Tau (TAU-5) Antibody sc-58860 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemTau (TAU-5) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-58860
Antibody TypePrimary Antibodies
NCBI Gene AliasesTau, Tau-PHF6, TAU, tau-40, PPND, DDPAC, FTDP-17, MTBT2, PHF-tau, PPP1R103, MSTD, Mtapt, MTBT1, MAPTL
Quantity200 µg/ml
CloneTAU-5
ApplicationsWB, IP, IF, IHC(P)
Reactivitymouse, rat, human, bovine
Hostmouse
Conjugate/TagUnconjugated
FormatPurified
ClonalityMonoclonal
NCBI Full Gene Namemicrotubule-associated protein tau, microtubule associated protein tau
TargetTau
IsotypeIgG1

Questions and Answers

What species does this Tau antibody react with, and how has it been utilized in research?

The Tau (TAU-5) antibody reacts with mouse, bovine, human, and rat species. It has been shown to work in applications such as Western blotting and immunohistochemistry, where it has been used to detect Tau protein levels and modifications in various studies, including those investigating neurodegenerative diseases like Alzheimer's disease (, ).

Can this antibody be used to study Tau pathology in Alzheimer's disease models?

Yes, the Tau (TAU-5) antibody has been utilized in studies examining Tau pathology in Alzheimer's disease models. For instance, it was employed to assess Tau modifications and aggregation in transgenic mouse models, highlighting its role in neurodegeneration and cognitive impairment (, ).

How has the Tau (TAU-5) antibody been applied in immunofluorescence studies?

The Tau (TAU-5) antibody has been effectively used in immunofluorescence studies to visualize Tau protein in brain tissue sections. It has been part of protocols that demonstrate the antibody's ability to maintain signal integrity even after multiple staining cycles, making it suitable for high-dimensional analysis of brain tissue ().

What are some specific applications of the Tau (TAU-5) antibody in experimental settings?

The Tau (TAU-5) antibody has been applied in various experimental settings, including Western blotting for protein quantification, immunofluorescence for localization studies, and immunohistochemistry for examining tissue sections. It has been cited in studies focusing on neuroinflammation, Tau hyperphosphorylation, and the effects of therapeutic interventions in Alzheimer's disease models (, ).

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairmentsJournal of Advanced ResearchMarch 1, 2026Ling Lei, Qian Guo, Yilei Cheng, Yuran Gui, Wensheng Li, Yiheng Zhao, Zhendong Xu, Yong Luo, Gang Wu, Jian-Zhi Wang, et al.Antibodies,Specific,Type,Source NR4A1,Anti-NR4A1,pAb,Bioss (bs-3513R) NR4A1,Anti-NR4A1,pAb,Abcam (ab153914) Tau5,Anti-Total tau,mAb,Santa Cruz (sc-58860) AT8,"Anti-Phosphorylated tau at Ser202, Thr205",mAb,Invitrogen (MN1020) pT181,Anti-Phosphorylated

(2) Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cellsiScienceFebruary 20, 2026Elisa Balzano, Shyam Twayana, Settapong T. Kosiyatrakul, Glennis A. Logsdon, Bhushan L. Thakur, Evan E. Eichler, Bettina Bohl, Philipp Koch, Simone Sidoli, Anupama Kumari, et al.were anti-actin tag (rabbit polyclonal, Sigma, A2066), anti-human Tau (human monoclonal, Santa Cruz, sc-58860). Following incubation with primary antibodies membranes were washed with 0.1% Tween-20/1xPBS. Membranes

(3) Loss of CAMKK2 and iron-transport proteins—transferrin and its receptor—in the Alzheimer’s disease hippocampus: link to tau pathologyFrontiers in Cell and Developmental BiologyJanuary 22, 2026Mohammad Golam Sabbir, Behzad Mansouri, Bram Ramjiawansc-365871), TFRC (1:1000; Santa Cruz Biotechnology, sc-51829), MAPT (1:1000; Santa Cruz Biotechnology, sc-58860), and GAPDH (1:5000; Santa Cruz Biotechnology, sc-25778). The CAMKK2, TF, TFRC, MAPT, and GAPDH antibodies

