Z-VAD(OH)-FMK, Irreversible general caspase inhibitor ab120382 from Abcam

Product Specs
ItemZ-VAD(OH)-FMK, Irreversible general caspase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120382
Quantity1 mg, 5 mg
Purity0.98
TypeInhibitor, inhibitor
Molecule NameZ-VAD(OH)-FMK, Irreversible general caspase inhibitor

Sequence

VAD

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndromeScience advancesSeptember 19, 2025Hildebrandt X, Veli Ö, Hyoubi A, Zinngrebe J, Abdallah AT, Rodefeld J, Hoffmann A, Gardeweg L, Kaya Ö, Wagner E, et al.viability assays 3T3-L1 preadipocytes cell death Cells were treated with 20 μM Z-VAD-fmk (Abcam, ab120382), 5 μM BV6 (Adooq Bioscience, Canada, A14231), 10 μM RIPK1 inhibitor Necrostatin 2 racemate (Nec-1s)

(2) Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing FerroptosisCancer Rep (Hoboken)April 24, 2025Takahiro Koyanagi, Yasushi Saga, Yoshifumi Takahashi, Kohei Tamura, Eri Suizu, Suzuyo Takahashi, Akiyo Taneichi, Yuji Takei, Hiroaki Mizukami, Hiroyuki Fujiwaracells/100 μL/well) seeded onto a 96‐well plate were exposed to the pan‐caspase inhibitor Z‐VAD‐FMK (ab120382; Abcam, Cambridge, UK), caspase‐1 specific inhibitor Z‐YVAD‐FMK (S8507; Selleck Biotech, Tokyo, Japan),

(3) Fatal COVID-19 pulmonary disease involves ferroptosisNature CommunicationsMay 20, 2024Baiyu Qiu, Fereshteh Zandkarimi, Anjali Saqi, Candace Castagna, Hui Tan, Miroslav Sekulic, Lisa Miorin, Hanina Hibshoosh, Shinya Toyokuni, Koji Uchida, et al.chemicals were purchased from qualified vendors: staurosporine, Selleck Chemicals S1421; Z-VAD-FMK, Abcam ab120382; LCL-161, ChemieTek CT-LCL161; TNFα, PeproTech 300-01 A; ferric ammonium citrate, Sigma-Aldrich F5879;

(4) Bcl-xL activity influences outcome of the mitotic arrestFrontiers in PharmacologySeptember 15, 2022M. Suleimenov, S. Bekbayev, M. Ten, N. Suleimenova, M. Tlegenova, A. Nurmagambetova, S. Kauanova, I. Vorobjevand barasertib (AZD1152-HQPA, Cat. #S1147) were purchased from Selleckchem Inc. Z-VAD(OH)-FMK (Cat. # ab120382), primary antibodies against Bcl-xL (Cat. # ab32370) and Bcl-2 (Cat. # ab182858), and horseradish peroxidase–conjugated

(5) Potent pro-apoptotic combination therapy is highly effective in a broad range of cancersCell death and differentiationMarch 1, 2022Montinaro A, Areso Zubiaur I, Saggau J, Kretz AL, Ferreira RMM, Hassan O, Kitzig E, Müller I, El-Bahrawy MA, von Karstedt S, et al.Dinaciclib (Selleck Chemicals Cat# S2768, 25 µM, 100 µM), NVP-2 (25 µM, 100 µM,), zVAD-fmk (Abcam Cat# ab120382, 20 µM). Antibodies against the following antigens were used: RNA-Pol II, pSer2 (Thermo Fisher Scientific

(6) miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2Molecular BrainDecember 1, 2019Xiao Xiao, Youjing Jiang, Weibo Liang, Yanyun Wang, Shuqiang Cao, He Yan, Linbo Gao, Lin Zhangwere purchased from Selleck Chemicals (Houston, TX, USA), while Necrosulfonamide (ab143839) and ZVAD-FMK (ab120382) were purchased from Abcam (Cambridge, Mass, USA). The antibodies used in this study were as follows:

(7) WX20120108, a novel IAP antagonist, induces tumor cell autophagy via activating ROS-FOXO pathwayActa Pharmacologica SinicaNovember 1, 2019Rui Ding, Xin Wang, Wei Chen, Zhi Li, Ai-li Wei, Qing-bin Wang, Ai-hua Nie, Li-li Wanghigh-performance liquid chromatography. GDC-0152 (Cat. no. S7010, Fig. 1) and wortmannin (S2758) were purchased from Selleck (TX, USA). Z-VAD-FMK (ab120382) was purchased from Abcam (MA, USA). Chloroquine (CQ, P36235) was purchased from Thermo Scientiﬁc (MA,

(8) Galactose:PEGamine coated gold nanoparticles adhere to filopodia and cause extrinsic apoptosis†Nanoscale AdvancesFebruary 12, 2019Konstantina Tzelepi, Cristina Espinosa Garcia, Phil Williams, Jon GoldingI (Merck, 218773) or 50 nM caspase 9 inhibitor II (Merck, 218776) or caspase 3/7 inhibitor (Abcam, ab120382) for 1 h prior to addition of 10 μg ml−1 AuNPs and incubation for 3 h. 10 μM Antimycin A (Abcam, ab141904)

(9) miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanomaCell death and differentiationAugust 1, 2018Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, O'Connell D, Zhang P, Li Y, Gao T, et al.were obtained from Selleck Chemicals (Houston, TX, USA). Necrosulfonamide (ab143839) and Z-VAD-FMK (ab120382) were obtained from Abcam. Compound 968 (352010), GPNA (G1135), and amino-oxyacetate (AOA; C13408) were

(10) Receptor-Interacting Protein 3/Caspase-8 May Regulate Inflammatory Response and Promote Tissue Regeneration in the Periodontal MicroenvironmentMedical science monitor : international medical journal of experimental and clinical researchJuly 29, 2018Yan B, Wei K, Hou L, Dai T, Gu Y, Qiu X, Chen J, Feng Y, Cheng H, Yu Z, et al.mixture was from CWBIO Company (China). RT Master Mix was from Takara (Japan). Inhibitor Z-VAD-fmk (ab120382) was from Abcam and GSK’872(2673-5) was bought from BIOVISION. The Annexin V-FITC/PI cell apoptosis

(11) Effect of Ephedra foeminea active compounds on cell viability and actin structures in cancer cell linesJournal of Medicinal Plants ResearchNovember 17, 2017Mendelovich Maayan et al.caspase-3 activity Z-VAD-FMK (N-benzyloxycarbonylVal-Ala-Asp(OMe)-fluoromethylketone. Abcam, Cat # ab120382, Cambridge, United Kingdom), a cell-permeable pan-caspase inhibitor that irreversibly binds to the catalytic

(12) DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cellsReproduction (Cambridge, England)August 1, 2017Tsui KH, Wang PH, Lin LT, Li CJ.Taiwan); Anti-caspase-9 (ab115161), anti-caspase-3 (ab90437), Necrostatin-1 (ab141053) and z-VAD-FMK (ab120382) were purchased from Abcam. Anti-β-actin (A5411) was purchased from Sigma. Statistical analysis Each

(13) Inhibition of autophagy blocks cathepsins–tBid–mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytesCell Death & DiseaseFebruary 1, 2017Xian-Yong Zhou et al.at 37 °C. 3-MA (08592, Sigma) at 0.1, 0.5 and 1 mM, Wort (W3144, Sigma) at 25, 50 and 100 nM, z-VAD (ab120382, Abcam, Cambridge, UK) at 25, 50 and 100 μM or Q-DEVD-OPh (ab142037, Abcam) at 25, 50 and 100 μM was

(14) Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosisScientific reportsApril 24, 2015Li CJ, Sun LY, Pang CY.necrostatin-1 (Nec-1, 0.1mM, ab141053; Abcam, MA, USA) or/and a pan-caspase inhibitor z-VAD-FMK (0.01 mM, ab120382; Abcam, MA, USA) prior to the final 0.5 mM H2O2 challenge. Cell proliferation assay Cell proliferation

(15) Implications of the O-GlcNAc modification in the regulation of nuclear apoptosis in T cellsBiochimica et Biophysica Acta (BBA) - General SubjectsJanuary 1, 2014Bruno Johnson, Marlyse Opimba, Jacques BernierON, Canada). sWGA-bound agarose beads were from Vector Laboratories Inc. (Burlington, ON, Canada). Z-VAD-FMK (ab120382) were from Abcam Inc. (Toronto, ON, Canada). SuperSignal West Femto chemiluminescent substrate (34096)

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Z-VAD(OH)-FMK, Irreversible general caspase inhibitor from Abcam

Description

Sequence

Abcam

Citations (15)

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Z-VAD(OH)-FMK, Irreversible general caspase inhibitor from Abcam

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