SB 203580, p38 MAPK inhibitor ab120162 from Abcam

Product Specs
ItemSB 203580, p38 MAPK inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120162
Quantity1 mg, 10 mg, 50 mg, 500 µg
Purity0.99
TypeInhibitor, inhibitor
Molecule Name4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

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(1) A human-specific non-coding RNA for EFHC1, an epilepsy-associated gene, regulates neural stem cell proliferation for cortical developmentStem Cell ReportsSeptember 8, 2026Sota Nishida, Boyang An, Hayato Uchida, Shota Zenno, Takumi Nojima, Arisa Makimura, Fumihiro Morishita, Mizuki Honda, Takuya ImamuraSelect (Gibco, 12563029). For the rescue experiments, the p38 MAPK inhibitor SB203580 (10 μM; Abcam, ab120162) or endoplasmic reticulum (ER) stress inhibitor 4-Phenylbutanoic acid (10 μM; Angene, AG0023DD) was

(2) Distinct roles of HMOX1 on tumor epithelium and macrophage for regulation of immune microenvironment in ovarian cancerInternational journal of surgery (London, England)October 1, 2025Liu Y, Jiang LJ, Liu HF, Chen L, Guo L, Ge J, Zhang XY, Li J, Gong W.Recombinant human TGF beta 1 protein (ab50036), IMD-0354 (ab144823), LY294002 (ab120243), U0126 (ab120241), SB203580 (ab120162), PDTC (ab141406), Mouse SPP1 ELISA Kit (ab100734), Mouse TGF beta 1 ELISA Kit (ab119557), Mouse TNF alpha ELISA Kit

(3) Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid OverloadDrug Des Devel TherApril 1, 2025Xi-Xi Hou, Shuang Wang, Xiao-Xia Ma, Ying Wen, Zhi-Jun Li, Xu-Yun Liu, Xing Zhang, Yang Zhang, Xiang-Yang QinμM PA for 24 h. HAECs were pretreated for 30 min with or without the p38 inhibitor SB203580 (10 μM, ab120162, Abcam Inc, Cambs, UK), or Erk inhibitor U0126 (10 μM, 109511–58-2, MedChemExpress, SNJS, USA), or NF-κB

(4) Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid OverloadDrug Des Devel TherApril 1, 2025Xi-Xi Hou, Shuang Wang, Xiao-Xia Ma, Ying Wen, Zhi-Jun Li, Xu-Yun Liu, Xing Zhang, Yang Zhang, Xiang-Yang QinμM PA for 24 h. HAECs were pretreated for 30 min with or without the p38 inhibitor SB203580 (10 μM, ab120162, Abcam Inc, Cambs, UK), or Erk inhibitor U0126 (10 μM, 109511–58-2, MedChemExpress, SNJS, USA), or NF-κB

(5) PARP15 Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy–Associated Systemic Capillary Leak Syndrome)Arteriosclerosis, Thrombosis, and Vascular BiologyDecember 1, 2024Eunice C. Chan, Ararat J. Ablooglu, Chandra C. Ghosh, Abhishek Desai, Niccole Schaible, Xiuying Chen, Ming Zhao, M. Renee Olano, Sundar Ganesan, Justin B. Lack, et al.inhibitor, Cat# ab120065), PF573228 (FAK inhibitor, Cat# ab273523), and SB203580 (p38 inhibitor, Cat# ab120162) were purchased from Abcam. A detailed list of antibodies and other reagents used is provided in the

(6) Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates SenescenceAntioxidants (Basel)November 28, 2024Myeong Uk Kuk, Duyeol Kim, Yun Haeng Lee, Jee Hee Yoon, Ji Ho Park, Yoo Jin Lee, Byeong Hyeon So, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, et al.(ROS) GDC0068 (S2808; Selleckchem, Houston, TX, USA), SB590885 (SML0501; Sigma, St. Louis, MO, USA), SB203580 (ab120162; Abcam, Cambridge, UK), and SC79 (SML0749; Sigma) were diluted to a final concentration of 5 mM using

(7) PARP15 is a susceptibility locus for Clarkson disease (monoclonal gammopathy associated systemic capillary leak syndrome)Arterioscler Thromb Vasc BiolOctober 31, 2024Eunice C. Chan, Ararat J. Ablooglu, Chandra C. Ghosh, Abhishek Desai, Niccole Schaible, Xiuying Chen, Ming Zhao, M. Renee Olano, Sundar Ganesan, Justin B. Lack, et al.inhibitor, Cat# ab120065), PF573228 (FAK inhibitor, Cat# ab273523), and SB203580 (p38 inhibitor, Cat# ab120162) were purchased from Abcam. A detailed list of antibodies and other reagents used is provided in the

(8) PSKH1 affects proliferation and invasion of osteosarcoma cells via the p38/MAPK signaling pathwayOncology LettersFebruary 28, 2023Xingfei Zhu, Chao Jiang, Zhiyuang Wang, Xiaozhong Zhu, Feng Yuan, Yi Yangwith 5% CO2. In rescue experiments, cells were pretreated with p38/MAPK inhibitor SB203580 (cat. no. ab120162; Abcam) or DMSO for 1 h at 37°C. Construction of lentivirus and cell transfection For the knockdown

(9) Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB PathwayAntioxidants (Basel)January 11, 2023Xuyun Liu, Jing Gao, Yizhen Yan, Eleftheria A. Georgiou, Jing Lou, Mengya Feng, Xing Zhang, Feng Gao, Jiankang Liu, Ioannis K. Kostakis, et al.and cellular experiments was synthesized by Ioannis K. Kostakis. The P38 inhibitor SB203580 (catalog, ab120162) and NF-κB inhibitor QNZ (catalog, ab141588) were obtained from Abcam Inc. (Boston, MA, USA). The ERK

(10) Estrogen Suppresses Cytokines Release in cc4821 Neisseria meningitidis Infection via TLR4 and ERβ-p38-MAPK PathwayFrontiers in MicrobiologyMarch 29, 2022Pengbo Guo, Juan Xu, Hao Liang, Li Xu, Wanying Gao, Ziman Chen, Yuan Gao, Maojun Zhang, Guangfu Yu, Zhujun Shaopathway inhibitor treatment, HBMECs and MECs were pretreated with p38 inhibitor SB203580 (20 μM) (#ab120162, Abcam) before E2 treatment for 24 h. Western Blotting for Signaling Pathway Screening Human brain

(11) Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer CellsFrontiers in oncologyJanuary 1, 2022Alsamri H, Alneyadi A, Muhammad K, Ayoub MA, Eid A, Iratni R.627601) and 3-methyladenine (cat.189490) were obtained from Millipore (Hayward, CA, USA). SB 203580 (cat. Ab120162), SB 202190 (cat. Ab1206388158), and chloroquine (cat. Ab142116) were obtained from Abcam (Cambridge,

(12) MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagyMolecular medicine reportsDecember 1, 2021Lan CN, Cai WJ, Shi J, Yi ZJ.SP600125 (a JNK inhibitor; Abcam; cat. no. ab120065) or SB203580 (a p38 inhibitor; Abcam; cat. no. ab120162), respectively, once a day for 3 days. All animals were fed in cages at the Animal Center of Second

(13) Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3Journal of neuroinflammationJuly 5, 2021Li HN, Yang QQ, Wang WT, Tian X, Feng F, Zhang ST, Xia YT, Wang JX, Zou YW, Wang JY, et al.Abcam, #ab120950), ERK (PD98059, 5.0 μg/μl; Abcam, #ab120234), p38 MAPK (SB203580, 20 μg/μl; Abcam, #ab120162), and NF-κB (PDTC, 200 ng/μl; Sigma, #P8765) were first prepared with DMSO and then diluted with 0.9%

(14) TGF‑β1‑induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathwaysInternational Journal of Molecular MedicineNovember 3, 2020Jing Zhang, Na Jiang, Jian Ping, Lieming XuJS1 cells were pre-treated with 10 µM PD98059 (cat. no. ab120234; Abcam), 10 µM SB203580 (cat. no. ab120162; Abcam) or 10 µM SP600125 (cat. no. ab120065; Abcam) for 1 h, followed by treatment with or without

(15) MicroRNA‑375 prevents TGF‑β‑dependent transdifferentiation of lung fibroblasts via the MAP2K6/P38 pathwayMolecular medicine reportsSeptember 1, 2020Zhang X, Chen Q, Song H, Jiang W, Xie S, Huang J, Kang G.Recombinant human TGF‑ β protein (active; cat. no. ab50036) and SB203580 (P38 in hibitor; cat. no. ab120162) were obtained from Abcam. The mimic (cat. no. miR10000728‑1‑5) and inhibitor (cat. no. miR20000728‑1‑5)

(16) Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling PathwayDrug Design, Development and TherapyDecember 31, 2019Kai Kang, Yue Wangblock MAPK signaling pathway, the SKOV3 cell lines were incubated with p38 inhibitor SB203580 (20 μM, ab120162, Abcam, Cambridge, MA, USA) or JNK inhibitor SP600125 (10 μM, ab120065, Abcam) according to the manufacturer’s

(17) p38 MAPK‑MK2 pathway regulates the heat‑stress‑induced accumulation of reactive oxygen species that mediates apoptotic cell death in glial cellsOncology LettersNovember 8, 2017Hongbo Li, Yanan Liu, Zhengtao Gu, Li Li, Yunsong Liu, Lin Wang, Lei Suab141496; Abcam, Cambridge, MA, USA), SP600125 (10 µM; cat. no. ab120065; Abcam), SB203580 (5 µM; cat. no. ab120162; Abcam), PD98059 (10 µM; cat. no. ab120234; Abcam), SB202474 (10 µM; cat. no. IMA1013; Jingke Science

(18) Ubiquitin-specific protease 4 (USP4) suppresses myoblast differentiation by down regulating MyoD activity in a catalytic-independent mannerCellular signallingJuly 1, 2017Yun SI, Kim KK.

(19) SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 PhosphorylationPLOS ONEFebruary 2, 2016Gopinathan Pillai Sreekanth, Aporn Chuncharunee, Aunchalee Sirimontaporn, Jutatip Panaampon, Sansanee Noisakran, Pa-thai Yenchitsomanus, Thawornchai Limjindaporn

(20) Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y₁₂ and P2Y₁₃ receptors in neuropathic pain ratsJournal of neuroinflammationJanuary 1, 0001"Niu J, Huang D, Zhou R, Yue M, Xu T, Yang J, He L, Tian H, Liu X, Zeng J."no. ab120934, Abcam), SB203580 (p38 mitogen-activated protein kinase (p38MAPK) inhibitor, cat. no. ab120162, Abcam), and PDTC (nuclear factor-kappaB (NF-kappaB) inhibitor, cat. no. ab141406, Abcam) were dissolved

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SB 203580, p38 MAPK inhibitor from Abcam

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SB 203580, p38 MAPK inhibitor from Abcam

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