(4) Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy miceCell ReportsOctober 28, 2025Alejandro Martín-Ávila, Swananda R. Modak, Hameetha B. Rajamohamedsait, Andie Dodge, Dov B. Shamir, Senthilkumar Krishnaswamy, Leslie A. Sandusky-Beltran, Marilyn Walker, Yan Lin, Erin E. Congdon, et al.Tween 20 in TBS for 1 h, and incubated with different antibodies at 4°C overnight (Tau-5 (Santa Cruz, sc-58860, 1:1,000, tau epitope 210–241), CP27 (1:1000, recognizes human tau epitope 130–150 but not mouse tau,

(5) Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activityElifeOctober 9, 2025Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kanganti-legumain (AEP) (1:400; sc-133234, Santa Cruz), mouse anti-TAU-5 (1:1500, Santa Cruz Biotechnology, SC-58860), and mouse anti-beta actin (1:12800, 66009-1-Ig, Proteintec, Rosemont, IL, USA) (Figure 5A, D and G);

(6) Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activityeLifeOctober 9, 2025Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kanganti-legumain (AEP) (1:400; sc-133234, Santa Cruz), mouse anti-TAU-5 (1:1500, Santa Cruz Biotechnology, SC-58860), and mouse anti-beta actin (1:12800, 66009-1-Ig, Proteintec, Rosemont, IL, USA) (Figure 5A, D and G);

(7) Far-Infrared Radiation Ameliorates the Cognitive Dysfunction in an Alzheimer's Disease Transgenic Mouse via Modulating Jak-2/Stat3 and Nrf-2/HO-1 PathwaysNeuromolecular medicineMay 15, 2025Yang W, Yu Q, Wang N, Lam KK, Lin ZX, Xian YF.and activator of transcription 3 (Stat3) (1:1000, 12640S, Cell Signaling Technology), Tau 5 (1:500, sc-58860, Santa Cruz), and GAPDH (1:5000, ab8245, Abcam). After rinsing in Tris-buffered saline containing Tween

(8) Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is associated with abnormal iron homeostasis: implications for patient survivalFrontiers in Cell and Developmental BiologyNovember 28, 2024Mohammad Golam Sabbiranti-TF (catalog number: sc-365871), anti-TFRC (catalog number: sc-51829), anti-MAPT (catalog number: sc-58860), anti-CHRM1 (catalog number: sc-365966) and anti-GAPDH (catalog number: Sc-25778) antibodies were purchased

(9) TSWIFT, a novel method for iterative staining of embedded and mounted human brain sectionsScientific ReportsJune 3, 2024Corey M. Porter, Sarah Tabler, Sooin Choi, Matthias C. Truttmannimages from cycles of staining post-SHIELD. All are stained with DAPI at 50 µg/mL (Blue), Santa Cruz sc-58860 mouse mAb Tau (secondary 568) (Red) and DAKO Z0334 rabbit pAb GFAP (secondary 488) (Green). (A): cycle

(10) TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathyActa NeuropathologicaJune 1, 2024George A. Edwards, Caleb A. Wood, Yang He, Quynh Nguyen, Peter J. Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, et al.(pThr231, ThermoFisher MN1040), AT270 (pThr181, ThermoFisher MN1050); TAU-5 (total tau, Santa Cruz sc-58860), and Ck anti-GAPDH (Millipore AB2302). The following day, membranes were washed in TBS containing 0.1%

(11) Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathwayJournal of neuroinflammationJanuary 30, 2023Xu QQ, Su ZR, Yang W, Zhong M, Xian YF, Lin ZX.(1:1000, A8717, Sigma), insulin degrading enzyme (IDE) (1:500, sc-393887, Santa Cruz), Tau (Tau 5) (1:500, sc-58860 Santa Cruz), p-Tau (Thr181) (1:1000, 12885S, Cell Signaling Technology), p-Tau (Thr205) (1:1000, ab254410,

(12) Patchouli alcohol ameliorates the learning and memory impairments in an animal model of Alzheimer's disease via modulating SIRT1Phytomedicine : international journal of phytotherapy and phytopharmacologyNovember 1, 2022Xu QQ, Su ZR, Hu Z, Yang W, Xian YF, Lin ZX.

