5-lipoxygenase activating protein Antibody bs-7556R from Bioss Inc.

Published Figures

Register or Sign In to View Figures.

Scientific Reports
March 19 2026

Fig 1: (A) Uniform Manifold Approximation and Projection (UMAP) visualization of 40,801 cells integrated from DKD and control samples, alongside bar plots showing cell counts and relative proportions across individuals. (B) Feature plot displaying the distribution of ALOX5 expression on the UMAP embedding. (C) UMAP plot showing the sub-clustering of the macrophage lineage into three subsets (CD14\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^+$$\end{document} Mono, CD86\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^+$$\end{document} mac, and CD163\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^+$$\end{document} mac), with stacked bar plots illustrating their compositional proportions. (D–F) Boxplots quantifying ALOX5 expression levels. (D) Comparison between control and DKD groups. (E) Expression across all annotated cell types split by group. (F) Expression among the three identified macrophage subpopulations. (ALOX5-positive cells after zero filtering) (G) Pseudotime trajectory analysis of macrophage differentiation constructed using Monocle3, colored by cell subtype. (H) Kinetic plots showing the expression dynamics of ALOX5 and ALOX5AP along the pseudotime trajectory. Statistical significance: \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$***P < 0.001$$\end{document}, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$****P < 0.0001$$\end{document}.
Register or Sign In to View Figures.

Scientific Reports
March 19 2026

Fig 2: Representative immunohistochemistry (IHC) images retrieved from the Human Protein Atlas (HPA) database. The panels display the baseline protein expression levels of ALOX5, ALOX5AP, CYSLTR1, and RELA (NF-\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\kappa$$\end{document}B p65) in normal renal tissue microarrays.
Register or Sign In to View Figures.

Scientific Reports
March 19 2026

Fig 3: Multiplex immunohistochemical (mIHC) analysis of ALOX5 pathway components and macrophage phenotypes in DKD renal tissues. Representative immunofluorescence images from renal biopsies of three independent DKD patients. The panels display single-channel and merged staining for the core pathway proteins (ALOX5, ALOX5AP, CYSLTR1), the pan-macrophage marker (CD68), polarization markers (iNOS for pro-inflammatory; CD163 for anti-inflammatory), and the inflammatory transcription factor (NF-\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\kappa$$\end{document}B). High-magnification insets illustrate the spatial co-localization patterns of these proteins within the renal tubules. Nuclei were counterstained with DAPI. Scale bars: \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$100\ \mu \textrm{m}$$\end{document} (low magnification) and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$25\ \mu \textrm{m}$$\end{document} (high magnification). The complete multichannel composite image is provided in Supplementary Fig. 4.
Register or Sign In to View Figures.

Scientific Reports
March 19 2026

Fig 4: Proposed mechanism of the ALOX5/ALOX5AP–leukotriene–CysLTR1 axis in DKD. Infiltrating monocytes/macrophages upregulate ALOX5AP/ALOX5 to convert arachidonic acid into cysteinyl leukotrienes (LTC\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_4$$\end{document}, LTD\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_4$$\end{document}, LTE\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_4$$\end{document}), which signal through CysLTR1 and activate PLC/PKC-mediated Ca\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^{2+}$$\end{document} influx, leading to IKK activation, I\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\kappa$$\end{document}B\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\alpha$$\end{document} degradation, and NF-\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\kappa$$\end{document}B nuclear translocation. This results in increased production of pro-inflammatory mediators (IL-6, TNF-\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\alpha$$\end{document}, IL-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\beta$$\end{document}, MCP-1, ICAM-1, VCAM-1) and promotes tubulointerstitial inflammation.

Be the first to write a review!

Citations:

(2)

Figures:

Supplier Page

Supplier Page from
Bioss Inc. for
5-lipoxygenase activating protein Antibody

The 5-lipoxygenase activating protein Antibody from Bioss Inc. is a Rabbit Polyclonal antibody. This antibody recognizes Mouse, and Rat antigen. The 5-lipoxygenase activating protein Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.

Description

Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes

Scientific Reports

Scientific Reports

Scientific Reports

Scientific Reports

5-lipoxygenase activating protein Antibody from Bioss Inc.

Description

Bioss Inc.

Citations (2)

Reviews

5-lipoxygenase activating protein Antibody from Bioss Inc.

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map