Notch-1 Antibody AF1057 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemNotch-1 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $479.00Supplier Page View Company Product Page
Catalog NumberAF1057
NCBI Gene AliaseshN1, AOVD1, NOTCH, AOS5, TAN1
ApplicationsBioassay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Blockade of Receptor-ligand Interaction,Neutralization,Immunocytochemistry,CyTOF-ready
ReactivityHuman,Mouse,Rat
HostGoat
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
IsotypeIgG
Quantity100 ug (also 25 ug)
TargetNotch-1
NCBI Full Gene Namenotch receptor 1
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant rat Notch-1, Arg20-Glu488 (Ala208Thr, Asp334Glu), Accession # Q07008
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects rat Notch-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant rat Notch-2 and recombinant mouse Notch-3 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Transplantation of Human-Fetal-Spinal-Cord-Derived NPCs Primed with a Polyglutamate-Conjugated Rho/Rock Inhibitor in Acute Spinal Cord InjuryCellsOctober 20, 2022Giraldo E, Bonilla P, Mellado M, Garcia-Manau P, Rodo C, Alastrue A, Lopez E, Moratonas EC, Pellise F, Đorđević S, et al.(1:400; GTX16667, GeneTex), mouse anti-Nestin (1:400; MAB5326, Sigma Aldrich), mouse anti-Notch-1 (1:400; AF1057, R&D System, Minneapolis, Minnesota, USA), mouse anti-Olig2 (1:400; AB9610, Sigma-Aldrich), mouse anti-FOXJ1

(2) Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory ConditionsFrontiers in immunologyJanuary 1, 2022Filipović M, Flegar D, Šućur A, Šisl D, Kavazović I, Antica M, Kelava T, Kovačić N, Grčević D.seeding to prevent drying. For Notch neutralization, we used anti-Notch 1 neutralizing antibodies (AF1057, R&D Systems), targeting the negative regulatory region of the Notch 1 receptor, preventing cleavage

(3) Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury TreatmentInternational journal of molecular sciencesMay 31, 2021Bonilla P, Hernandez J, Giraldo E, González-Pérez MA, Alastrue-Agudo A, Elkhenany H, Vicent MJ, Navarro X, Edel M, Moreno-Manzano V.(1:400; MAB5326, Abcam), mouse antiNestin (1:400; MAB5326, Sigma Aldrich), mouse anti-Notch-1 (1:400; AF1057, R&D System, Minneapolis, MN, USA), mouse anti-O4 (1:200; MAB345, Sigma-Aldrich), and mouse antiFOXJ1

(4) Notch signaling pathway is a potential therapeutic target for extracranial vascular malformationsScientific reportsDecember 20, 2018Davis RB, Pahl K, Datto NC, Smith SV, Shawber C, Caron KM, Blatt J.polyclonal NOTCH4-ICD generated at Columbia P&S and goat polyclonal full-length NOTCH1 (1:100 R&D Systems AF1057) staining were previously described37. Image Acquisition Images for the assays were taken on an Olympus

(5) Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch SignalingCell stem cellOctober 4, 2018Verma M, Asakura Y, Murakonda BSR, Pengo T, Latroche C, Chazaud B, McLoon LK, Asakura A.

(6) Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent PatterningDevelopmental cellMarch 13, 2017Shaya O, Binshtok U, Hersch M, Rivkin D, Weinreb S, Amir-Zilberstein L, Khamaisi B, Oppenheim O, Desai RA, Goodyear RJ, et al.

(7) Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/Mena^INV-initiated invadopodium formationScientific reportsNovember 30, 2016Pignatelli J, Bravo-Cordero JJ, Roh-Johnson M, Gandhi SJ, Wang Y, Chen X, Eddy RJ, Xue A, Singer RH, Hodgson L, et al.

(8) Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterusVascular cellJanuary 1, 2015Shawber CJ, Lin L, Gnarra M, Sauer MV, Papaioannou VE, Kitajewski JK, Douglas NC.,R&D Systems,AF599,1:100 Hey2,Rabbit,Abcam,ab25404,1:200 LYVE1,Rabbit,Abcam,ab14917,1:1000 NG2,Rabbit,Millipore,AB5320,1:750 Notch1,Goat,R&D Systems,AF1057,1:200 Notch2,Rabbit,Abcam,Ab8926,1:500 Notch3,Rabbit,Abcam,Ab60087,1:50 Notch4 Rb2-2,Rabbit,Dr. Kitajewski’s

(9) OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cellsJournal of immunology (Baltimore, Md. : 1950)June 1, 2013Gopisetty A, Bhattacharya P, Haddad C, Bruno JC Jr, Vasu C, Miele L, Prabhakar BS.antibody was purchased from Biolegend. Blocking antibodies to OX40L (AF1236), Jagged1 (AF599), Notch1 (AF1057) and Notch3 (AF1308) and normal goat IgG control (AB-108-C) were purchased from R&D systems (Minneapolis,

(10) Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signalingStem cells and developmentFebruary 1, 2011Robinson AP, Foraker JE, Ylostalo J, Prockop DJ.stain neurons; rabbit anti-Jagged 1 (Abcam, cat#Ab7771; 1:200) and goat anti-Notch 1 (R&D Systems, cat# AF1057; 1:100) to stain Notch signaling proteins. After PBS washes, coverslips were incubated with flourescent

(11) Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture systemNeuronNovember 26, 2008Watkins TA, Emery B, Mulinyawe S, Barres BA.

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Notch-1 Antibody

Notch-1 Antibody

Notch-1 Antibody

Notch-1 Antibody

Notch-1 Antibody

Notch-1 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (11)

Reviews

Notch-1 Antibody from R&D Systems, a Bio-Techne Brand

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