Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor ab120487 from Abcam

Product Specs
ItemZ-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120487
Quantity1 mg, 5 mg
Purity0.9
TypeInhibitor, inhibitor
Molecule NameZ-VAD(OMe)-FMK

Sequence

VAD

Add to Compare List

Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Pyra-metho-carnil disrupts cancer cell proteostasis and induces apoptosis by binding to KDEL receptorsScientific ReportsMarch 26, 2026Kazumasa Yoshida, Kensuke Nishi, Takanori Kitaguchi, Taichi Matsumoto, Gen Maruta, Hisanori Maeoka, Shuhei Ishikura, Senji Shirasawa, Toshiyuki Tsunodafinal concentrations of 10, 30, and 60 μM as indicated. The caspase inhibitor z-VAD (OMe)-fmk (Abcam, ab120487) was used at a final concentration of 10 μM and the SERCA inhibitor thapsigargin (T9033; Sigma-Aldrich)

(2) Superoxide Activates Ferroptosis via the Haber‐Weiss Reaction and Enhances Age‐Related Macular DegenerationAging CellAugust 10, 2025Ying Huang, Zhenxing Zhou, Mengjia Huan, Qi Guo, Xiaoqian Zhang, Ruiqi Lu, Lushu Chen, Xiumiao Li, Jin Yao, Qin Jiang, et al.Abcam), 5 μM N‐acetylcysteine (NAC) adjusted to pH of 7.4 (ab284541, Abcam), 50 μM Z‐VAD (OMe)‐FMK (ab120487, Abcam), 50 μM chloroquine (CQ, ab142116, Abcam), and 20 μM tetrathiomolybdate (TTM, HY‐128530, MCE).

(3) Quantitative hypermorphic FAM111A alleles cause autosomal recessive Kenny-Caffey syndrome type 2 and osteocraniostenosisJCI InsightFebruary 11, 2025Dong Li, Niels Mailand, Emma U. Ewing, Saskia Hoffmann, Richard C. Caswell, Lewis Pang, Jacqueline Eason, Ying Dou, Kathleen E. Sullivan, Hakon Hakonarson, et al.14 days. Unless otherwise indicated, the following drug concentrations were used: Z-VAD-FMK (50 μM, ab120487, Abcam) and doxycycline (1 μg/mL, Sigma-Aldrich). Immunoblotting was performed as previously described

(4) Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating LckJournal of biomedical scienceMarch 27, 2024Chyuan IT, Liao HJ, Tan TH, Chuang HC, Chu YC, Pan MH, Wu CS, Chu CL, Sheu BC, Hsu PN.immunoprecipitation antibodies were used at a dilution of 1:200. The pan-caspase inhibitor Z-VAD-FMK (catalog no. ab120487) was purchased from Abcam. All the antibodies used for the immunoblotting and immunoprecipitation were

(5) Neuronal MD2 induces long-term mental impairments in septic mice by facilitating necroptosis and apoptosisFrontiers in pharmacologyJanuary 1, 2022Fan Z, Ma H, Li Y, Wu Y, Wang J, Xiong L, Fang Z, Zhang X.and donkey anti-mouse IgG H&L (Alexa Fluor® 488) (ab150105, Abcam). Inhibitors, including Z-VAD-FMK [ab120487, Abcam, 5 μg/μl, intracerebroventricular (icv) administration], necrostatin-1 (Selleck, 3 μg/μl, icv),

(6) FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human diseaseEMBO reportsOctober 5, 2020Hoffmann S, Pentakota S, Mund A, Haahr P, Coscia F, Gallo M, Mann M, Taylor NM, Mailand N.indicated, the following drug concentrations were used: nocodazole (10 μM, Sigma‐Aldrich), Z‐VAD‐FMK (50 μM, ab120487, Abcam), doxycycline (1 μg/ml, Sigma‐Aldrich), and AEBSF (5 mM, Sigma‐Aldrich). Immunochemical methods For immunoblotting

(7) Endothelial cell death subroutines at physiological and supraphysiological concentrations of calcium phosphate bionsNauchno-prakticheskii zhurnal «Patogenez»September 24, 2020В.Е. Маркова, Д.К. Шишкова, А.Г. Кутихинкаспазы-3 Z-D(OMe)E(OMe)VD(OMe)-FMK (Abcam, ab120488) в концентрации 100 мкмоль/л или пан-каспазный ингибитор Z-VAD(OMe)-FMK (Abcam, ab120487) также в концентрации 100 мкмоль/л. Далее в каждую лунку ка- ждой из трех указанных экспериментальных

