes P.-H. Seiler, Nadia Blom, Ya-Chien Chan, Ali Hyder Baig, Nils Brose, Simon Rumpel, Noam E. Ziv1:200), or exposed to a mouse anti gephyrin primary antibody (Synaptic Systems anti gephyrin #147 111 or #147 011; 1:500 and 1:1000, respectively) overnight at 4 °C, followed by washing with PBS and labeling with a

(15) Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylationMolecular psychiatryOctober 31, 2025Jung H, Kim B, Jang G, Lee H, Kim Y, Kim H, Lee HJ, Kim D, Yang Y, Jeong WC, et al.Cat# 147 021; RRID: AB_2232546), mouse monoclonal anti-gephyrin (Clone mAb7a; Synaptic Systems; Cat# 147 011; RRID: AB_887717), rabbit polyclonal anti-Akt (Cell Signaling; Cat# 9272; RRID: AB_32982), rabbit polyclonal

(16) Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defectsNeuronOctober 1, 2025Ryan M. Walsh, Gregg W. Crabtree, Kriti Kalpana, Luz Jubierre, So Yeon Koo, Gabriele Ciceri, Joseph A. Gogos, Ilya Kruglikov, Lorenz StuderRRID:AB_10000343" Guinea Pig anti SYN1,Synaptic Systems,"106 104, RRID:AB_2721082" Mouse anti GPHN,Synaptic Systems,"147 011, RRID:AB_887717" Chicken anti GFP,Abcam,"ab13970, RRID:AB_300798" Rabbit anti mCherry,Rockland,"600–401-P16,

(17) Prefrontal cortex astrocytes modulate distinct neuronal populations to control anxiety-like behaviorNat CommunAugust 21, 2025Eunyoung Kim, Hairuo Du, Yanqi Tan, Brandon L. Brown, Yaowen Chang, Blanca Díaz-Castro, Jonathan V. Sweedler, Xinzhu Yu(1:1000, AB52488; Millipore), mouse anti-NeuN (1:1000, MAB377; Millipore), mouse anti-GPHN (1:250, 147011; Synaptic systems), mouse anti-PSD95 (1:250, MA1-046; Thermo Fisher Scientific), mouse anti-ATPB (1:1000,

(18) Hide-and-Seek genome editing reveals that Gephyrin is required for axo-axonic synapse assemblyProceedings of the National Academy of Sciences of the United States of AmericaAugust 12, 2025Ogawa Y, Nguyen DVM, Ogawa A, Rasband MN.Novus Biologicals Cat#NB120-11427, RRID:AB_791498, 1:500), mouse monoclonal anti-Gephyrin (Synaptic Systems Cat#147011, RRID:AB_2810215, 1:500), and mouse monoclonal anti-Nlgn2 (UC Davis/NIH NeuroMab Facility clone L107/39,

(19) DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46Neurobiology of diseaseAugust 1, 2025Cerullo MS, Canevari C, Marte A, Bacq A, De Fusco A, Maletic M, Baulac S, Benfenati F.1:200; Synaptic Systems), rabbit anti-vGAT (131,003; 1:500; Synaptic Systems), mouse anti-Gephyrin (147,011; 1:500; Synaptic Systems), rabbit anti-GluA1 (182,003; 1:500; Synaptic Systems), rabbit anti-GABAA-β2

(20) High-content image-based pooled screens reveal regulators of synaptogenesisCell reportsJuly 22, 2025Le A, Biederer T, Blainey PC.131 003, RRID: AB_887869; 1:600 dilution) and mouse anti-Gephyrin antibody (Synaptic Systems, Cat# 147 011, RRID: AB_887717; 1:200 dilution), or guinea pig anti-VGLUT1 antibody (Sigma-Aldrich, Cat# AB5905, RRID:

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10/7/2020Determining the Inhibitory Synapses Using Anti-Gephyrin Antibody Bhavin ShahGFP transfected -hippocampal neurons were stained with anti-Gephyrin antibody after culturing them for 10 days in vitro (10DIV) to determine the gephyrin positive synapses.

Gephyrin Antibody

Gephyrin Antibody

Gephyrin Antibody

Gephyrin Antibody from Synaptic Systems GmbH

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Questions and Answers

Synaptic Systems GmbH

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Gephyrin Antibody from Synaptic Systems GmbH

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