MyBioSource.com's PDGFR beta Antibody is a Mouse monoclonal antibody. The PDGFR beta Antibody was generated using CD140b, JTK12, PDGFR beta, PDGFR1, and PDGFRB as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: ELISA, and Western Blot.
Description
Background: Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRbeta or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor alpha (PDGFRalpha) and PDGF receptor beta (PDGFRbeta). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia