Mitofusin-2 (D1E9) Rabbit mAb 11925S from Cell Signaling Technology

Product Specs
ItemMitofusin-2 (D1E9) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number11925S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH, Hm, Mk
ClonalityMonoclonal
TargetMitofusin-2
HostRabbit
NCBI Full Gene Namemitofusin 2
NCBI Gene AliasesCMT2A, CMT2A2, CMT2A2A, CMT2A2B, CPRP1, HMSN6A, HSG, MARF, MSL
Research AreaMetabolism
IsotypeIgG
CloneD1E9
Molecular Weight80

Questions and Answers

Can this antibody be used to study mitofusin-2 in human cells?

Yes, the Mitofusin-2 (D1E9) Rabbit mAb has been shown to recognize endogenous levels of total mitofusin-2 protein in human cells, making it suitable for applications such as Western blotting and immunocytochemistry.

Are there any specific experimental contexts where this antibody has been utilized?

The Mitofusin-2 antibody has been cited in various studies, including research on mitochondrial dynamics and mitophagy. For instance, it was used in a study demonstrating the role of mitofusin-2 in protecting against mitochondrial fragmentation during ischemia-reperfusion injury ().

What is the recommended dilution for using this antibody in Western blotting?

The recommended dilution for the Mitofusin-2 antibody in Western blotting is 1:1000, as indicated in the literature ().

Does this antibody show reactivity with non-human primate or hamster tissues?

Yes, the Mitofusin-2 (D1E9) Rabbit mAb is reactive with non-human primate and hamster tissues, in addition to human samples, making it versatile for comparative studies across species.

Cell Signaling Technology

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Phone: 877-616-CELL
Phone: 978-867-2388
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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairmentnpj AgingMarch 5, 2026Claudia Jara, Leslye Venegas-Zamora, Han S. Park-Kang, Matías Lira, Micaela Ricca, Sebastian Valenzuela, Cheril Tapia-RojasCell Signaling Technologies), mouse anti-Mfn1 (1:1000. sc-166644, Santa Cruz Biotechnology, Inc), rabbit anti-Mfn2 (1:1000, mAb 11925, Cell Signaling Technologies), rabbit anti-pDrp1 (1:1000 mAb 6319; mb 4494, Cell Signaling Technolo-gies),

(2) Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and DysfunctionCellsMarch 4, 2026Gizem Kayki Mutlu, Stephanie M. Kereliuk, Maya Hoteit, J. Kurt Chuprun, Umur Mendes, Yusuf Olgar, Walter J. KochCell Signaling Technology, Danvers, MA, USA), Mfn1 (14739; Cell Signaling Technology, Danvers, MA, USA), Mfn2 (11925; Cell Signaling Technology, Danvers, MA, USA), Opa1 (80471; Cell Signaling Technology), Pink (6946;

(3) Synergistic Neurotoxicity of environmental Cadmium and Paraquat in Parkinsonism: Unveiling the Mito-ROS/OPA1/Caspase-3/GSDME-driven Apoptosis AxisInternational Journal of Biological SciencesFebruary 18, 2026Yufei Luo, Yingying Lu, Yancheng Tang, Xuejun Zhao, Junpu Wang, Yifan Liu, Sijia Jiang, Yuyuan Zhu, Jiaqi Qi, Linlin Xing, et al.1:1000), anti-OMA1 (95473S, 1:1000), anti-OPA1 (80471S, 1:1000), anti-MFN1 (14739, 1:1000), anti-MFN2 (11925, 1:1000), anti-pS616 DRP1 (4494, 1:1000), anti-pS637 DRP1 (6319, 1:1000) and anti-GSDMD (39754S, 1:1000)

