CD11b/c Antibody - BSA Free NB110-40766 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemCD11b/c Antibody - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $419.00Supplier Page View Company Product Page
Catalog NumberNB110-40766
NCBI Gene AliasesMAC1A, CR3A, MAC-1, MO1A, SLEB6, CD11B
ImmunogenA synthetic peptide made to an internal region (within residues 500-600) of the mouse CD11 (b/c) protein. [Swiss-Prot: P05555]
Concentration1.0 mg/ml
Quantity0.1 ml (also 0.025 ml)
ApplicationsIF/IHC,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence
HostRabbit
ReactivityHuman,Mouse,Rat
Conjugate/TagUnconjugated
TargetCD11b/c
FormatPBS + 30% Glycerol
NCBI Full Gene Nameintegrin subunit alpha M
ClonalityPolyclonal
PurityImmunogen affinity purified
Molecular Weight160 kDa
Research AreaBreast Cancer, Cancer, Cellular Markers, Glia Markers, Immunology, Microglia Markers, Neuronal Cell Markers, Neuroscience, Signal Transduction
IsotypeIgG
Antibody TypePrimary Antibodies
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Sizes Available: 0.1 ml (also 0.025 ml)

Questions and Answers

Can this antibody be used to study microglial activation in the context of HIV research?

Yes, the CD11b/c antibody has been utilized in studies investigating the interaction between microglia and neurons in HIV research. For instance, it was employed to assess microglial activation in co-culture systems involving HIV-infected microglial cells and healthy neurons, highlighting its role in modulating HIV expression and neurotoxicity ().

Is this antibody effective for immunohistochemistry applications in mouse models?

The CD11b/c antibody has been shown to work effectively in immunohistochemistry applications. In one study, it was used to visualize microglial cells in mouse brain sections, demonstrating its utility in assessing microglial presence and activation in various experimental settings ().

What species can this antibody react with, and how does that impact its use in experiments?

This antibody is reactive with mouse, human, and rat species. This broad reactivity allows researchers to use it in comparative studies across different model organisms, facilitating investigations into microglial function and immune responses in both human and animal models ().

Has this antibody been cited in studies related to inflammation and immune response?

Yes, the CD11b/c antibody has been cited in multiple studies focusing on inflammation and immune responses. For example, it was used to analyze immune cell infiltration and cytokine production in models of rheumatoid arthritis, indicating its relevance in studies of inflammatory processes ().

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapyThe Journal of clinical investigationMay 2, 2022Salman S, Meyers DJ, Wicks EE, Lee SN, Datan E, Thomas AM, Anders NM, Hwang Y, Lyu Y, Yang Y, et al.

(2) Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in miceBiochemical pharmacologyMay 1, 2022Pouso-Vázquez E, Bai X, Batallé G, Roch G, Pol O.

(3) Therapeutic effect of adipose stromal vascular fraction spheroids for partial bladder outlet obstruction induced underactive bladderStem cell research & therapyFebruary 9, 2022Liu J, Zhou L, Zhao F, Zhou C, Yang T, Xu Z, Wang X, Xu L, Xu Z, Ge Y, et al.

(4) The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1Cancer cellJanuary 10, 2022Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, Yin X, Saito Y, Fan H, Li P, et al.used: HRH1 (LS-C331459, LifeSpan BioSciences), VISTA (54979, Cell Signaling Technology) and CD11b (NB110-40766, Novus Biologicals). Enzyme-linked immunosorbent assay (ELISA) The levels of histamine in cell culture

(5) Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritisFrontiers in immunologyJanuary 1, 2022Garcia-Hernandez ML, Rangel-Moreno J, Garcia-Castaneda M, Kenney HM, Paine A, Thullen M, Anandarajah AP, Schwarz EM, Dirksen RT, Ritchlin CT.(SP-2001, Vector Laboratories, Burlingame, CA) followed by incubation with biotin-conjugated CD11b/c (NB110-40766, Novus biological, CO), CD3e (clone M-20; Santa Cruz Biotechnology, Dallas, Tx), biotin-conjugated TNF

(6) Modulation of Sirt1 and FoxO1 on Hypothalamic Leptin-Mediated Sympathetic Activation and Inflammation in Diet-Induced Obese RatsJournal of the American Heart AssociationJuly 20, 2021Liu X, Zheng H.incubated with macrophage/microglia cell marker CD11b/c antibody conjugated with DyLight 488 (1:500, NB110‐40766, Novus Biologicals, Centennial, CO) overnight at 4°C. After washing, the sections were mounted on the

(7) The Antinociceptive, Antioxidant and Anti-Inflammatory Effects of 5-Fluoro-2-Oxindole during Inflammatory PainAntioxidants (Basel, Switzerland)December 9, 2020Redondo A, Riego G, Pol O.

