SNAP25 antibody 111 011 from Synaptic Systems GmbH

Product Specs
ItemSNAP25 antibody
CompanySynaptic Systems GmbH
Price $435.00Supplier Page View Company Product Page
Catalog Number111 011
TargetSNAP25
IsotypeIgG1
Formatlyophilized
Quantity50 µg
ApplicationsWB, IP, ICC, IHC-P
Reactivityhuman, rat, mouse, vertebrates, zebrafish
Hostmouse
Clonalitymonoclonal
Cell Line71.1
Clone71.1
ImmunogenRecombinant protein corresponding to AA 1 to 206 from rat SNAP25B
ValidationKO
Antibody TypePrimary antibody

Questions and Answers

What species can I use this SNAP25 antibody on for my experiments?

The SNAP25 antibody has been shown to work on a wide range of species, including human, mouse, rat, zebrafish, various birds, and several other mammals, as well as invertebrates like C. elegans and Drosophila.

Has this antibody been utilized in any specific experimental applications?

Yes, the SNAP25 antibody has been utilized in various applications including Western blotting, immunocytochemistry, immunohistochemistry, immunoprecipitation, and electron microscopy, as evidenced by its citation in numerous scientific articles.

Can this antibody help in studying synaptic transmission and related disorders?

The SNAP25 antibody is crucial for studying synaptic transmission, as SNAP25 is a key component of the SNARE complex involved in neurotransmitter release. Research has shown that mutations in SNAP25 can affect synaptic exocytosis and are linked to neurological disorders, making this antibody valuable for such studies.

What kind of experimental results have been reported using this antibody?

Studies have reported using the SNAP25 antibody to investigate the effects of botulinum neurotoxins on SNAP25 cleavage, as well as to analyze the dynamics of synaptic vesicle exocytosis and the role of SNAP25 in neurotransmitter release, providing insights into synaptic function and pathology.

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) Distinct spatial patterning and transcriptomic landscapes of human neural organoids by localized delivery of morphogensCell Stem CellMarch 5, 2026Feiyu Yang, Narciso Pavon, Tatsuya Matsubara, Rebecca Sebastian, Beatriz Martinez-Martin, ChangHui Pak, Yubing Sun, Deok-Ho Kimanti-MAP2,Abcam,"Cat# ab5392, RRID: AB_2138153" Mouse Monoclonal anti-SNAP25,Synaptic System,"Cat# 111011, RRID: AB_2619779" Goat Polyclonal anti-OTX2,R&D Systems,"Cat# AF1979, RRID: AB_2157172" Goat Polyclonal

(2) SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ringCell ReportsFebruary 24, 2026Victoria Amstrup Vold, Jie Yang, Maiken Østergaard, Anna Schrøder Lassen, Anna Kádková, Avinash Kumar, Alexander M. Walter, Yongli Zhang, Jakob B. Sørensenovernight at 4°C with primary antibody in blocking solution (mouse α-SNAP-25 1:10000 Synaptic Systems 111011; rabbit α-VCP antibody 1:5000 Abcam AB109240; mouse α-VCP 1:2000 Abcam AB11433). After primary antibody,

(3) Antinociceptive properties of intravesical/needle-free administration of abobotulinumtoxinA in a rodent model of chronic visceral pain: in vivo and histological evidenceJournal of Neural TransmissionDecember 1, 2025Céline Augé, Mathieu Vogt, Vincent Martin, Stéphane Lezmi, Xavier Gamé, Philippe Lluel, Jacquie Maignel(c-SNAP25) with antibody EF14007 (IPSEN, France), the N-ter part of SNAP25 (SNAP25N-ter) with antibody 111 011 detecting both noncleaved and cleaved forms of SNAP25 (Synaptic Systems, Göttingen, Germany), beta-3

(4) Central biogenic amine deficiency with concomitant exploratory behavioral deficits in Dnajc12 knock-out miceNPJ Parkinson's diseaseMay 30, 2025Deng IB, Follett J, Fox JD, Wall S, Farrer MJ.FLAG (M2 clone, Millipore-Sigma, F3165; 1:5000), TH (Sigma, T2928, 1:1000); SNAP25 (Synaptic systems, 111011, 1:1000). Tissue collection and homogenization Mice were deeply anaesthetized via inhalation of isoflurane

(5) Septin5 deletion enhances β-cell exocytosis by releasing microtubule-tethered insulin granules onto plasma membraneNat CommunMarch 19, 2025Li Xie, Fei Kang, Tairan Qin, Youhou Kang, Tao Liang, Huanli Xie, Carol D. Froese, Hong Xie, Aaron Au, Christopher M. Yip, et al.antibody (catalog 610336) was from BD Transduction Laboratories (NULL, USA); SNAP25 antibody (catalog 111 011) was from Synaptic Systems GmbH (Goettingen, Germany). As gifts, Septin5 shRNA plasmid was from W S.

(6) Mouse-derived Synaptosomes Trypsin Cleavage Assay to Characterize Synaptic Protein Sub-localizationBio-protocolJanuary 20, 2025Shergill JK, Tehran DA.(Synaptic Systems, catalog number: 101011) 36. Anti-Snap25 antibody (Synaptic Systems, catalog number: 111011) 37. IRDye 800CW goat anti-Rabbit IgG secondary antibody (LI-COR, catalog number: 926-32211) 38. IRDye

(7) TBC1D24 interacts with the v-ATPase and regulates intraorganellar pH in neuronsiScienceJanuary 17, 2025Pepe S, Aprile D, Castroflorio E, Marte A, Giubbolini S, Hopestone S, Parsons A, Soares T, Benfenati F, Oliver PL, et al.1:1,1000",Abcam,Cat#ab50533; RRID:AB_882241 Mouse monoclonal anti-Snap25; WB 1:500,Synaptic System,Cat#111011; RRID:AB_887794 "Mouse monoclonal anti-synaptophysin1; WB 1:1,000",Synaptic System,Cat#101011; RRID:AB_887824 "Rabbit