(8) Butoxy Mansonone G Inhibits STAT3 and Akt Signaling Pathways in Non-Small Cell Lung Cancers: Combined Experimental and Theoretical InvestigationsCancers (Basel)March 28, 2019Panupong Mahalapbutr, Piyanuch Wonganan, Warinthorn Chavasiri, Thanyada Rungrotmongkolpurchased from Cell Signaling Technology (Santa Cruz, CA, USA). The pan-caspase inhibitor Z-VAD(OMe)-FMK (ab120487) was purchased from Abcam (Cambridge, UK). 4.1.2. Cell Lines and Culture Human NSCLC cell lines A549

(9) A novel probe to assess cytosolic entry of exogenous proteinsNature communicationsAugust 6, 2018Lu Q, Grotzke JE, Cresswell P.Enzo Life Sciences (Cat# BML-PI127-0100) or ApexBio Technology (Cat# A2606). z-VAD(OMe)-FMK was from Abcam (Cat# ab120487). Cytochalasin D was from Sigma-Aldrich (Cat# C8273). Dynasore was from Abcam (Cat# ab120192). Radicicol

(10) Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing FactorsCancer cellJuly 9, 2018Pavlyukov MS, Yu H, Bastola S, Minata M, Shender VO, Lee Y, Zhang S, Wang J, Komarova S, Wang J, et al.810150P Cisplatin,Sigma,Cat# 479306 Temozolomide,Sigma,Cat# T2577 Staurosporin,Sigma,Cat# S4400 zVAD(OMe)fmk,Abcam,Cat# ab120487 5-Aza-2′-deoxycytidine,Sigma,Cat# A3656 Pladienolide B,Santa Cruz Biotechnology,Cat# sc-391691 Isoginkgetin,EMD

(11) What is the best protocol to cryopreserve immature mouse testicular cell suspensions?Reproductive BioMedicine OnlineJuly 1, 2018Jaime Onofre, Katrien Faes, Prashant Kadam, Elena Vicini, Ans M.M. van Pelt, Ellen Goossenswhich was put in a −80°C freezer overnight. In the ﬁnal set of experiments, 60 µM of Z-VAD(OMe)FMK (ab120487; Abcam, Cambridge, UK) was included in the original cryoprotective medium to study the effect of an

(12) LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesisNatureMay 1, 2018Peltzer N, Darding M, Montinaro A, Draber P, Draberova H, Kupka S, Rieser E, Fisher A, Hutchinson C, Taraborrelli L, et al.A2220-5ML) for 16 h. For FADD immunoprecipitation, transformed MEFs were treated with 20 μM zVAD-fmk (Abcam, ab120487) in the presence or absence of 100 ng/mL 6xHis-TNF for 3 h. Cells were lysed as described above and

(13) ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell lineCell death & diseaseDecember 14, 2017Nishi K, Iwaihara Y, Tsunoda T, Doi K, Sakata T, Shirasawa S, Ishikura S.activity, cells were preincubated for 1 h with NAC (A7250, Sigma-Aldrich) and z-VAD(OMe)-fmk (z-VAD-fmk, ab120487, AbCam), respectively. The siRNAs against caspases were purchased from Invitrogen (Asheville, NC, USA).

(14) Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative ModelsScientific ReportsMay 23, 2016Linghui Qian, Cheng-Wu Zhang, Yanli Mao, Lin Li, Nengyue Gao, Kah-Leong Lim, Qing-Hua Xu, Shao Q. Yaotetrapeptide-AMC substrates were done where indicated. For inhibitor treatments, Z-VAD(OMe)-FMK (50 μM, ab120487, Abcam) or caspase-3/7 inhibitor I (200 μM for tissue lysate, Calbiochem #218826) was pre-incubated

(15) Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reactionCell death & diseaseJanuary 1, 0001"Henning Y, Blind US, Larafa S, Matschke J, Fandrey J."Aldrich, Taufkirchen, Germany), phenylmethylsulfonyl fluoride (10837091001, Sigma Aldrich), Z-VAD-FMK (ab120487, Abcam, Cambridge, UK), Nec-1s (ab221984, Abcam), GSK872 (ab254395, Abcam), Necrosulfonamide (NSA) (480073,

(16) Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathwayPLoS pathogensJanuary 1, 0001"Gain C, Malik S, Bhattacharjee S, Ghosh A, Robertson ES, Das BB, Saha A."background. Materials and methods Drugs MG132 (ab141003), bortezomib (ab142123) and Z-VAD(OMe)-FMK (ab120487) were obtained from Abcam (Cambridge, UK). Chloroquine diphosphate salt (C6628), Cyclohexamide (C7698),

Be the First to Write a Review!

Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor from Abcam

Description

Sequence

Abcam

Citations (16)

Reviews

Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor from Abcam

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map