(8) BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy EfficacyCell reportsAugust 25, 2020Samanta D, Huang TY, Shah R, Yang Y, Pan F, Semenza GL.

(9) Cross-talk between microglia and neurons regulates HIV latencyPLoS pathogensDecember 1, 2019Alvarez-Carbonell D, Ye F, Ramanath N, Garcia-Mesa Y, Knapp PE, Hauser KF, Karn J.(Cell Signaling Technology, #4542), antiCXCR3 rabbit (Novus Biologicals, #NB10056404), anti-CD11b/c (Novus Biologicals, #NB11040766), anti-GAD 65/67 rabbit (Millipore, #AB1511), anti-dopamine transporter (DAT) (Millipore, #MAB369),

(10) Analgesic and Antidepressant Effects of Oltipraz on Neuropathic Pain in Mice by Modulating Microglial ActivationJournal of clinical medicineJune 21, 2019Díaz AF, Polo S, Gallardo N, Leánez S, Pol O.Cambridge, U.K.), total IκBα (1:200; 4812, Cell Signaling Technology, Danvers, MA, USA), CD11b/c (1:200, NB110-40766, Novus Biologic, Litton, CO, USA), or glyceraldehyde-3-phosphate dehydrogenase antibody (GAPDH) (1:5000;

(11) The Effects of Cobalt Protoporphyrin IX and Tricarbonyldichlororuthenium (II) Dimer Treatments and Its Interaction with Nitric Oxide in the Locus Coeruleus of Mice with Peripheral InflammationInternational journal of molecular sciencesMay 5, 2019Moreno P, Cazuza RA, Mendes-Gomes J, Díaz AF, Polo S, Leánez S, Leite-Panissi CRA, Pol O.

(12) Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q AntibodiesNeuronDecember 19, 2018Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, et al.

(13) Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunctionMolecular metabolismOctober 1, 2018Cruz VH, Arner EN, Wynne KW, Scherer PE, Brekken RA.analysis were blocked with 20% aquablock and incubated with rabbit anti-cd11b/c (Novus Biologicals, NB110-40766) in blocking solution (5% BSA in TBS with 0.05% tween) at 4 °C overnight. Horseradish peroxidase–conjugated

(14) Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4Nature communicationsFebruary 21, 2018Lu N, Li Y, Zhang Z, Xing J, Sun Y, Yao S, Chen L.anti-mIgG antibody (A-11020, 1:500 dilution) from Thermo Fisher Scientific. Meanwhile, anti-CD11c Ab (NB110-40766, 1;200 dilution) from Novus Biologicals and Alexa Fluor 488-labeled Goat Anti-Rabbit IgG H&L Abs (ab150077,

(15) Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic painBiochemical pharmacologyFebruary 1, 2018Riego G, Redondo A, Leánez S, Pol O.

(16) Sulforaphane Inhibited the Nociceptive Responses, Anxiety- and Depressive-Like Behaviors Associated With Neuropathic Pain and Improved the Anti-allodynic Effects of Morphine in MiceFrontiers in pharmacologyJanuary 1, 2018Ferreira-Chamorro P, Redondo A, Riego G, Leánez S, Pol O.

(17) Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer painInternational journal of cancerJanuary 15, 2017Ding Z, Xu W, Zhang J, Zou W, Guo Q, Huang C, Liu C, Zhong T, Zhang JM, Song Z.

(18) The Induction of Heme Oxygenase 1 Decreases Painful Diabetic Neuropathy and Enhances the Antinociceptive Effects of Morphine in Diabetic MicePloS oneJanuary 1, 2016Castany S, Carcolé M, Leánez S, Pol O.

(19) Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted TherapyCancer researchNovember 15, 2015Biktasova AK, Dudimah DF, Uzhachenko RV, Park K, Akhter A, Arasada RR, Evans JV, Novitskiy SV, Tchekneva EE, Carbone DP, et al.

(20) Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinomaCancer researchApril 15, 2015Massó-Vallés D, Jauset T, Serrano E, Sodir NM, Pedersen K, Affara NI, Whitfield JR, Beaulieu ME, Evan GI, Elias L, et al.

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