CD3 Antibody (SP7) from Novus Biologicals, a Bio-Techne Brand

The CD3 antibody (SP7) has been shown to work effectively in immunohistochemistry applications with various species, including humans, mice, and canines, as indicated in multiple studies.

Yes, the CD3 antibody has been utilized in studies related to neurodegeneration, particularly in the context of tauopathies, where it was used to assess T cell infiltration in mouse models of Alzheimer's disease (chen2023). It has also been employed in research on lung cancer, where it was part of a multiplexed quantitative immunofluorescence analysis to evaluate T cell responses in non-small cell lung carcinoma (gettinge2018).

In immunofluorescence applications, the CD3 antibody (SP7) is typically used at a dilution of 1:10, as demonstrated in various studies (delcroix2023).

Research utilizing the CD3 antibody has revealed significant insights into T cell behavior, such as the identification of a "dormant" T cell phenotype associated with sensitivity to immune checkpoint blockers in lung cancer, highlighting the antibody's role in understanding T cell dynamics in tumor environments (gettinge2018).