Anti-ROCK2 (phospho Ser1366) antibody GTX122651 from GeneTex

Product Specs
ItemAnti-ROCK2 (phospho Ser1366) antibody
CompanyGeneTex
Price $169.00Supplier Page
Catalog NumberGTX122651
ApplicationsWB, IA, IHC-fr, IHC-p, ICC, IF
ReactivityHu, Ms, Rt
FormatPBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300
NCBI Full Gene NameRho associated coiled-coil containing protein kinase 2
NCBI Gene AliasesROCK-II, Rho associated coiled-coil containing protein kinase 2, ROCK-II
ImmunogenCarrier-protein conjugated synthetic peptide surrounding phospho Ser1366 of human ROCK2. The exact sequence is proprietary
Gene NameROCK2
Molecular Weight161
Modificationsphospho
Research AreaCell Biology
TargetROCK2 (phospho Ser1366)
PurityPurified by antigen-affinity chromatography
Antibody TypePrimary Antibodies
HostRabbit
IsotypeIgG
ClonalityPolyclonal
Conjugate/TagUnconjugated
Concentration1.46mg/ml
Quantity25 µl

Questions and Answers

Can this antibody be used to study ROCK2 activity in T lymphocytes?

Yes, the Anti-ROCK2 (phospho Ser1366) antibody has been utilized in research demonstrating its role in T lymphocyte division, where it was shown to mediate phosphorylation of vimentin, crucial for maintaining cell shape during cytokinesis ().

Is this antibody effective for immunoblotting applications?

The Anti-ROCK2 (phospho Ser1366) antibody has been successfully used in immunoblotting, as indicated by its application in various studies, including those assessing the effects of different treatments on ROCK2 phosphorylation levels (; ).

What species can this antibody be used on?

This antibody recognizes ROCK2 in human, mouse, and rat samples, making it suitable for studies involving these species.

Has this antibody been cited in any studies related to neuronal signaling or behavior?

Yes, the Anti-ROCK2 (phospho Ser1366) antibody has been referenced in studies investigating the effects of cocaine on dendritic spine rearrangement in the prelimbic cortex, highlighting its relevance in neuronal signaling pathways ().

GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCPLife science allianceDecember 1, 2024Rehmani T, Dias AP, Applin BD, Salih M, Tuana BS.ProteinTech,"1:1,000", DVL2,ab22616; Abcam,"1:1,000", DVL3,CS 3218; Cell Signaling,"1:1,000", Phospho-ROCK2 (S1366),GTX122651; GeneTex,"1:1,000", ROCK2,sc-398519; Santa Cruz Biotechnology,"1:1,000", Phospho-cofilin (S3),3313T;

(2) SLMAP3 is crucial for organogenesis through mechanisms involving primary cilia formationOpen biologyOctober 1, 2024Dias AP, Rehmani T, Applin BD, Salih M, Tuana B.639,rabbit,1:1000 Cofilin (D3F9) XP,Cell Signaling,5175,rabbit,1:1000 Phospho-ROCK2 (S1366),GeneTex,GTX122651,rabbit,1:750 ROCK2 (D-11),Santa Cruz,SC-398519,mouse,1:200 Phospho-SAPK/JNK (Thr183/Tyr185) (81E11),Cell Signaling

(3) Oleuropein enhances proteasomal activity and reduces mutant huntingtin-induced cytotoxicityFrontiers in pharmacologyJanuary 1, 2024Huang ZN, Lee SY, Chen JM, Huang ZT, Her LS.Cell Signaling), anti-SAPK/JNK (#9252, 1:1,000, Cell Signaling), anti-Phospho-ROCK2 (phosphor Ser1366) (GTX122651, 1:1,000, GeneTex), anti-ROCK2 (GTX108247, 1:1,000, GeneTex), anti-Tubulin (T6074, 1:5,000; Sigma),

(4) Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortexiScienceApril 21, 2023Sequeira MK, Swanson AM, Kietzman HW, Gourley SL.domain,Rabbit,Cell Signaling Technology,3292S,1:1000 anti-p-ROCK2,Proprietary sequence,Rabbit,GeneTex,GTX122651,1:1000 anti-ROCK2,aa 1-100,Rabbit,Abcam,ab71598,1:500 anti-p-LIMK,Proprietary sequence,Rabbit,Cell Signaling Technology

(5) Cannabinoid CB(1) receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in miceCell death & diseaseJuly 7, 2022Sánchez-de la Torre A, Aguado T, Huerga-Gómez A, Santamaría S, Gentile A, Chara JC, Matute C, Monory K, Mato S, Guzmán M, et al.(1:500, Cytosqueleton Cat# ARH03, RRID:AB_10708069), pROCK2 (1:750, Genetex, Hsinchu City, Taiwan Cat# GTX122651, RRID:AB_2560946), pCofilin (1:500, Cell Signaling Technology Cat# 3313, RRID:AB_2080597) and anti-α-tubulin

(6) TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent mannerActa pharmaceutica Sinica. BDecember 1, 2021Zheng H, Li X, Zeng X, Huang C, Ma M, Lv X, Zhang Y, Sun L, Wang G, Du Y, et al.Antibodies to p-ROCK1 (C00666H, SAB) were from Signalway Antibody (SAB, China). Antibodies to p-ROCK2 (GTX122651) were from GeneTex Biotechnology (GeneTex, USA). Antibodies to p-MYPT1 (04–773) and RhoA (05–778) were

(7) RAB7A Regulates Vimentin Phosphorylation through AKT and PAKCancersMay 6, 2021Romano R, Calcagnile M, Margiotta A, Franci L, Chiariello M, Alifano P, Bucci C.Netherlands); mouse monoclonal anti-tubulin (T5168) from Sigma-Aldrich and rabbit polyclonal p-ROCK2 (GTX122651) from GeneTex (Irvine, CA, USA). Secondary antibodies conjugated to fluorochromes (for immunofluorescence

(8) ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in miceFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJanuary 1, 2020Wei L, Surma M, Yang Y, Tersey S, Shi J.p-MYPT-Thr696 (#ABS45) were from MilliporeSigma; UCP1 (#ab10983) from Abcam; p-ROCK2-Ser1366 from GeneTex (GTX122651). All blots were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (#ABS16) or actin (#MABT523)

(9) Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to HippocampusCerebral cortex (New York, N.Y. : 1991)July 1, 2018Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G.

(10) Phosphorylation of ARHGAP19 by CDK1 and ROCK regulates its subcellular localization and function during mitosisJournal of cell scienceMarch 2, 2018Marceaux C, Petit D, Bertoglio J, David MD.

(11) ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formationJournal of thrombosis and haemostasis : JTHOctober 1, 2017Lu DH, Hsu CC, Huang SW, Tu HJ, Huang TF, Liou HC, Liao HM, Chen CH, Fu WM, Gau SS.

(12) Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shockBritish journal of pharmacologyApril 1, 2016Tseng TL, Chen MF, Liu CH, Pang CY, Hsu YH, Lee TJ.

(13) 14-3-3τ promotes breast cancer invasion and metastasis by inhibiting RhoGDIαMolecular and cellular biologyJuly 1, 2014Xiao Y, Lin VY, Ke S, Lin GE, Lin FT, Lin WC.

(14) The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytesJournal of cell scienceJanuary 15, 2014David MD, Petit D, Bertoglio J.(clone 102) were from BD Biosciences (Franklin Lakes, NJ). Rabbit anti-phosphoSer1366 ROCK2 antibody (GTX122651) was from GeneTex (Irvine, CA). HRP-conjugated anti-mouse and anti-rabbit secondary antibodies were purchased

(15) ROCKII Ser1366 phosphorylation reflects the activation statusThe Biochemical journalApril 1, 2012Chuang HH, Yang CH, Tsay YG, Hsu CY, Tseng LM, Chang ZF, Lee HH.

(16) Perturbation of glycoprotein processing affects the neurotoxin-responsive Na+ channel in neuroblastoma cellsCarbohydrate researchJune 1, 1986Negishi M, Glick MC.

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Anti-ROCK2 (phospho Ser1366) antibody

Anti-ROCK2 (phospho Ser1366) antibody

Anti-ROCK2 (phospho Ser1366) antibody

Anti-ROCK2 (phospho Ser1366) antibody from GeneTex

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Questions and Answers

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Anti-ROCK2 (phospho Ser1366) antibody from GeneTex

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