(4) Onconase Induces Apoptosis in Dabrafenib-Resistant Melanoma Cell Lines Through Dysregulation of ROS Homeostasis, Antioxidant Protein Expression, and Mitochondrial DynamicsInternational Journal of Molecular SciencesFebruary 7, 2026Carlotta Passarini, Alessia Cardile, Filippo Zuanetti, Valentina Zanrè, Raffaella Pacchiana, Adriana Celesia, Federica Danzi, Alessandra Fiore, Giovanni Gotte, Marta MenegazziCOX4 (GTX114330); c-Myc (GTX103436); (GeneTex, Irvine, CA, USA); Mitofusin-1 (#14739); Mitofusin-2 (#11925); DRP1 (#8570); OPA1 (#80471); TOM20 (#42406); GAPDH (#2118); p(Tyr605)-STAT3 (#9145); p(Ser536)P65-NF-kB

(5) Mechano-bioactive hydrogel bioelectronics for mechanical-electrical-bioenergetic conversion and glia-modulating neural regenerationNature CommunicationsNovember 23, 2025Junjie Shen, Shihao Wu, Yifan Wang, Zhiwen Yan, Tiexin Liu, Xiaodan Sun, Yun Qianhttps://www.cellsignal.cn/products/primary-antibodies/mitofusin-1-d6e2s-rabbit-mab/14739), MFN2 (Rabbit monoclonal to Mitofusin-2, cat. #11925, 1:1000, CST, the antibody was validated by the company refer to the website https://www.cellsignal.cn/products/primary-antibodies/mitofusin-2-d1e9-rabbit-mab/11925),

(6) Mitofusin 1 in mitochondrial quality control and anti-inflammatory responses in nucleus pulposus cells during disc degenerationScientific ReportsNovember 4, 2025Jae Won Shin, Young Mi Kang, Hak Sun Kim, Seong Hwan Moon, Kyung Soo Suk, Si Young Park, Byung Ho Lee, Ji Won Kwon(Mitofusin-1 (D6E2S) Rabbit mAb, #14739, 1:10000, Cell Signaling Technology Inc.), MFN2 (Mitofusin-2 (D1E9) Rabbit mAb, #11925, 1:10000, Cell Signaling Technology Inc.), NDP52 (NDP52 (D1E4A) Rabbit mAb, #60732, 1:10000, Cell Signaling Technology

(7) Mitochondrial damage drives T-cell immunometabolic paralysis after major surgeryEMBO Molecular MedicineNovember 3, 2025Simon Hirschberger, Martin B Müller, Hannah Mascolo, Melissa Seitz, Stefan Nibler, David Effinger, Kun Lu, Joscha Büch, Martin Bender, Tobias Kammerer, et al.(#ab110411, Abcam), 1:500 pDRP1, 1:500 DRP1. 1:1000 OPA1, and 1:1000 MFN2 antibodies (#3455S, #5391, #11925S, #67589, Cell Signaling Technology). As a loading control, 1:2000 beta-actin antibody (#5125, Cell Signaling Technology

(8) Kynurenic Acid Protects Against Myocardial Ischemia/Reperfusion Injury by Activating GPR35 Receptors and Preserving Mitochondrial Structure and FunctionBiomoleculesOctober 21, 2025Dóra Nógrádi-Halmi, Barbara Erdélyi-Furka, Dóra Csóré, Éva Plechl, Nóra Igaz, László Juhász, Marietta Zita Poles, Bernát Nógrádi, Roland Patai, Tamás Ferenc Polgár, et al.Protein,"Manufacturer, Catalog No.",Conditions MFN2,"CST, Cat#11925 (RRID: AB_2750893)","1:1000, 4 °C, ON" OPA1,"CST, Cat#80471 (RRID: AB_2734117)","1:1000, 4 °C, ON" DRP1,"CST,

(9) Spinocerebellar Ataxia Type 1 (SCA1) Cell Models Display Widespread Mitochondrial and Extra-Nuclear AlterationsJ Mol NeurosciOctober 2, 2025Dane Ford-Roshon, Madison Dudek, Ada Glynn, Abigale Glasman, Jaden York, Emily Lawrence, Donna Nguyen, Lindsay Shinn, Georgia Berry, Lily Kendall, et al.(EPR15581-39)",Mouse,abcam a#b283317,1:250 Anti-Mfn2,Mitofusin-2 (D1E9),Rabbit,Cell Signaling Technology #11925,1:250 Mitofilin (anti-Mic60),"Mic60 protein, MICOS complex (2E4AD5)",Mouse,abcam #ab110329,1:250 Anti-Opa1,"Optic atrophy

