MyBioSource.com's CD18 Antibody is a Mouse monoclonal antibody. The CD18 Antibody was generated using Integrin beta 2, and ITGB2 as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: ELISA, and Immunofluorescence.
Description
Background: CD18, also known as ITGB2 (integrin beta chain beta 2). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. CD18 is expressed by most leucocytes. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene