RCAS1 (D2B6N) XP ® Rabbit mAb 12290S from Cell Signaling Technology

Product Specs
ItemRCAS1 (D2B6N) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number12290S
Quantity100 µl
ApplicationsW, IP, IF-IC, FC-FP
ReactivityH, M, R
ClonalityMonoclonal
TargetRCAS1
HostRabbit
NCBI Full Gene Nameestrogen receptor binding site associated antigen 9
NCBI Gene AliasesEB9, PDAF
Research AreaProtein Folding and Trafficking
CloneD2B6N
Molecular Weight32

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumorsCell Reports MedicineApril 21, 2026Yizhi Cao, Caleb Cheng, Yitong Yin, Sarah N. Yee, Yang Zheng, Somnath Mahapatra, Radha Paturu, Andrej Coleski, Shannon VanAken, Fan Yang, et al.,Cell Signaling Technology,Cat# 12238; RRID: AB_2688013 RCAS1 (D2B6N) Rabbit mAb,Cell Signaling Technology,Cat# 12290; RRID: AB_2736985 PEX5 (D7V4D) Rabbit mAb,Cell Signaling Technology,Cat# 83020; RRID: AB_2800006 Anti-SDHB

(2) Chiral methionine oxidation reagents reveal stereospecific proteome modificationsbioRxivMarch 30, 2026Angel Gonzalez-Valero, Annika C. S. Page, Jayde M. Bertoch, Fadi Alsarhan, Jaehee Kim, Amr A. Alazali, Ritwik R. Srinivas, Xiao Xie, Audrey G. Reeves, Kacper Skakuj, et al.Antibodies used were rabbit anti-VDAC (CST; 4661), rabbit anti-PDI (CST; 3501), rabbit anti-RCAS1 (CST; 12290), rabbit anti-GAPDH (CST; 5714), and rabbit anti-Histone H3 (CST; 4499). All antibodies were diluted

(3) Hsd17b7 undergoes dynamic subcellular localization during Neuro2a differentiationFrontiers in Molecular NeuroscienceJanuary 15, 2026Matthew Bispo, Macey Pennay, Joe C. Brague, Ashley M. DriverCell Signaling) primary antibodies. The Golgi apparatus was targeted with anti-RCAS1 primary antibody (12290, Cell Signaling) while dendrites were targeted with anti-MAP2 (4542, Cell Signaling) primary antibody.

(4) Variant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organizationiScienceDecember 1, 2025Masaki Hosogane, Sue-yi Siao, Atsushi Hatano, Xiaoxin Huang, Yuichi Shichino, Yasuaki Watanabe, Shintaro Iwasaki, Masaki Matsumoto, Keiko NakayamaRRID:AB_1268721 SEC61B,Cell Signaling Technology,Cat# 14648; RRID:AB_2798555 RCAS1,Cell Signaling Technology,Cat# 12290; RRID:AB_2736985 HSP90,BD Biosciences,Cat# 610418; RRID:AB_397798 GAPDH,Santa Cruz Biotechnology,Cat#

(5) Programmed cell revival from imminent cell death enhances tissue repair and regenerationThe EMBO JournalAugust 21, 2025Kollori Dhar, Kautilya Kumar Jena, Subhash Mehto, Rinku Sahu, Krushna C Murmu, Atharva Anand Mahajan, Sibaram Behera, Ravi Kiran Putchala, Reuben Jacob Mathew, Ramyasingh Bal, et al.,Cell Signaling Technology,Cat#9367; RRID:AB_1904103 RCAS1 (D2B6N) (Rabbit-mAb),Cell Signaling Technology,Cat#12290; RRID:AB_2736985 Anti-beta Tubulin (Rabbit-pAb),Abcam,Cat#ab6046; RRID:AB_2210370 LC3b (Rabbit-pAb),MBL,Cat#PM036;

(6) TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelinationProceedings of the National Academy of SciencesJuly 29, 2025Julia Halford, Amanda J. Senatore, Sage Berryman, Antonio Muñoz, Destinee Semidey, Ryan A. Doan, Adam M. Coombs, Brandon Noimany, Katie Emberley, Ben Emery, et al.in blocking solution: rabbit anti-LAMP1 1:400 (CST, cat# 9091S), rabbit anti-RCAS1 1:200 (CST, cat# 12290S), rabbit anti-PDI 1:100 (CST, cat# 3501S). Labeled cells were washed and incubated with secondary antibody

(7) UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironmentCell Death DisJuly 22, 2025Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David J. MacLean, Nicole Machado, Gonzalo Rodriguez-Berriguete, Lolita Singh, Geoff S. Higgins, Ester M. Hammond, et al.(Cell Signalling; 5318), PDI (Cell Signalling, 3501), EEA1 (Cell Signalling, 3288), and RCAS1 (Cell Signalling, 12290). Alexa Fluor 594 donkey anti-rabbit IgG (Thermo Fisher Scientific, A32754), Alexa Fluor 488 donkey

(8) Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ effluxNat CommunJune 5, 2025Ran Chen, Bin Liu, Dawid Jaślan, Lucija Kucej, Veronika Kudrina, Belinda Warnke, Yvonne E. Klingl, Arnas Petrauskas, Sandra Prat Castro, Kenji Maeda, et al.potassium ATPase (ab76020) were purchased from Abcam; anti-cofilin (3318S), anti-GAPDH (5174S), anti-RCAS1 (12290), and anti-VDAC (12454S) from Cell Signaling Technology; anti-LAMP2 (L0668-200UL) from Sigma Aldrich;

(9) Activation of lysosomal iron triggers ferroptosis in cancerNatureJune 1, 2025Cañeque T, Baron L, Müller S, Carmona A, Colombeau L, Versini A, Solier S, Gaillet C, Sindikubwabo F, Sampaio JL, et al.MHCII-APC/Cyanine7 (BioLegend, 107628, clone M5/114.12.2, lot B370049, FCy, 1:100, Ms); RCAS1 (Cell Signaling, 12290S, clone D2B6N, lot 1, FI, 1:200, Hu, WB, 1:1,000, Hu); SLC7A11/xCT (Cell Signaling, 12691S, clone D2M7A,

(10) Engineered depalmitoylases enable selective manipulation of protein localization and functionNat CommunApril 13, 2025Srinidhi Jayaraman, Audrey Kochiss, Thy-Lan Alcalay, Pedro J. Del Rivero Morfin, Manu Ben-Johnyfollows: for ER, Cytopainter (1:1000; AbCaM catalog number ab139482); for Golgi, RCAS (Cell Signaling, #12290.1:100); for PM, Cell Mask (ThermoFisher: C10046, 1:2500); for early endosome, EEA1 (Cell signaling,

(11) RNF13 variants L311S and L312P associated with developmental epileptic encephalopathy alter dendritic organization in hippocampal neuronsIBRO Neurosci RepApril 9, 2025Valérie C. Cabana, Marc P. LussierDiego, CA, USA, Cat# 901502, RRID:AB_2565007), Rabbit anti-RCAS1 (1:250, Cell Signaling Technology, Cat# 12290, RRID:AB_2736985), Rabbit anti-MAP2 (1:100, Cell Signaling Technology, Cat #4542, RRID:AB_10693782),

(12) SH3KBP1 promotes skeletal myofiber formation and functionality through ER/SR architecture integrityEMBO ReportsMarch 10, 2025Alexandre Guiraud, Nathalie Couturier, Emilie Christin, Léa Castellano, Marine Daura, Carole Kretz-Remy, Alexandre Janin, Alireza Ghasemizadeh, Peggy del Carmine, Laloe Monteiro, et al.Bitoun,N/A Antibodies,Antibodies,Antibodies Anti-SH3KBP1,Sigma-Aldrich,HPA003355 Anti-SH3KBP1,Santa-Cruz,sc-48746 Anti-myosin heavy chain,DSHB,MF20 Anti-DHPR-a,DSHB,IIID5E1 Anti-RCAS1,Cell Signaling,#12290 Anti-Erp72,Cell Signaling,#5033 Anti-calnexin,Cell Signaling,#2679 Anti-LC3-II/LC3-I,Sigma-Aldrich,L7543 Anti-alpha

(13) S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the GolgieLifeSeptember 12, 2024Williams DM, Peden AA.monoclonal STX5,Synaptic SystemsCat# 110 053,RRID:AB_887800,Rabbit polyclonal RCAS1,Cell Signalling Tech Cat# 12290,RRID:AB_2736985,Rabbit monoclonal EEA1,BD BiosciencesCat# 610457,RRID:AB_397830,Mouse monoclonal GM130,BD

