STEP (23E5) Antibody sc-23892 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSTEP (23E5) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-23892
Antibody TypePrimary Antibodies
Clone23E5
Quantity200 µg/ml
Reactivitymouse, rat, human
Conjugate/TagUnconjugated
ApplicationsWB, IP, IF
ClonalityMonoclonal
TargetSTEP46
NCBI Full Gene Nameprotein tyrosine phosphatase, non-receptor type 5, protein tyrosine phosphatase non-receptor type 5
NCBI Gene AliasesSTEP, STEP61, PTPSTEP, Step
IsotypeIgG2b
FormatPurified
Hostmouse

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Activity of Corticotropin-Releasing Factor Neurons in the Bed Nucleus of the Stria Terminalis Reduces Anxiety-Potentiated Startle in Female Rats in an Estrous Phase–Dependent MannerBiological PsychiatryFebruary 15, 2026Rachel Chudoba, Joanna DabrowskaRESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies Mouse Striatal enriched protein tyrosine phosphatase (STEP) antibody,"Santa Cruz Antibodies, sc-23892",RRID:AB_2173549 Goat anti-mouse IgG Alexa 488 secondary antibody,"ThermoFisher Scientific, A11029",RRID:AB_2534088 Bacterial

(2) Lack of striatal-enriched protein tyrosine phosphatase affected the serotonin system, behavior, and brain morphology in miceFrontiers in PsychiatryJanuary 14, 2026Vitalii Moskaliuk, Polina Komleva, Nikita Khotskin, Alla Arefieva, Oleg Shevelev, Alexey Korablev, Irina Serova, Nariman Battulin, Alexander Kulikov, Vladimir Naumenko, et al.is the translation start of the STEP46 isoform and the antigen sequence for the anti-STEP antibody (sc-23892, Santa Cruz Biotechnology, USA). The orange highlighted sequence is absent in the Ptpn5 KO mice. Rectangle

(3) D1 / D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2The FEBS JournalSeptember 22, 2025Kevin Chua, Yee Song Chong, Sreedharan SajikumarCell Signaling Technology), rabbit anti‐p44/42 MAPK (1 : 1000, #9102; Cell Signaling Technology), mouse anti‐STEP (1 : 200, sc‐23892; Santa Cruz Biotechnology, Dallas, TX, USA) and mouse anti‐GAPDH (1 : 3000, #97166; Cell Signaling Technology),

(4) Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousalCell ReportsJune 24, 2025Walter Francesconi, Valentina Olivera-Pasilio, Fulvia Berton, Susan L. Olson, Rachel Chudoba, Lorena M. Monroy, Quirin Krabichler, Valery Grinevich, Joanna Dabrowskaprotein tyrosine phosphatase (STEP), using anti-STEP primary antibody (mouse, dilution 1:500, Santa Cruz sc-23892, RRID:AB_2173549)33 and protein kinase C delta (PKCδ), with anti-PKCδ primary antibody (mouse, dilution

(5) On an association between fear-induced aggression and striatal-enriched protein tyrosine phosphatase (STEP) in the brain of Norway ratsBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieMarch 1, 2022Moskaliuk VS, Kozhemyakina RV, Bazovkina DV, Terenina E, Khomenko TM, Volcho KP, Salakhutdinov NF, Kulikov AV, Naumenko VS, Kulikova E.

(6) Extended amygdala circuits are differentially activated by context fear conditioning in male and female ratsNeurobiology of Learning and MemoryApril 1, 2021Louise Urien, Nicole Stein, Abigail Ryckman, Lindsey Bell, Elizabeth P. Bauerguinea pig anti-CRF (1:2000; Peninsula Labs, T-5007) and monoclonal mouse anti-STEP (1:500, Santa Cruz, sc-23892). The antibody directed against ARC has been verified for specificity and widely used to label neurons

(7) Huntington's disease brain-derived small RNAs recapitulate associated neuropathology in miceActa neuropathologicaApril 1, 2021Creus-Muncunill J, Guisado-Corcoll A, Venturi V, Pantano L, Escaramís G, García de Herreros M, Solaguren-Beascoa M, Gámez-Valero A, Navarrete C, Masana M, et al.