(13) Toluidine blue O attenuates tau phosphorylation in N2a-APPSwe cellsChemico-biological interactionsOctober 1, 2022Onder S, Biberoglu K, Yuksel M, Tacal O.

(14) Bilateral intracerebroventricular injection of streptozotocin induces AD-like behavioral impairments and neuropathological features in mice: Involved with the fundamental role of neuroinflammationBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieSeptember 1, 2022Fan M, Liu S, Sun HM, Ma MD, Gao YJ, Qi CC, Xia QR, Ge JF.

(15) Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagationNature structural & molecular biologyApril 1, 2022Kang SS, Meng L, Zhang X, Wu Z, Mancieri A, Xie B, Liu X, Weinshenker D, Peng J, Zhang Z, et al.membrane. The used primary antibodies for the detection of proteins are as follows: Tau5 (Santa Cruz, SC-58860, 1:1500 dilution), AT-8 (Thermo Fisher Scientific, MN1020, 1:500 dilution), beta-actin (Sigma-Aldrich,

(16) Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathologyJournal of neuroinflammationFebruary 7, 2022Liu S, Fan M, Xu JX, Yang LJ, Qi CC, Xia QR, Ge JF.dilution ratios were as follows: anti-Aβ1−42 (1:1000; 25524-1-AP, Proteintech), anti-Tau5 (1:1000; sc-58860, Santa Cruz), anti-p-Tau (Ser396) (1:1000; sc-32275, Santa Cruz), anti-BACE (1:500; WL02795, Wanleibio),

(17) The metabolic signaling of the nucleoredoxin-like 2 gene supports brain functionRedox biologyDecember 1, 2021Jaillard C, Ouechtati F, Clérin E, Millet-Puel G, Corsi M, Aït-Ali N, Blond F, Chevy Q, Gales L, Farinelli M, et al.probed with mouse monoclonal anti-TAU antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA, Cat# sc-58860, RRID: AB_785931, 1/500). To study TAU expression, oligomerization and phosphorylation, extracts from

(18) Dynamic interactions and Ca(2+)-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seedingNature communicationsNovember 1, 2021Moreira GG, Cantrelle FX, Quezada A, Carvalho FS, Cristóvão JS, Sengupta U, Puangmalai N, Carapeto AP, Rodrigues MS, Cardoso I, et al.MO, USA) and 5% goat serum (Cat. X0907, Agilent Technologies, Santa Clara, CA, USA). Anti-tau (Cat. sc-58860, Santa Cruz Biotechnology, Dallas, TX, USA) and anti-S100B (Cat. ab-52642, Abcam, Cambridge, UK) antibodies

(19) Comparison of the chemical constituents and anti-Alzheimer's disease effects of Uncaria rhynchophylla and Uncaria tomentosaChinese medicineOctober 27, 2021Xu QQ, Shaw PC, Hu Z, Yang W, Ip SP, Xian YF, Lin ZX.anti-Tau (Tau 46) antibody (1:500, Santa Cruz, sc-32274), mouse anti-Tau (Tau 5) antibody (1:500, Santa Cruz, sc-58860), rabbit anti-p-Tau (Thr181) antibody (1:1000, Cell Signaling, 12885S), rabbit anti-p-Tau (Ser396) antibody

(20) ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's diseaseActa neuropathologicaJuly 1, 2021Kang SS, Ahn EH, Liu X, Bryson M, Miller GW, Weinshenker D, Ye K.membrane, after SDS-PAGE. Primary antibodies to the following targets were used: Tau5 (Santa Cruz, SC-58860), AT-8 (Thermo Fisher Scientific, MN1020), beta-actin (Sigma-Aldrich, A5316), AEP (Cell signaling, 93627S),

Be the First to Write a Review!

Tau (TAU-5) Antibody

Tau (TAU-5) Antibody from Santa Cruz Biotechnology, Inc.

Description

Questions and Answers

Santa Cruz Biotechnology, Inc.

Citations (45)

Reviews

Tau (TAU-5) Antibody from Santa Cruz Biotechnology, Inc.

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map