Fig 2: CDHR5 promotes invasion and migration capacity of PDAC cells. A, Knock‐down of CDHR5 expression by siRNA in AsPC‐1. B, Viability of AsPC‐1 cells treated with CDHR5‐siRNA was measured by CCK‐8 assay. C, Invasion capability of AsPC‐1 cells treated with CDHR5‐siRNA was measured by invasion assay. D, Migration capability of AsPC‐1 cells treated with CDHR5‐siRNA was measured by migration assay. E, Invasion and migration capability of AsPC‐1 cells treated with CDHR5‐siRNA. ***P < .001

Fig 3: Expression of CDHR5 in PDAC cell lines. Relative expression of CDHR5 in mRNA level (left) and protein level (right)

Fig 4: IHC staining of CDHR5 in PDAC and NAT tissues. A, The CDHR5 staining intensity was recorded as score 0‐3 in both PDAC and NAT samples. B, CDHR5 expression in PDAC and matched NAT was compared in each patient. C, Representative IHC staining pictures of CDHR5 expression in occurrence and progression of PDAC. Scale bar = 100 μm. ***P < .001

Fig 5: Expression of CDHR5 isoforms in PDAC cell lines. A, CDHR5‐L relative expression in PDAC cell lines. B, CDHR5‐M relative expression in PDAC cell lines