(8) Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2eLifeApril 20, 2020Dasgupta A, Lim YJ, Kumar K, Baby N, Pang KLK, Benoy A, Behnisch T, Sajikumar S.anti-p-P42/44 MAPK or p-ERK1/2 (1:500;: 4370S, Cell Signaling Technology, USA), mouse anti-STEP (1:500; # sc-23892, Santa Cruz Biotechnology) and mouse anti-tubulin monoclonal antibody (# T9026, Sigma-Aldrich, St. Louis,

(9) The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory DeclineCurrent biology : CBApril 2, 2018Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, et al.

(10) Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP₆₁Molecular neurobiologyApril 1, 2018Xu J, Kurup P, Nairn AC, Lombroso PJ.

(11) Chelerythrine promotes Ca(2+)-dependent calpain activation in neuronal cells in a PKC-independent mannerBiochimica et biophysica acta. General subjectsApril 1, 2017Saavedra A, Fernández-García S, Cases S, Puigdellívol M, Alcalá-Vida R, Martín-Flores N, Alberch J, Ginés S, Malagelada C, Pérez-Navarro E.

(12) Amygdala-Dependent Molecular Mechanisms of the Tac2 Pathway in Fear LearningNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyOctober 1, 2016Andero R, Daniel S, Guo JD, Bruner RC, Seth S, Marvar PJ, Rainnie D, Ressler KJ.mouse monoclonal anti-PKCδ (1 : 500, 610398, BD Biosciences), mouse monoclonal anti-STEP (1 : 500, SC-23892, Santa Cruz), rabbit polyclonal antiNk3R (1 : 2000 in Tac2–GFP mouse and 1 : 1000 in WT mouse, (Griffond

(13) STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and toleranceExperimental & molecular medicineFebruary 26, 2016Kim YJ, Kang Y, Park HY, Lee JR, Yu DY, Murata T, Gondo Y, Hwang JH, Kim YH, Lee CH, et al.

(14) Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibitionPainFebruary 1, 2016Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, et al.

(15) Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic PlasticityNeural plasticityJanuary 1, 2016Jang SS, Royston SE, Lee G, Wang S, Chung HJ.hyperexcitability. 2. Material and Methods 2.1. Materials. Antibodies used include anti-STEP61 (catalogue SC-23892, Santa Cruz), anti-GluN2B (#14544, Cell Neural Plasticity Signaling), anti-ERK1/2 (SC-154, Santa Cruz),

(16) Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus--linking NMDA receptors and the reelin pathwayExperimental neurologyNovember 1, 2014Mota SI, Ferreira IL, Valero J, Ferreiro E, Carvalho AL, Oliveira CR, Rego AC.

(17) Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse modelJournal of neurochemistryJuly 1, 2014Gladding CM, Fan J, Zhang LY, Wang L, Xu J, Li EH, Lombroso PJ, Raymond LA.(S5768, Sigma, 1:1000), mouse anti-PSD-95 (MA1-045, Affinity BioReagents, 1:500), mouse anti-STEP (23E5; sc-23892, Santa Cruz, 1:500), rabbit anti-phosphorylated STEP (pSTEP61 and pSTEP46; AB2208, Millipore, 1:200),

(18) The NMDA receptor subunit GluN3A protects against 3-nitroproprionic-induced striatal lesions via inhibition of calpain activationNeurobiology of diseaseDecember 1, 2012Martínez-Turrillas R, Puerta E, Chowdhury D, Marco S, Watanabe M, Aguirre N, Pérez-Otaño I.

(19) Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicityThe Journal of neuroscience : the official journal of the Society for NeuroscienceJune 1, 2011Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas JJ, Lombroso PJ, Alberch J, Pérez-Navarro E.

(20) Dual alteration of limbic dopamine D1 receptor-mediated signalling and the Akt/GSK3 pathway in dopamine D3 receptor mutants during the development of methamphetamine sensitizationJournal of neurochemistryJanuary 1, 2007Chen PC, Lao CL, Chen JC.

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STEP (23E5) Antibody

STEP (23E5) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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STEP (23E5) Antibody from Santa Cruz Biotechnology, Inc.

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