CD206 (15-2) Antibody sc-58986 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemCD206 (15-2) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-58986
Quantity200 µg/ml
Reactivitymouse, rat, human
ApplicationsWB, IP, IF, FCM
Conjugate/TagUnconjugated
FormatPurified
Antibody TypePrimary Antibodies
Clone15-2
Hostmouse
TargetCD206
IsotypeIgG1
NCBI Gene AliasesCLEC13D, hMR, MMR, CLEC13DL, CD206, MR, bA541I19.1, MRC1L1
ClonalityMonoclonal
NCBI Full Gene Namemannose receptor C-type 1, mannose receptor, C type 1

Questions and Answers

What applications has the CD206 (15-2) antibody been used for in scientific research?

The CD206 (15-2) antibody has been shown to work in various applications including Western Blotting, Flow Cytometry, Immunofluorescence, and Immunoprecipitation. It has been utilized in studies to analyze macrophage polarization and inflammation, as evidenced by its use in immunofluorescence staining to differentiate between M1 and M2 macrophages in various experimental models.

Can this antibody be used to study macrophage polarization in vivo?

Yes, the CD206 (15-2) antibody has been employed in in vivo studies to assess macrophage polarization. For instance, it was used in research investigating the effects of human adipose tissue-derived small extracellular vesicles on macrophage polarization, demonstrating its utility in analyzing M2 macrophage markers in tissue samples.

Is the CD206 (15-2) antibody effective for detecting CD206 expression in mouse models?

The CD206 (15-2) antibody is effective for detecting CD206 expression in mouse models, as indicated by its application in various studies involving mouse tissues. It has been cited in research focusing on neuroinflammation and macrophage activation, confirming its specificity and reliability in mouse systems.

What species does the CD206 (15-2) antibody react with?

The CD206 (15-2) antibody is reactive with multiple species, including humans, mice, and rats. This broad reactivity makes it a versatile tool for studying CD206 across different biological contexts and experimental setups.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) A preclinical investigation into the potential associations of geraniin with ulcerative colitis alleviation through integrated multi-omics and in vivo analysisFront Med (Lausanne)May 13, 2026Chang Cheng, Wei Wang, Tingting Zheng, Xiangmin Shi, Chong FuAB208670), F4/80 (Proteintech, 28463-1-AP), CD86 (BIOSS, bs-1035R), and CD206 (Santa Cruz Biotechnology, SC-58986). Tissue sections were incubated with these primary antibodies overnight at 4 °C. After thorough rinsing

(2) Changes in the microglial phenotype drive neuroinflammation independent of systemic inflammation in the acute stage of heatstrokeiScienceApril 17, 2026Ping Li, Zeze Wang, Jun Liu, Gong Wang, Xue Luo, Zhen Luo, Tingting Shen, Genlin He, Xuesen YangTMEM119(27585-1-AP; Proteintech, China), mouse anti-rat CD86 (ab119857; abcam, USA), and goat anti-mouse CD206 (sc-58986; Santa Cruz, USA) antibodies at 4°C overnight. Following incubation with the corresponding secondary

(3) Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injuryCell Death DiscoveryMarch 27, 2026Xinjie Li, Haomiao Yuan, Shuyang Mu, Jiaqing Pan, Fuyuan Zhang, Shukui Du, Jin Liu, Anran Qu, Yingfu Sun, Linlin Wang, et al.sc393656, Santa Cruz), NLRP3 (1:200, 15101S, CST), CD86 (1:200, sc-28347, Santa Cruz), CD206 (1:200, sc58986, Santa Cruz), caspase-1 (1:200, 22915-1-AP, Proteintech), eMyHC (1:50, F1.652, DSHB), Myogenin (1:200,

(4) Nature-inspired confined cascade enzyme nanoreactors for targeted atherosclerosis therapySignal Transduct Target TherMarch 9, 2026Yuehuang Wu, Hongping Xia, He Ding, Mengmeng Long, Sen Yan, Miao Zhang, Jingyi Sheng, Ning Gu36169S), β-actin (Cell Signaling Technology, 4967), Arg1 (Santa Cruz, sc-271430), CD206 (Santa Cruz, sc-58986), ICAM-1 (Santa Cruz, sc-390483), iNOS (Proteintech, 22226-1-AP), CD86 (Proteintech, 83213-5-RR), and

(5) Targeted inhibition of M2 macrophages polarization via a PDC attenuates chronic pancreatitis through the PPARα pathwayiScienceFebruary 20, 2026Xin Kong, Xufeng Tao, Hong Xiang, Fangyue Guo, Yu Wu, Jing Lv, Xinya Zhao, Xiaonan Zhang, Zhiwen Zhai, Deshi DongIgG (H+L),ABclonal,Cat# AS014; RRID:AB_2769854 CD206/Mannose Receptor/MMR Antibody,Santa Cruz,Cat# sc-58986; RRID:AB_2144945 CD68 Antibody (KP1),Santa Cruz,Cat# sc-20060; RRID:AB_627158 APC anti-mouse F4/80

(6) Spatiotemporal Co‐Delivery of Hydrogen and Magnesium via Microneedle Patches for Neuroinflammation Modulation After Spinal Cord Injury: A Multi‐Modal In Vivo StudySmallFebruary 16, 2026Haibo Wang, Yang Sun, Shiqi Wang, Wenbo Wang, Jincheng Tang, Ziang Li, Xinzhao Jiang, Liang Zhou, Jie Wu, Qiangqiang Guo, et al.antibodies: CD11b (Biolegend, 201805, 1:200), CD86 (Biolegend, 200307, 1:200), and CD206 (Santa Cruz, sc‐58986, 1:200) at 4°C for 30 min, followed by fixation with 1% PFA. The proportions of CD11b+/CD86+ and CD11b+/CD206+

(7) TRPV1 manipulating polarization of M1/M2 macrophages to promote skeletal muscle regenerationSkeletal MuscleFebruary 3, 2026Jinfang Liu, Na Li, Shuwei Jing, Fangyu Wu, Guoshuai An, Liangliang Wang, Jian Li, Ximei Cao, Junhong SunSanta Cruz Biotechnology, sc-28347); mouse anti-CD206 polyclonal antibody (1:200, Santa Cruz Biotechnology, sc-58986); rat anti-F4/80 monoclonal antibody (1:100, Abcam, ab1691); rabbit anti-F4/80 monoclonal antibody (1:200,

(8) High-entropy alloy Janus artificial enzymes for pH-gated sequential redox therapy of drug-resistant bacterial infectionNature CommunicationsJanuary 20, 2026Cong Han, Yongqi Wang, Shihuan Gao, Ting Wang, Huili Du, Jie Long, Weidong Tian, Mohsen Adeli, Liang Cheng, Zhi Liu, et al.abcam, USA, 1:100 dilution), iNOS (sc-7271, Santa Cruz Biotechnology, USA, 1:200 dilution), CD206 (sc-58986, Santa Cruz Biotechnology, USA, 1:200 dilution), F4/80 (sc-25830, Santa Cruz Biotechnology, USA, 1:100

(9) Targeted Infection Control and Tissue Integration via pH-Sensitive Smart Coatings on Implant SurfacesACS Applied Materials & InterfacesJanuary 14, 2026Marta Maria Alves Pereira, Rodolfo Debone Piazza, Paula Aboud Barbugli, Oya Tagit, Jeroen J.J.P. van den Beucken, Abhijna Das, Cleyton Alexandre Biffe, Valentim Adelino Ricardo Barão, Stéfany Barbosa Alves da Cruz, Edilson Ervolino, et al.NOS2 antibody (sc649, 1:100; Santa Cruz Biotechnology, Dallas, TX, USA); and mouse CD206 antibody (sc58986, 1:100; Santa Cruz Biotechnology, Dallas, TX, USA). For signal amplification, biotinylated horse antimouse/rabbit

(10) cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activation of the TREM2-DAP10-PI3K PathwayInflammationJanuary 6, 2026Xinyu Li, Huamin Ding, Shuyu Qian, Zhiqi Hou, Guoling Yang, Yulin Ma, Yuan Gao, Yuefan Zhang, Tiejun Li(Santa Cruz, catalog number sc-166711), Iba-1 antibody (Abcam, ab178847), CD206 antibody (Santa Cruz, sc-58986), primary antibody dilution buffer (Servicebio, G2025-100), anti-rabbit IgG antibody (Cell Signaling,

(11) HDAC1 dysregulation promotes pro-inflammatory microglial activation and aggravates post-stroke neuroinflammationAnn MedDecember 13, 2025Jui-Shen Chen, Hao-Kuang Wang, Yu-Ting Su, Yu-Cheng Ho, Cheng-Loong Liang, Yung-Kuo Lee, Tian-Huei Chu, Yun-Shin Lin, Cheng-Chun WuIba-1 (Genetex GTX635363, Xinbei, Taiwan; 1:300), CD86 (Genetex GTX635363; 1:200), CD206 (Santa Cruz sc-58986; Dallas, Texas; 1:150), CD3 (GTX16669; 1:300). For visualization, AlexaFluor-conjugated secondary antibodies

(12) Multi-modal integration of histopathology and transcriptomics reveals STAB1+ macrophage-associated efferocytosis as a suppressive immune mechanism in colon adenocarcinomaJ Transl MedDecember 8, 2025Zhanhao Chang, Chongli Zhong, Shuo Xu, Yuyang Zhang, Xingqi Guo, Jielin Yu, Zitong Xu, Shukun Han, Bing Han, Chao Lv, et al.include:STAB1 (1:1000, ABIN7075722, antibodies-online)ARG1 (1:1000, sc-47715, Santa Cruz)CD206 (1:1000, sc-58986, Santa Cruz)LRP1 (1:10000, ab92544, Abcam)MERTK (1:10000, ab95925, Abcam)TIM-3 (1:1000, A2516, ABclonal)p-S6

(13) Engineering macrophage phenotype switching via nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome inhibition: A translational approach using antibiotic cement for diabetic foot ulcersBioengineering & Translational MedicineNovember 1, 2025Yi Zhang, Fusen Jia, Ming Li, Xin Tang, Fei Yangwith primary antibodies against TNF‐α (ab1793, 5 μg/mL, Abcam), iNOS (ab283655, 1:50, Abcam), CD206 (sc‐58986, 1:500, Santa Cruz), and CD163 (ab316218, 1:50, Abcam). After washing with PBS three times for 5 min,

(14) Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cellsWorld Journal of GastroenterologyOctober 28, 2025Alejandro Escobedo-Calvario, Lisette Chávez-Rodríguez, Verónica Souza-Arroyo, Leticia Bucio-Ortiz, Roxana U Miranda-Labra, Felipe Masso, Araceli Páez-Arenas, Rogelio Hernández-Pando, Jens Marquardt, María Concepción Gutiérrez-Ruiz, et al.was performed by analyzing 1 × 104 events in duplicate. The CD206 antibody (Santa Cruz Biotechnology, sc-58986, TX, United States) was used to identify M2-like macrophage subsets. The specifications of primary and

(15) Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cellsWorld J GastroenterolOctober 28, 2025Alejandro Escobedo-Calvario, Lisette Chávez-Rodríguez, Verónica Souza-Arroyo, Leticia Bucio-Ortiz, Roxana U Miranda-Labra, Felipe Masso, Araceli Páez-Arenas, Rogelio Hernández-Pando, Jens Marquardt, María Concepción Gutiérrez-Ruiz, et al.was performed by analyzing 1 × 104 events in duplicate. The CD206 antibody (Santa Cruz Biotechnology, sc-58986, TX, United States) was used to identify M2-like macrophage subsets. The specifications of primary and

(16) Bone marrow mesenchymal stem cells alleviate smoke inhalation injury by regulating alveolar macrophage polarization via the CD200-CD200R pathwayFrontiers in ImmunologyOctober 27, 2025Ziling Ding, Yong Zhuang, Yunlong Zhao, Jie Shi, Xiaoqin Guo, Haojun Fan, Qi LvSanta Cruz Biotechnology, USA), PE-anti-iNOS (sc-7271, Santa Cruz Biotechnology, USA), FITC-anti-CD206 (sc-58986, Santa Cruz Biotechnology, USA) or FITC-anti-Arg-1 (sc-81154, Santa Cruz Biotechnology, USA) for 30

(17) Hypobaric hypoxia aggravates neuroinflammation in ligature-induced periodontitis mice via the STAT3 signaling pathwayFrontiers in ImmunologyJuly 29, 2025Lu Chen, Jiayi Zhang, Xuechao Fei, Jiajing Wang, Jiayue Gao, Xiangpei Yue, Yaqun Jiang, Zibi Shi, Shaojie Zhang, Xiufang Jiang, et al.019-19741, Wako), GFAP (Cat: MAB360, Millipore), CD16/32 (Cat: 553142, BD Biosciences), and CD206 (Cat: sc-58986, Santa Cruz). After washing with PBS, the sections were incubated for 1 hour in the dark with fluorescent

(18) RAGE Is Essential for Subretinal Fibrosis in Laser-Induced Choroidal Neovascularization: Therapeutic ImplicationsInvest Ophthalmol Vis SciJune 9, 2025Parameswaran G. Sreekumar, Mi-Hyun Nam, Elise Hong, Ram Kannan, Ram H. Nagaraj(#5339S) p-ERK,Rabbit,1:1000,Cell Signaling Technology (#4370S) CD206,Mouse,1:100,Santa Cruz Biotechnology (#sc-58986) ERK,Rabbit,1:1000,Cell Signaling Technology (#4695S) β-actin,Rabbit,1:5000,Cell Signaling Technology

(19) Postoperative analgesia with morphine promoting microglial activation and neuroinflammation induced by surgery aggravates perioperative neurocognitive dysfunction in aged miceIBRO Neuroscience ReportsJune 1, 2025Xiuzhi Shao, Liping Xie, Jingwen Zhai, Mingyue GeAbcam, UK), Arg1 (1:1000, sc-F0915, Santa Cruz, USA), CD86(1:1500, ab242142, Abcam, UK), CD206(1:200, sc-58986, Santa Cruz, USA), SYN (1: 1000, ab176562, Abcam, UK), PSD95 (1: 2000, ab18258, Abcam, UK), GAPDH (1:1000,

(20) Caveolin-1 Deficiency in Macrophages Alleviates Carbon Tetra-Chloride-Induced Acute Liver Injury in MiceInt J Mol SciMay 20, 2025Ruirui Li, Yixue Shu, Yulin Yan, Junyi Zhu, Zilu Cheng, Jie Zhang, Liming Zhu, Yanhua Qiao, Quan SunPEcy7-CD11b (Abcam, Cambridge, UK, ab218786), and PE-CD206 (Santa Cruz Biotechnology, Paso Robles, CA, USA, sc-58986) were used in flow cytometry analysis at recommended concentrations. Following a 30-min incubation in

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CD206 (15-2) Antibody

CD206 (15-2) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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CD206 (15-2) Antibody from Santa Cruz Biotechnology, Inc.

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