(10) Combining In Vivo 2-Photon Imaging with Photoactivatable Fluorescent Labeling Shows Low Rates of Mitochondrial Dynamics in Skeletal MuscleMedicine & Science in Sports & ExerciseOctober 1, 2025COLLEEN L. O’REILLY, ARIK DAVIDYAN, KATARZYNA CIZIO, STEPHEN M. DOIDGE, MATTHEW P. BUBAK, AGNIESZKA K. BOROWIK, TOMMY L. LEWIS, BENJAMIN F. MILLERCell Signaling Technology Danvers, MA; Cat# 14739, RRID:AB_2744531), MFN2 (1:10, Cell Signaling Technology Cat# 11925, RRID:AB_2750893), DRP1 (1:10, Cell Signaling Technology Cat# 8570, RRID:AB_10950498), p-DRP1 (1:25,

(11) Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male ratsMetabolic brain diseaseSeptember 24, 2025López-Cervantes M, Quintanar-Stephano A, Hérnandez-Pando R, Aguilar-Roblero R, Larriva-Sahd J, Vázquez-Martínez O, Martínez-Cabrera G, Díaz-Muñoz M.(Cell Signaling Technology Cat# 14739, RRID: AB_2744531; 1:500), and rabbit anti-MNF2 (Cell Signaling Technology Cat# 11925, RRID: AB_2750893; 1:1000) for mitochondrial fusion, rabbit anti-FIS1 (Boster Biological Technology

(12) APOE genotype-dependent differences in human astrocytic energy metabolismFrontiers in Cellular NeuroscienceSeptember 1, 2025Vanessa Budny, Chantal Bodenmann, Kathrin J. Zürcher, Maik Krüger, Sherida M. de Leeuw, Rebecca Z. Weber, Ruslan Rust, Luca Ravotto, Iván Ruminot, L. Felipe Barros, et al.antibody,Producer,Cat. No.,Dilution Anti-MFN1,Cell Signaling,14739S,1:250 Anti-MFN2,Cell Signaling,11925S,1:1000 Anti-FIS1,Abcam,ab15686,1:10.000 Anti-OPA1,Cell Signaling,67589S,1:2000 Anti-GAPDH,Meridian,H86504M,1:5000 Anti-hexokinase

(13) Precision therapy targeting CAMK2 to overcome resistance to EGFR inhibitors in FAT1 -mutated oral squamous cell carcinomaChinese Medical JournalAugust 5, 2025Yumeng Lin, Yibo Huang, Bowen Yang, You Zhang, Ning Ji, Jing Li, Yu Zhou, Ying-Qiang Shen, Qianming Chen(1:1000, 4494, CST), anti-OPA1 (1:1000, 67589, CST), anti-MFN1 (1:2000, 14739S, CST), anti-MFN2 (1:2000, 11925S, CST), anti-ATP5A1 (1:1000, 43-9800, Thermo Fisher Scientific, Waltham, MA, USA), and GAPDH (1:2000,

(14) The impact of ER(UPR) on mitochondrial integrity mediated by PDK4Cell death & diseaseJuly 29, 2025Mallick P, Maity S, Mondal R, Roy T, Meitei PM, Saxena S, Sahu BS, Chakrabarti O, Chakrabarti S.#A4737",1:1000 9 PDK3,"ABclonal, #A12480",1:500 1 0MFN2,"Cell Signaling Technology (CST), #(D1E9), 11925",1:1000 11 VDAC1,"Abcam, #15895",1:1000 12 Calnexin,"Cell Signaling Technology (CST), #(C5C9), 2679",1:1000 13