(8) Key determinants of the dual clamp/activator function of ComplexineLifeNovember 25, 2024Mazen Makke, Alejandro Pastor-Ruiz, Antonio Yarzagaray, Surya Gaya, Michelle Zimmer, Walentina Frisch, Dieter BrunsSynaptic Systems (Göttingen, Germany) were used: Anti-Syntaxin1 (CL 78.2) No: 110 001; SNAP25 (CL 71.1), No:111 011; SynaptobrevinII (CL 69.1), No: 104 211; Synaptotagmin 1 (CL 41.1), No:105 011; Anti-Synapsin 1 (CL

(9) SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neuronsiScienceNovember 15, 2024Raveendran VA, Serranilla M, Asgarihafshejani A, de Saint-Rome M, Cherednychenko M, Mullany S, Mitchell JA, Pressey JC, Woodin MA.

(10) Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behavioursBrain : a journal of neurologyNovember 4, 2024Shi HJ, Xue YR, Shao H, Wei C, Liu T, He J, Yang YH, Wang HM, Li N, Ren SQ, et al.

(11) Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorderMolecular autismJune 14, 2024Simões de Oliveira L, O'Leary HE, Nawaz S, Loureiro R, Davenport EC, Baxter P, Louros SR, Dando O, Perkins E, Peltier J, et al.

(12) Intramuscular Botulinum Neurotoxin Serotypes E and A Elicit Distinct Effects on SNAP25 Protein Fragments, Muscular Histology, Spread and Neuronal Transport: An Integrated Histology-Based Study in the RatToxinsMay 12, 2024Martin V, Carre D, Bilbault H, Oster S, Limana L, Sebal F, Favre-Guilmard C, Kalinichev M, Leveque C, Boulifard V, et al.(SNAP25C-ter, INSERM U1325, region 198–206). The N-ter part of SNAP25 was detected by commercial antibody 111 011 (SNAP25N-ter, Synaptic Systems, region 20–40), which recognizes both noncleaved and cleaved forms of

(13) SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactionseLifeFebruary 27, 2024Anna Kádková, Jacqueline Murach, Maiken Østergaard, Andrea Malsam, Jörg Malsam, Fabio Lolicato, Walter Nickel, Thomas H Söllner, Jakob Balslev Sørensendescribed before (Ruiter et al., 2019). Incubation in primary antibodies (a-SNAP25: mouse, 1:10,000, SYSY 111011, Synaptic Systems; a-VCP: mouse, 1:2000, ab11433, Abcam) was performed overnight with 70 rpm shaking

(14) All SNAP25 molecules in the vesicle-plasma membrane contact zone change conformation during vesicle primingProceedings of the National Academy of Sciences of the United States of AmericaJanuary 9, 2024Zhao Y, Fang Q, Sharma S, Jakhanwal S, Jahn R, Lindau M.

(15) Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complexFrontiers in molecular neuroscienceJanuary 1, 2024Lux UT, Meyer J, Jahn O, Davison A, Babai N, Gießl A, Wartenberg A, Sticht H, Brose N, Reim K, et al.

(16) Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoidsNature communicationsJune 24, 2023Sebastian R, Jin K, Pavon N, Bansal R, Potter A, Song Y, Babu J, Gabriel R, Sun Y, Aronow B, et al.rabbit anti-HOMER (1:1000 Synaptic System 160003), and mouse anti-SYNAPSIN (1:500, Synaptic System 111011). Secondary antibodies conjugated with Alexa 488, 594, 647 (Invitrogen) and DAPI (1:1000, Sigma MBD0015)

(17) Synaptic biomarkers in the cerebrospinal fluid associate differentially with classical neuronal biomarkers in patients with Alzheimer's disease and frontotemporal dementiaAlzheimer's research & therapyMarch 24, 2023Das S, Goossens J, Jacobs D, Dewit N, Pijnenburg YAL, In 't Veld SGJG, Teunissen CE, Vanmechelen E.

(18) A synthetic organelle approach to probe SNARE-mediated membrane fusion in a bacterial hostThe Journal of biological chemistryMarch 1, 2023Ferreras S, Singh NP, Le Borgne R, Bun P, Binz T, Parton RG, Verbavatz JM, Vannier C, Galli T.anti-Syntaxin 1a (HPC-1) (STX01, AbCam), mouse mAb anti-SNAP-25 clone 71.1 (Synaptic System ref number: 111011), rabbit pAb anti-Munc18.1 (Synaptic System), mouse mAb anti-TeNT (light chain–specific T2/13 (42).

(19) Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and agingCell reportsFebruary 28, 2023Uzay B, Houcek A, Ma ZZ, Konradi C, Monteggia LM, Kavalali ET.

(20) Transformation of a Metal Chelate into a “Catch and Anchor” Inhibitor of Botulinum A ProteaseInternational Journal of Molecular SciencesFebruary 21, 2023Lucy Lin, Ealin N. Patel, Alexander L. Nielsen, Lewis D. Turner, William H. Tepp, Kong Nguyen, Sabine Pellett, Kim Jandaby Western blot using a monoclonal anti-SNAP-25 antibody (Synaptic Systems, Göttingen, Germany; cat. #111011) as described previously, and bands were visualized using Phosphaglo chemiluminescent reagent (KPL)

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SNAP25 antibody

SNAP25 antibody

SNAP25 antibody

SNAP25 antibody from Synaptic Systems GmbH

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Synaptic Systems GmbH

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SNAP25 antibody from Synaptic Systems GmbH

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