APC2 Antibody 12301S from Cell Signaling Technology

Product Specs
ItemAPC2 Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number12301S
Quantity100 µl
ApplicationsW, IP
Conjugate/TagAPC
ReactivityH, M, R, Mk
TargetAPC2
HostRabbit
NCBI Full Gene Nameanaphase promoting complex subunit 2
NCBI Gene AliasesAPC2
ClonalityPolyclonal
Research AreaUbiquitin and Ubiquitin-like proteins
Molecular Weight100

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer CellsAdvanced ScienceJanuary 1, 2026Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, et al.(Sigma–Aldrich, F7425), GFP (Santa Cruz, sc‐9996), MYC (Santa Cruz, sc‐789), APC2 (Cell Signaling Technology, 12301), APC8 (Cell Signaling Technology, 15100), APC10 (Cell Signaling Technology, 14807), APC11 (Cell Signaling Technology

(2) The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitinationPLoS BiolDecember 8, 2025Longqiang Wang, Xiao Wu, Atanu Paul, Jun Yao, Bin WangSanta Cruz), Cyclin A (Cat#sc596, Santa Cruz), CDH1 (Invitrogen, Cat#34-2000), APC2 (Cell Signaling, Cat#12301), BARD1 (Proteintech, Cat#22964-1AP). Quantitative real-time PCR (qPCR) Total RNA was isolated from

(3) Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entryNatureOctober 2, 2025Debasish Paul, Derek L. Bolhuis, Hualong Yan, Sudipto Das, Xia Xu, Christina C. Abbate, Lisa M. M. Jenkins, Michael J. Emanuele, Thorkell Andresson, Jing Huang, et al.1:800), anti-DDK/Flag (Sigma-Aldrich, F3165, 1:1,000), p-S6 kinase (CST, 9205, 1:1,000), APC2 (CST, 12301, 1:1,000), APC6 (CST, 9499, 1:1,000), APC11 (CST, 14090, 1:1,000), S6 kinase (CST, 9202, 1:1,000), p-4EBP1

(4) PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competenceElifeApril 13, 2023Michael Xiao, Chia-Hua Wu, Graham Meek, Brian Kelly, Dara Buendia Castillo, Lyndsay EA Young, Sara Martire, Sajina Dhungel, Elizabeth McCauley, Purbita Saha, et al.1:1000 Antibody,RabbitpolyclonalAnti-APC2,Cell Signaling Technology,"Cell Signaling Technology Cat# 12301, RRID:AB_2754994",WB: 1:1000 Antibody,RabbitmonoclonalAnti-CDC20,Cell Signaling Technology,"Cell Signaling Technology

(5) CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis INature communicationsDecember 13, 2022Zhou CJ, Wang XY, Dong YH, Wang DH, Han Z, Zhang XJ, Sun QY, Carroll J, Liang CG.F7425; 1:400), rabbit anti-Securin (Cell Signaling 13445; 1:200), rabbit anti-APC2 (Cell Signaling 12301S; 1:200), rabbit anti-APC11 (Abcam ab154546; 1:200), rabbit anti-UbcH5/Ubc4 (Proteintech 28328-AP; 1:200),

(6) Impaired Cdc20 signaling promotes senescence in normal cells and apoptosis in non-small cell lung cancer cellsThe Journal of biological chemistryOctober 1, 2022Volonte D, Sedorovitz M, Galbiati F.sources: anti-Cdc20 (14866), anti-securin (13445), anti-phospho-p53 (9284), anti-γ-H2A.X (9718), Apc2 (12301), and anti-Rad21 (4321) IgGs were from Cell Signaling Technologies; anti-β-actin (mAb C4), anti-p21

(7) Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesisNature communicationsDecember 2, 2021Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, et al.Biological Laboratories, D058-3, clone FK2, 1 μg/ml), anti-ANAPC2 rabbit pAb (Cell Signaling Technology, 12301, 1:500), anti-ANAPC11 rabbit mAb (Cell Signaling Technology, 14090, clone D1EQ7, 1:500), anti-CDC20

(8) CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65EMBO reportsSeptember 6, 2021Du Y, Zhang M, Liu X, Li Z, Hu M, Tian Y, Lv L, Zhang X, Liu Y, Zhang P, et al.66005‐1‐Ig), H3 (Cell Signaling Technology, 2650S), CDC20 (Abcam, ab183479), APC2 (Cell Signaling Technology, 12301S), APC11 (Cell Signaling Technology, 14090), Myc‐tag (Cell Signaling Technology, 2276), Flag‐tag (Cell Signaling Technology

(9) Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylationCell reportsMarch 30, 2021Yatskevich S, Kroonen JS, Alfieri C, Tischer T, Howes AC, Clijsters L, Yang J, Zhang Z, Yan K, Vertegaal ACO, et al.monoclonal to APC3,Cell Signaling Technology,12530s Rabbit polyclonal to APC2,Cell Signaling Technology,12301s HRP conjugated sheep anti-mouse,GE Healthcare,NXA931V HRP conjugated donkey anti-rabbit,ThermoFisher,SA1-200 HRP