(15) Effects of mitochondrial O-GlcNAcylation in pericytes after mechanical injuryBrain ResearchJuly 15, 2025Ji Hyun Park, Dong Bin Bin Back, Shuzhen Guo, Masayoshi Tanaka, Hajime Takase, Michael J. Whalen, Ken Arai, Kazuhide Hayakawa, Eng H. Lo(1:2,000, abcam, ab46545), TOM40 (1:2,000, ThermoFisher, 18409–1-AP), MFN2 (1:2,000, Cell Signaling, 11925), OPA1 (1:2,000, Cell Signaling, 80471), MFF (1:2,000, Cell Signaling, 84580), DRP1 (1:2,000, Cell Signaling,

(16) The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signalingbioRxivJune 14, 2025Angelia D. Lockett, Aaron Snow, Pontian Adogamhe, Justin Sysol, Manas Yadav, Tendo Mubuuke, Marta T. Gomes, Todd Cook, Amanda Fisher, Micheala A. Aldred, et al.(12165s), ClpP (14181s), eIF2α (2103s), PCNA (13110s), p-Drp1 (3452s/3455s), Drp1 (5391s), mitofusin2 (11925s) anti-mouse-HRP (7076s), anti-rabbit-HRP (7074s), and Lamin-B2-HRP (24209s). MtHSP70 is from Invitrogen

(17) Metabolic traits shape responses to LSD1-directed therapy in glioblastoma tumor-initiating cellsScience AdvancesMay 23, 2025Giulia Marotta, Daniela Osti, Elena Zaccheroni, Brunella Costanza, Stefania Faletti, Adriana Marinaro, Cristina Richichi, Deborah Mesa, Simona Rodighiero, Chiara Soriani, et al.antibodies [MFN1 (1:50), Cell Signaling Technology, #14739S; MFN2 (1:100), Cell Signaling Technology, #11925S in 0.1% saponin in PBS) for 1 hour at room temperature. Coverslips were washed twice in PBS and incubated

(18) Rubicon, a Key Molecule for Oxidative Stress-Mediated DNA Damage, in Ovarian Granulosa CellsAntioxidants (Basel, Switzerland)April 15, 2025Yamada K, Ito M, Nunomura H, Nishigori T, Furuta A, Yoshida M, Yamaki A, Nakamura T, Iwase A, Shima T, et al.Protein 1 Light Chain 3 beta (LC3, 1:2000, 76446, Proteintech), MFN1 (1:4000, 14739, CST), MFN2 (1:4000, 11925, CST), mTOR (1:4000, 2972, CST), p-mTOR (1:4000, 2971, CST), p62 (1:5000, M162-3, MBL Life science),

(19) Icarisid Ⅱ modulates mitochondrial dynamics for anti-HBV activityFront PharmacolApril 1, 2025Zhengyun Liu, Haiyan Yang, Juan Wen, Dongyan Xiao, Wan Yu, Guo Luo, Qihai Gong, Huan WangFis1(Invitrogen PA5-106271; dilution: 1/1000), Mfn1(Santa Cruz #50330; dilution: 1/500) and Mfn2(CST, #11925S; dilution: 1/1000). The primary antibodies were diluted in 5% BSA-TBST-0.05% NaN3. After overnight incubation

(20) A cellular assay to determine the fusion capacity of MFN2 variants linked to Charcot-Marie-Tooth disease of type 2 ASci RepMarch 22, 2025Chloe Barsa, Julian Perrin, Claudine David, Arnaud Mourier, Manuel RojoLaboratories, 611223, dilution of 1/400) and rabbit monoclonal anti-Mitofusin-2 (D1E9) (Cell Signaling, 11925, dilution of 1/100). Incubation with the following secondary antibodies Goat anti-Mouse IgG (H + L) Alexa Fluor™ Plus 488

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9/15/2015Western Blot Analysis of MFN2 Lakshmi Reddy BolluOur laboratory is focused on studying the role of EGFR in de novo fatty acid synthesis and mitochondrial dynamics. In this experiment, we tried to determine the effect of treatments on the levels of ... Read Review

Mitofusin-2 (D1E9) Rabbit mAb

Mitofusin-2 (D1E9) Rabbit mAb from Cell Signaling Technology

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Mitofusin-2 (D1E9) Rabbit mAb from Cell Signaling Technology

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