(14) Excitotoxic glutamate levels cause the secretion of resident endoplasmic reticulum proteinsJournal of neurochemistrySeptember 1, 2024Dossat AM, Trychta KA, Glotfelty EJ, Hinkle JJ, Fortuno LV, Gore LN, Richie CT, Harvey BK.DAPI for 8 min at 1:1000. Primary antibodies: rabbit anti-RCAS1 (1:250, Cell Signaling Technology Cat# 12290, RRID:AB_2736985), mouse anti-Flag (1:1500; Sigma-Aldrich Cat# F1804, RRID:AB_262044). Secondary antibodies

(15) Cancer stem cells release interleukin-33 within large oncosomes to promote immunosuppressive differentiation of macrophage precursorsImmunityAugust 1, 2024Hannah L. Erickson, Sachiko Taniguchi, Anish Raman, Justin J. Leitenberger, Sanjay V. Malhotra, Naoki Oshimori,Cell Signaling Technology,Cat#3501; Clone: C81H6 Rabbit monoclonal anti-RCAS,Cell Signaling Technology,Cat#12290; Clone: D2B6N Rabbit monoclonal anti-AIF,Cell Signaling Technology,Cat#5318; Clone: D39D2 Rabbit monoclonal

(16) Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPSFrontiers in Cellular NeuroscienceMarch 25, 2024Ruiqi Chen, Lirui Xie, Yang Fan, Xiangmei Hua, Chang Y. Chungdisulfide isomerase (PDI; #3501), receptor binding cancer antigen expressed on SiSo cells (RCAS1; #12290), lysosome-associated membrane protein 1 (LAMP1; #51774) primary antibodies (Cell Signaling Technology,

(17) Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cellsCells & DevelopmentMarch 1, 2024Shaohe Wang, Kazue Matsumoto, Madison M. Mehlferber, Guofeng Zhang, Maria A. Aronova, Kenneth M. Yamada2 μg/mL; anti-PDI (Cell Signaling Technology, 3501), 1:100; anti-RCAS1 (Cell Signaling Technology, 12290), 1:200; anti-AIF (Cell Signaling Technology, 5318), 1:400; anti-RAB6A (Thermo Fisher, PA5–22127), 2

(18) A retrotransposon-derived DNA zip code internalizes myeloma cells through Clathrin-Rab5a-mediated endocytosisFrontiers in OncologyFebruary 23, 2024Pavan Kumar Puvvula, Lourdes Martinez-Medina, Munevver Cinar, Lei Feng, Andrey Pisarev, Anthony Johnson, Leon Bernal-Mizrachi(Cell Signaling, 2679), ERp72 (Cell Signaling, 5033), PDI (Cell Signaling, 3501), RCAS1 (Cell Signaling, 12290), Syntaxin-6 (Cell Signaling, 2869), Anti-rabbit IgG-HRP (Cell Signaling, 7074), Anti-mouse IgG-HRP

(19) Fatty acid synthesis suppresses dietary polyunsaturated fatty acid useNature communicationsJanuary 2, 2024Worthmann A, Ridder J, Piel SYL, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer AW, Adak S, Sundd M, et al.(abcam; Ab4729; 1:1000 dilution), P-Ser (Sigma-Aldrich; AB1603; 1:1000 dilution), Rcas (Cell Signaling; #12290; 1:1000 dilution), LDHA (Cell Signaling; 2012; 1:1000 dilution), Malonyl-Lys (Cell Signaling; #14942;

(20) The role of lysosomes as intermediates in betacoronavirus PHEV egress from nerve cellsJournal of VirologyDecember 21, 2023Zhenzhen Wang, Wenqi He, Caili Li, Yuzhu Chen, Zi Li, Yubo Jiao, Jing Zhang, Junchao Shi, Gaili Wang, Jiyu Guan, et al.anti-ARL8B antibody (Affinity Biosciences, DF12350), anti-RCAS1 antibody (Cell Signaling Technology, 12290), and anti-ERp72 antibody (Proteintech, 14712–1-AP). The secondary antibodies used for western blotting

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(1)

5/15/2020Good Golgi Marker; However, Lower Resolution than Other Markers Mark EExcellent marker for the golgi when used at 1:500, didn't require any additional titration.

RCAS1 (D2B6N) XP ® Rabbit mAb

RCAS1 (D2B6N) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (49)

Reviews

RCAS1 (D2B6N) XP ® Rabbit mAb from Cell Signaling Technology

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