(10) The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug ResistanceCell reportsSeptember 8, 2020Zhang S, Shen Y, Li H, Bi C, Sun Y, Xiong X, Wei W, Sun Y.monoclonal anti-SAG,"home-made (Jia et al., 2010)",N/A Rabbit Polyclonal anti-APC2,Cell Signaling,Cat# 12301s; RRID:AB_2619505 Rabbit monoclonal anti-APC11,Cell Signaling,Cat# 14090s; RRID:AB_485228 Rabbit monoclonal

(11) RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exitOncotargetJune 23, 2020Hee-Don Chae, Ritika Dutta, Bruce Tiu, Fieke W. Hoff, Benedetta Accordi, Valentina Serafin, Minyoung Youn, Min Huang, Nathan Sumarsono, Kara L. Davis, et al.anti-p-RPS6 (S235/236) (2211), anti-p-CDC2 (Y15), anti-RB (4H1), anti-p-RB (S780) (D59B7), anti-APC2 (12301, Cell Signaling Technology, Danvers, MA, USA); anti-MPM2 (Millipore); anti-CDC20 (A301, Bethyl Lab).

(12) Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly CheckpointCell reportsNovember 27, 2018Wild T, Budzowska M, Hellmuth S, Eibes S, Karemore G, Barisic M, Stemmann O, Choudhary C.-APC1 (D1E9D) Rabbit mAb,Cell Signaling Technology,Cat# 13329 Anti-APC2 Antibody,Cell Signaling Technology,Cat# 12301 Anti-APC7 Antibody,Bethyl laboratories,Cat# A302-551A; RRID: AB_1998911 Anti-APC8 (D5O2D) Rabbit mAb,Cell Signaling Technology

(13) Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrestThe EMBO journalSeptember 3, 2018Allan LA, Skowyra A, Rogers KI, Zeller D, Clarke PR.Laboratories; APC8 (1/1,000, A301‐181A) and Fbw7 (A301‐720A‐1), Bethyl Laboratories; APC2 (1/1,000, 12301S) and cyclin E (1/1,000, 4129S), Cell Signaling Technologies; MPM2 (1/1,000, 05‐368), Millipore; APC10

(14) Conditional control of fluorescent protein degradation by an auxin-dependent nanobodyNature communicationsAugust 17, 2018Daniel K, Icha J, Horenburg C, Müller D, Norden C, Mansfeld J.Bethyl laboratories, A301–653A, RRID:AB_1210875), ANAPC2 (rabbit monoclonal antibody,1:1000, Cell Signaling, 12301), ANAPC5 (rabbit polyclonal antibody, 1:1000, Bethyl laboratories, A301–026A, RRID:AB_2227119), ANAPC6

(15) USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal InstabilityCell reportsApril 17, 2018Skowyra A, Allan LA, Saurin AT, Clarke PR.611269) (both from BD Biosciences); BubR1 (1/2,500, A300-386A; Bethyl Laboratories); APC2 (1/1,000, 12301S; Cell Signaling Technology); MPM2 (1/1,000, 05-368; Millipore); survivin (1/1,000, 2235; ProSci); USP9X

(16) APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase ActivityCurrent BiologyMay 22, 2017Ahmed Rattani et al.4539), Cdc25B (1:250, Cell Signaling, 9525), Cdh1 (1:200, Abcam, ab3242), Apc2 (1:250, Cell Signaling, 12301) or actin (1:500, Abcam, ab3280) at 4°C for 12 hr. Membranes were washed thrice for 10 min each in PBT

(17) SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAsThe EMBO journalNovember 18, 2014van der Lelij P, Stocsits RR, Ladurner R, Petzold G, Kreidl E, Koch B, Schmitz J, Neumann B, Ellenberg J, Peters JM.ID 782M), mouse anti-myc (myc (9E10), Peters laboratory ID A668), rabbit anti-APC2 (Cell Signalling 12301), rabbit anti-sororin (sororin 1809M Peters laboratory ID 953), rabbit anti-SMC1 (Bethyl A300-055A),

(18) The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assemblyJournal of cell scienceJanuary 1, 0001"Tischer T, Yang J, Barford D."(Cell Signaling Technology, 9499; 1:1000), APC3 (Cell Signaling Technology, 12530; 1:1000), APC2 (Cell Signaling Technology, 12301; 1:1000), CDH1 (Abcam, ab89535; 1:1000), BubR1 (Abcam, ab54894; 1:500), Mad2 (Abcam, ab10691; 1:1000),

(19) A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphaseEMBO reportsJanuary 1, 0001"Alfieri C, Tischer T, Barford D."Apc4 antibody (Abcam, ab72149), detection of Apc2 with the rabbit monoclonal Apc2 antibody (Cell Signaling, 12301) and HRP‐conjugated donkey anti‐rabbit antibody (Thermo Fischer, SA1‐200). Primary antibodies were used

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APC2 Antibody

APC2 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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APC2 Antibody from Cell Signaling Technology

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